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Does Vitamin D help with Immunity?

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Does Vitamin D help with Immunity?

Hopefully YT does not take this video down, as its all based on medical studies. If they keep doing this, I will have to upload my videos to a different website.

The Vitamin D supplement that I take:


So what does not having enough vitamin D have to do with COVID? And IF insufficient vitamin D levels CAUSE more severe disease, why is that? Well, I have to first clarify that it's not proven that insufficient levels of vitamin D lead to worse outcomes. But while it hasn’t been proven, it also certainly hasn’t been disproven. And there is more and more compelling evidence suggesting that lower levels lead to worse outcomes. And there’s no question that vitamin D plays an important role in our immune system. More and more studies are coming out that are sorting out its exact role in this capacity. But the link between poor vitamin D status and risk of certain infections remains cloudy. Back in 2017, there was a meta-analysis study that consisted of 25 different randomized trials with about 11,000 patients in total, evaluating the incidence of acute respiratory infection.

Vitamin D supplementation reduced the percentage of patients experiencing an acute respiratory tract infection. The incidence of URTI in the vitamin D group was 40.3%, compared to 42.2% in the placebo group. In a subgroup analysis, vitamin D supplementation was most effective in patients with vitamin D levels less than 10 ng/mL and in those treated with daily or weekly smaller doses, as opposed to a huge single dose. The takeaway from this meta-analysis study is that, being vitamin d deficient probably makes people more prone to getting upper respiratory infections, and that they should take supplemental vitamin D. But people who have low levels should be taking supplemental vitamin D regardless. Vitamin D has major effects on nearly all cells of our immune system, including dendritic cells, macrophages, and T and B lymphocytes. All of these immune cells have a receptor that binds to vitamin D, called vitamin D receptor, or VDR.

Here are some questions we still need answers to:
1) what level of vitamin D is adequate to protect against, or minimize the impact, of COVID?
2) What level of vitamin D is considered too high
3) should more and more people get their vitamin D levels checked, especially during this pandemic, when less and less people are physically going to the doctor?
4) should people just supplement themselves? If so, how much?

These are all tough questions to answer, especially because we won’t have the results of RCT for vitamin D anytime soon. Given the fact that low dose vitamin D is pretty darn safe, it seems quite reasonable for people to take a low dose supplement, especially if they think they might not be getting enough from sunlight or their diet. Of course, ideally, you want to have a discussion with your doctor if possible.

A common question is, How much Vitamin D should I take a day?
Personally, I take 1,000 IU per day. I know that I’m not going to run anywhere near toxic levels of vitamin D with that dose, while at the same time, I know that I won’t be vitamin D deficient.

Dr. Mike Hansen, MD
Internal Medicine | Pulmonary Disease | Critical Care Medicine
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#coronavirus #covid19 #covid_19
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Vitamin D, Immune System & SARS-CoV-2 (COVID-19) | Mechanism of Vit D Immune Regulation & Overview

Vitamin D, Immune System & SARS-CoV-2 (COVID-19) | Mechanism of Vit D Immune Regulation, Overview of Evidence

In this lesson, I discuss the vitamin D its immune system regulation, specifically with regards to how vitamin D can help protect against respiratory tract infections like SARS-CoV-2 (COVID-19).

1) Brief Introduction to Vitamin D and SARS-CoV-2

2) Vitamin D deficiency and increased risk of infections

3) Vitamin D supplementation and protection against acute respiratory tract infections

4) Vitamin D and Immune System Regulation (including cytokines like IL-6)

5) Vitamin D and SARS-CoV-2 (COVID-19), comorbidities and associations

3) Summary of some Remdesivir data in in-vitro and in-vivo (mice and rhesus monkeys) studies used in treatment of other coronaviruses like SARS-CoV and MERS-CoV

****EXCLAIMER: The content (ex. images) used in this lesson are used in accordance with Fair Use laws and is intended for educational purposes only.****

*DISCLAIMER* Although there has been a meta-analysis showing reduced risk of acute respiratory tract infections with daily/weekly recommended doses of Vitamin D, WE DON’T have enough evidence to say that Vitamin D is protective against SARS-CoV-2 (COVID-19) – WE ONLY HAVE ASSOCIATIONS/CORRELATIONS at this point.

***This video is merely here to PRESENT INFORMATION from the studies quoted in this video - if people have an issue with the data, I would suggest they read over these studies and contact the experimenters/authors****

I hope you find this lesson helpful! If you do, please give this video a thumbs up and consider subscribing to the channel – all of your support is greatly appreciated!
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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

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Vitamin D and Immunity, Lots of Evidence

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Public Health England
Vitamin D recommendations


Vit D and COVID


Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths.

