Genetics Lectures

Genetics Part 1

NEET / AIIMS 2018 - Genetics Lecture - 2 (NCERT - 12th) Terminology

This lecture explains the terminology of genetics:
1. Gene
2. Genotype & Phenotype
3. Allele / Allelomorph
4. Homozygous & Heterozygous
5. Hemizygous
6. mutation
7. Dominant & Recessive
8. Reciprocal cross
9. Back cross & Test cross
10. True breeding lines
11. Punnett square
12. Monohybrid cross & Dihybrid cross

4. Molecular Genetics I

(April 5, 2010) Robert Sapolsky makes interdisciplinary connections between behavioral biology and molecular genetic influences. He relates protein synthesis and point mutations to microevolutionary change, and discusses conflicting theories of gradualism and punctuated equilibrium and the influence of epigenetics on development theories.

Stanford University

Stanford Department of Biology

Stanford University Channel on YouTube

Genetics part 1 introduction to advanced genetics

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Mendelian inheritance was initially derived from the work of Gregor Johann Mendel published in 1865 and 1866 which was re-discovered in 1900. It was initially very controversial. When Mendel's theories were integrated with the Chromosome Theory of Inheritance by Thomas Hunt Morgan in 1915, they became the core of classical genetics.
The laws of inheritance were derived by Gregor Mendel, a nineteenth-century Austrian monk conducting hybridization experiments in garden peas (Pisum sativum).[1] Between 1856 and 1863, he cultivated and tested some 5,000 pea plants. From these experiments, he deduced two generalizations which later became known as Mendel's Principles of Heredity or Mendelian inheritance. He described these principles in a two-part paper, Experiments on Plant Hybridization, that he read to the Natural History Society of Brno on February 8 and March 8, 1865, and which was published in 1866.[2]

Mendel's conclusions were largely ignored. Although they were not completely unknown to biologists of the time, they were not seen as generally applicable, even by Mendel himself, who thought they only applied to certain categories of species or traits. A major block to understanding their significance was the importance attached by 19th-century biologists to the apparent blending of inherited traits in the overall appearance of the progeny, now known to be due to multigene interactions, in contrast to the organ-specific binary characters studied by Mendel.[1] In 1900, however, his work was re-discovered by three European scientists, Hugo de Vries, Carl Correns, and Erich von Tschermak. The exact nature of the re-discovery has been somewhat debated: De Vries published first on the subject, mentioning Mendel in a footnote, while Correns pointed out Mendel's priority after having read De Vries's paper and realizing that he himself did not have priority. De Vries may not have acknowledged truthfully how much of his knowledge of the laws came from his own work, or came only after reading Mendel's paper. Later scholars have accused Von Tschermak of not truly understanding the results at all.[1]

Regardless, the re-discovery made Mendelism an important but controversial theory. Its most vigorous promoter in Europe was William Bateson, who coined the terms genetics and allele to describe many of its tenets. The model of heredity was highly contested by other biologists because it implied that heredity was discontinuous, in opposition to the apparently continuous variation observable for many traits. Many biologists also dismissed the theory because they were not sure it would apply to all species. However, later work by biologists and statisticians such as R. A. Fisher showed that if multiple Mendelian factors were involved in the expression of an individual trait, they could produce the diverse results observed. Thomas Hunt Morgan and his assistants later integrated the theoretical model of Mendel with the chromosome theory of inheritance, in which the chromosomes of cells were thought to hold the actual hereditary material, and created what is now known as classical genetics, which was extremely successful and cemented Mendel's place in history.

Mendel's findings allowed other scientists to predict the expression of traits on the basis of mathematical probabilities. A large contribution to Mendel's success can be traced to his decision to start his crosses only with plants he demonstrated were true-breeding. He also only measured absolute (binary) characteristics, such as color, shape, and position of the offspring, rather than quantitative characteristics. He expressed his results numerically and subjected them to statistical analysis. His method of data analysis and his large sample size gave credibility to his data. He also had the foresight to follow several successive generations (f2, f3) of pea plants and record their variations. Finally, he performed test crosses (back-crossing descendants of the initial hybridization to the initial true-breeding lines) to reveal the presence and proportion of recessive characters. Source of the article published in description is Wikipedia. I am sharing their material. Copyright by original content developers of Wikipedia.