Prevalence and correlates of vitamin D deficiency in US adults





About 42% of the US population is vitamin D deficient. However, this rate rises to 82% in black people and 70% in Hispanics

Vit D deficiency in Ireland

Vitamin D is essential for bone and muscle health


Arizona University





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Could Vitamin D Help Fight COVID-19?

My opinion is that you keep the correct levels of vitamin D in your body. Now a days, due to staying indoors, it is possible that you will develop the deficiency of vitamin D. Get this checked by your doctor and use the correct dose to stay healthy.

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Here are my notes:
Daily 10 microgram or 400 IU/Day

Lippincott’s Biochemistry Review 4th Edition. Page 388
Daily 5 mg of cholecalciferol or 200 IU of Vitamin D.

However, 800 IU/Day is shown to reduce the incidence of osteoporotic fractures.
800 IU/Day recommended by the Institute of Medicine to maintain bone health.

Frank deficiency is when the levels of 25-hydroxycholecalciferol (25OHD) is less than 20 ng/mL (50 mmol/L)


No consensus that the oral vitamin D supplements are helpful

Ergocalciferol from plants is called Vitamin D2
Cholecalciferol from the animal tissue is called Vitamin D3

7 deidro-cholesterol to (UV light) to cholecalciferol (D3) to 25 hydroxylase in liver to 25 OH D to -hydroxycholecalciferol 1-hydroxylase in kidney to 1,25 DiOH D3




Vitamin D Receptors are abbreviated to VDR in the notes. These are cytosolic receptors.


Deficiency of vitamin D makes people more susceptible to respiratory tract infections.
Vitamin D supplement can reduce these infections by 12%
Keep in mind, this is for those who are deficient in this vitamin. If you are not deficient, then it will not make a difference. Because, you are already good.
Evidence is not sufficient to say that vitamin D helps prevent respiratory infections.

2018 Study

People with autoimmune diseases commonly have hypovitaminosis D

What are cathelicidins?


What are beta defensins?



2011 Study


Activation of TLR and PAMPs on macrophages increases the production of 1, alpha hydroxylase and the VDR. This in turn causes more production of cathelicidine and beta defensins 4.

Vitamin D also affects monocytes to reduce production of IL1, IL6, IL8, IL12, and TNF. Regulating the immune response.

Vitamin D acts on the dendritic cells to inhibit/reduce their differentiation and maturation. It reduces their MHCII expression, co-stimulatory molecules like CD40, CD80, CD86, decreased production of IL-12 etc.

2013 Study

Vitamin D improves immune system by helping produce cathelicidine and by helping modulate inflammatory cascade. Especially for the respiratory infections.
It also helps produce NFk-B (nuclear factor kappa light chain for activated B cells.)

(
Notes about the NFkB

Helps with cytokine production and cell survival.
NFk-B factor becomes active when T and B cell receptors become active. Its activation causes the gene expressions that allow T cell development, maturation, and proliferation.
T and B cells have Vitamin D receptors that help them produce NFk-B
)

Continuing the notes from the study:
In pulmonary infections. Lung epithelial cells are able to convert inactive vitamin D to its active form. This active Vitamin D then helps produce cathelicidine. Which helps kill the pathogens.

Vitamin D seems to favor TH2 and TH17 cell activation which is anti-inflammatory profile.
Vitamin D seems to reduce the activation of TH1 cells which are pro inflammatory by their IFN-gamma action.
A deficiency of vitamin D may dysregulate the inflammatory response of the body.

Vitamin B also increases the IkBa. This leads to inhibition of NFkB. This helps reduce the production of IL6 and IL8 by inhibiting the production of NFkB.
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Vitamin D and coronavirus: Sunlight and nutrition could help boost immunity | ABC7

Some studies have found that patients who were hit hardest by COVID-19 had low levels of vitamin D in their bodies. A SoCal doctor is explaining why this might be the case and what we can do to boost our vitamin D levels. Details:

Should you take Vitamin C and Vitamin D for Coronavirus | COVID

Should you take Vitamin C and Vitamin D for Coronavirus | COVID-19

⏩ Timestamps, click to skip ahead!
00:00 - Introduction
00:38 - Does Colder Temperatures make you more prone to getting COVID?
02:52 - Why COVID are more likely to cause infections in winter?
03:20 - Vitamin D and COVID
07:20 - Vitamin C and COVID
09:47 - Zinc and COVID

This is the Vitamin D that I take:


Coronavirus | COVID-19 YouTube Video Playlist:


Does colder temperature make you more prone to getting a cold Or COVID-19?
Most health experts agree that when it’s cold, people spend more time indoors and in close contact with other people, and this likely increases the spread of germs.
Also, experts believe that our immune system may be more active when our body is warmer, as in during the summer months.

Back in 2007, there was this study…


In this one particular study looking at the spread of the influenza virus, they put guinea pigs together in a chamber and carried out different environmental experiments on them. They found that low relative humidities of 20%–35% were most favorable for infection, while the transmission was completely blocked at high humidity of 80%.
They also found that when guinea pigs were kept at 5 °C, transmission occurred with greater frequency than at 20 °C, while at 30 °C, no transmission was detected.
The authors concluded that low relative humidities produced by indoor heating and cold
temperatures favored the spread of the influenza virus.

I also want to add, that cold weather, by itself, can cause a runny nose without necessarily
having a cold, and this allows for the virus so be carried in those secretions, which probably facilitates transmission.
40% of common colds are caused by rhinoviruses. The second most common cause of cold is the coronavirus, the normal one, not this novel coronavirus, aka SARS-CoV-2.
Its been shown that the rhinovirus reproduces more quickly at cooler temperatures means you might catch a cold more quickly if you’re chilly.

And this probably applies to the coronavirus as well.

It's likely that with the combination of all of these 5 factors, meaning, cooler temp, lower humidity, people staying indoors more often in winter months, cold weather causing runny noses and our immune system is more active when it's warmer, these combinations of factors likely explain why colds, flu,, and COVID-19 are more likely to cause infections in the winter months.
But there is likely a 6th factor as well. And that is vitamin D. Our bodies don’t normally make vitamin D unless we get sunlight. In the winter months, for most of us in this world, we don’t get enough sunlight to make enough vitamin D. Unless you live in a warm climate, then maybe you are the exception. So if you aren’t getting enough sunlight in the winter months, that means you have to get enough vitamin D in your diet. And if you don’t do that, you will have low vitamin D levels. Vitamin D helps regulate or Calcium levels and is important for bone and muscle health. It also plays a role in regulating our immune system, but its exact role is not known.

Why is this important when it comes to the common cold, flu, and perhaps with this novel the coronavirus that’s causing COVID-19? Well, vitamin D doesn’t affect these viruses themselves. Instead, it affects our immune systems.

So what is my recommendation for taking Vitamin D?
The best thing to do is check with your doctor to see if you might have low vitamin D, and if it is low, you’ll def need to get more vitamin D, especially during the winter months.

Vitamin C is a water-soluble vitamin that is vital to the function of white blood cells that help to fight infections, and overall immune system health. Vitamin C is also important for iron absorption, and being deficient in iron can make you more vulnerable to infections in general.
The normal, recommended daily intake of vitamin C for adults from the diet and/or supplements is 75 to 120 mg. You can get about 80 to 90 mg from a cup of orange juice or sliced orange, or even more from kiwi fruit, or a cup of sweet peppers.

Zinc has become one of the most popular suggestions for reducing symptoms of coronavirus.
Some studies showed that zinc reduces the duration of a cold by half, while others showed no effect. Another study found that the type of zinc taken determined the result—zinc gluconate lozenges that provided 13.3 milligrams (mg) of zinc lessened the duration of colds, but zinc acetate lozenges that provided 5 mg or 11.5 mg of zinc did not.

Note: Please watch the whole video to get the proper details, for the character limitation of the youtube description, I couldn't provide the whole details, so I suggest you, watch the whole video.

Dr. Mike Hansen, MD
Internal Medicine | Pulmonary Disease | Critical Care Medicine

Symposium 14, Vitamin D and immunity: Chantel Mathieu

Chantel Mathieu presents her symposium on Vitamin D and immunity at ECE 2016.

The Effects of Vitamin D on the Immune System

This is The Vitamin D + K2 that I Recommend:

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A number of cross-sectional studies have confirmed the protective role of vitamin D. In cross-sectional studies (CSS), researchers stratify subjects according to their levels of vitamin D and then they assess differences between these groups. For example, in CSS of 800 finish recruits, they found that recruits with vitamin D deficiency spend significantly more days out of duty because of upper respiratory infections than recruits with higher vitamin D levels (above 40nmol). In another CSS

These data are backed by a meta-analysis published in The British Journal of Medicine. Here, they analysed 25 studies with 11321 total participants and vitamin D supplementation was shown to reduce the risk of acute respiratory tract infection.

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review

Our immune system is powerful but needs to be kept in check. There is a direct correlation between the severity of influenza and levels of released cytokines. In avian influenza, high levels of cytokines are reflective of fatal outcomes. This phenomenon is called “cytokine storm”. The pathological storm is probably caused by immune cells being infected, breaking regulatory cascades and dysregulating inflammatory response which can irreversibly damage lung tissue.

These cytokines are released among others by cells called macrophages. As reported in a study published in Molecular and Cellular Endocrinology, Vitamin D was found to modulate macrophages’ response and prevents them from releasing too many cytokines.