NEET I Biology I Principle of Inheritance & Variation I M. Asad Qureshi Sir From ETOOSINDIA.COM

Principle of inheritance and variation video Lecture of Biology for NEET by MAQ Sir. MAQ Sir is known for his unique, focused and simplified NEET teaching to bring to students an easy and analytical methodology towards NEET.
This course is designed and developed by the experienced faculty of KOTA and In this lecture MAQ Sir is giving the detailed view of Principle and variation.
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GENETICS Introduction by Professor Fink

In this Video Lecture Professor Fink provides a simple description of genetic concepts first using the trait of Eye Color & a Punnett Square, and then describing the transmission of most Genetic Diseases using a Punnett Square. Reference is made to dominant genes, recessive genes, the Genotype, homozygous, heterozygous, the Phenotype, alleles, Genotypic Ratio, Phenotypic Ratio, Carrier and the use of a Pedigree Chart.
Professor Fink then describes the characteristics of Benign versus Malignant Tumors (Cancer) and the 4 Major Theories related to the Causes of Cancer. Reference is made to oncogenes, metastasis, transformation, Genetic Factors (BRCA & p-53), Mutagenic (Carcinogenic) Factors, Non-Lytic (Lysogenic viruses; Human Papilloma Virus; HPV), and the role of the Immune System.

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Genetics as Revolution - 2015 JBS Haldane Lecture with Alison Woollard

The ideas of genetics are revolutionary. Today, technology is galvanising disruptive change in our understanding and ability to intervene with nature itself. What can we change, and should we?
Professor Alison Woollard presents the 2015 Genetics Society JBS Haldane Lecture.

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It is an everyday observation that the offspring of elephants are elephants and the offspring of humans are humans. Our biology is, quite literally, written in our DNA, and the copying and transmission of this genetic information is the most extraordinary process on earth.

The ideas of genetics are revolutionary, from Mendel’s perfect 19th century description of the mechanism of heredity, through the molecular revolutions of the 20th century to the present day. Today, new technologies are galvanising disruptive change, not only in our understanding of biology, but in our ability to intervene in the very nature of life itself. What can we change? How? Why? And indeed, should we meddle at all?

“The bravest”, said Thucydides, “Are surely those who have the clearest vision of what is before them, glory and danger alike, and yet notwithstanding, go out to meet it”. See if you agree.

Find out more about the JBS Haldane Lectures on the Genetics Society website:

Alison Woollard is an Associate Professor in the Department of Biochemistry at the University of Oxford where she is also a Fellow of Hertford College, Oxford. She gave the 2013 CHRISTMAS LECTURES, 'Life Fantastic'

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Virology Lectures 2018 #3: Genomes and Genetics

Viruses are unusual because their genome can be DNA or RNA, and they can occur in seven different configurations. In this lecture we review each type of viral genome and trace the pathway to mRNA. We discuss the largest and smallest genomes, what is and is not encoded in the genome, and how to manipulate the viral genome to facilitate their study and their use as vectors.

Linkage and Recombination, Genetic maps | MIT 7.01SC Fundamentals of Biology

Linkage and Recombination, Genetic maps
Instructor: Eric Lander
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20. Human Genetics, SNPs, and Genome Wide Associate Studies

MIT 7.91J Foundations of Computational and Systems Biology, Spring 2014
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Instructor: David Gifford

This lecture by Prof. David Gifford is on human genetics. He covers how scientists discover variation in the human genome. He discusses how to prioritize variants based on their importance. And then covers how to prove causation, not just correlation.

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NEET Biology Principle of Inheritance and Variation video lectures by Shivani Bhargava (SB) Mam

Principle of Inheritance and Variation video Lecture of Biology for NEET by SB Mam.SB Mam is known for her unique, focused and simplified NEET teaching to bring to students an easy and analytical methodology towards NEET.
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Mendelian Genetics

029 - Mendelian Genetics

Paul Andersen explains simple Mendelian genetics. He begins with a brief introduction of Gregor Mendel and his laws of segregation and independent assortment. He then presents a number of simple genetics problems along with their answers. He also explains how advances in genetic knowledge may lead to ethical and privacy concerns.

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All of the images are licensed under creative commons and public domain licensing:
File:Alice's Restaurant.jpg. Wikipedia, the Free Encyclopedia, December 18, 2012.
File:Autosomal DOminant Pedigree Chart.svg, n.d.
File:Basal Ganglia and Related Structures.svg. Wikipedia, the Free Encyclopedia. Accessed November 29, 2013.
File:Bendable Thumb.jpg. Wikipedia, the Free Encyclopedia. Accessed December 1, 2013.
File:Ingrid Moller.jpg, n.d.
File:Meiosis Overview.svg. Wikipedia, the Free Encyclopedia. Accessed December 1, 2013.
File:Neuron with mHtt Inclusion.jpg. Wikipedia, the Free Encyclopedia. Accessed November 29, 2013.
File:Peas in Pods - Studio.jpg. Wikipedia, the Free Encyclopedia. Accessed December 1, 2013.
File:Snow Pea Flowers.jpg. Wikipedia, the Free Encyclopedia. Accessed December 1, 2013.
File:Woody Guthrie NYWTS.jpg. Wikipedia, the Free Encyclopedia. Accessed December 1, 2013.
Madprime. Genetics Diagram: Punnett Square Describing One of Mendel's Crosses, between Parents That Are Heterozygous for the Purple/white Color Alleles., May 5, 2007. Own work.

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Genetics, epigenetics and disease

Royal Society GlaxoSmithKline Prize Lecture given by Professor Adrian Bird CBE FMedSci FRS on Tuesday 22 January 2013.

Adrian Bird CBE FMedSci FRS is the Buchanan Chair of Genetics at the University of Edinburgh.

The human genome sequence has been available for more than a decade, but its significance is still not fully understood. While most human genes have been identified, there is much to learn about the DNA signals that control them. This lecture described an unusually short DNA sequence, just two base pairs long, CG, which occurs in several chemically different forms. Defects in signalling by CG are implicated in disease. For example, the autism spectrum disorder Rett syndrome is caused by loss of a protein that reads methylated CG and affects the activity of genes.

The Royal Society GlaxoSmithKline Prize Lecture is awarded for original contributions to medical and veterinary sciences published within ten years from the date of the award.

Genetic Engineering and Society, Lecture 1a, Honors Collegium 70A, UCLA

Course Description:
Honors Collegium 70A: Genetic Engineering in Medicine, Agriculture, & Law is a class that examines the historical and scientific study of genetic engineering in medicine, agriculture, and law, including examination of social, ethical, and legal issues raised by new technology.

About the Professor:
Bob Goldberg is a plant molecular biologist who specializes in the area of plant gene expression. The goal of his research has been to understand how plant cells differentiate and how genes are activated selectively in specialized cell types during plant development. He has received UCLA Distinguished Teaching Awards from the Department of Biology and the Department of Molecular, Cell, and Developmental Biology, and was awarded the all-campus Luckmann Distinguished Teaching Award from the Academic Senate.

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5. Molecular Genetics II

(April 7, 2010) Robert Sapolsky continues his series on molecular genetics in which he discusses domains of mutation and various components of natural selection on a molecular level. He also further assesses gradualism and punctuated equilibrium models of evolution, integrating these theories into an interrelated model of development.

Stanford University

Stanford Department of Biology

Stanford University Channel on YouTube

Lec 6 | MIT 7.012 Introduction to Biology, Fall 2004

Genetics 1 (Prof. Eric Lander)

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PATHOLOGY LECTURES , GENETICS , Part 4 , Autosomal Recessive Disorder

1. Introduction to Human Behavioral Biology

(March 29, 2010) Stanford professor Robert Sapolsky gave the opening lecture of the course entitled Human Behavioral Biology and explains the basic premise of the course and how he aims to avoid categorical thinking.

Stanford University

Stanford Department of Biology

Stanford University Channel on YouTube


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