Furthermore, a study published in Cellular Immunology, also reported that Vitamin D deficiency is dysregulating maturation of macrophages in bone marrow, the primary site of immune cell production. These unmatured macrophages cannot produce anti-microbial compounds like hydrogen peroxide (H202) or acid phosphate which serves as a hydrolysing (degrading) enzyme in lysosomes.

H202 and acid phosphate are not the only antimicrobial agents. Antimicrobial peptides (AMP) are released by monocytes and neutrophils. These peptides are endogenous antibiotics and some of them like defensins directly destroy invading microorganism. As reported in the Journal of Immunology, vitamin D can stimulate the expression of these peptides. Indeed, AMPs were reported to be crucial in the fight against influenza.

A study published in Science, reported that upon triggering of toll-like receptors by pathogens, the expression of genes coding for vitamin D receptor and vitamin D1 is stimulated. The higher density of vitamin D receptor and a higher concentration of vitamin D then enhanced the production of antimicrobial peptides as described in the previous paragraph.

Cells fighting intracellular pathogen need autophagy to “clean up the mess” connected with the infection. Many proteins might be misfolded due to the dysregulated intracellular pH and other cytosolic components might be damaged by the entry of the pathogen. Autophagy is the mechanism through which dysfunctional cellular components are degraded. In a study published in Cell Host & Microbe, it was reported that vitamin D can induce autophagy in monocytes and macrophages.

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Vitamin D for COVID-19 - What Vitamin D Does to Your Immune System

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ABOUT THIS VIDEO: Does Vitamin D work against COVID-19? There was a lot of information that came out on this topic. In this video, we'll talk about vitamin D and its effects on the immune system, vitamin D supplements vs. sunlight, and the safe dosage if you would take supplements.

Chapters
0:00 Introduction (vitamin D benefits)
1:52 Vitamin D's effects against respiratory tract infection
5:23 Vitamin D lowers inflammation & suppress cytokine storm
7:45 Vitamin D deficiency & COVID-19 mortality
8:40 Vitamin D sources (sunlight, diet, supplements)
11:00 Vitamin D safe dosage
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Here's the link to a Medscape video/article where Dr. JoAnn Manson, professor of medicine at Harvard Medical School and Brigham and Women's Hospital, explained the connections between vitamin D deficiency, the immune system, and COVID-19:
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Vitamin D for: Immunity and Benefits

Vitamin D for Immunity [Subtitles]

In today's video we explore the benefits of Vitamin D for the immune system and how this can help to protect you against infections. Vitamin D plays a key role in modulating and controlling the immune system by keeping the t-cells and other immune cells in line. Over 1 billion people are deficient in this due to not getting enough sunshine or poor absorption. Today we explain how to get more of this into your body, how to maximise absorption and how it can help to supercharge immunity.

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Vitamin D dose

Vitamin D dose
International units or micrograms
1,000 micrograms (mcg) in a milligram (mg)
1,000 milligrams (mg) in a gram (g)
1,000 grams in a kilogram (Kg)
1 kg is 2.2 pounds
IU mcg
400 10mcg
800 20mcg
1,000 25mcg
2,000 50mcg
4,000 100mcg


US

42% of people have a vitamin D deficiency

82.1% of black people

69.2% of Hispanic people.
Higher blood levels = over 33 ng/ml or 82.4 nmol/l
Lower blood levels less than 12 ng/ml or 30 nmol/l
50% lower risk of colorectal cancer
Consuming 1,000 IU (25 mcg) daily would help 50% of people reach a vitamin D blood level of 33 ng/ml (82.4 nmol/l)
Consuming 2,000 IU (50 mcg) daily would help nearly everyone reach a blood level of 33 ng/ml (82.4 nmol/l)
Taking 1,000 IU (25 mcg) of vitamin D daily reduced heart disease risk by 10%
Consuming 1,000–4,000 IU (25–100 mcg) of vitamin D daily should be ideal for most people to reach healthy vitamin D blood levels.
However, don’t consume more than 4,000 IU of vitamin D without your doctor's permission. It exceeds the safe upper limits of intake and is not linked to more health benefits













(pdf link)

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COVID19 and Vit D immunity | Vit D and COVID19 | Coronavirus and Vit D | Basic Science Series

COVID19 and Vitamin D | Immunity and vitamin D | Role of Vitamin D in viral infection | COVID19 and Vit D immunity | Vit D and COVID19 | Coronavirus and Vit D

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The innate immune system consists of physical barriers such as skin mucous membranes, and various cell types like, monocytes and macrophages, cytokines, and the complement. In contrast to the adaptive immune response, the innate response is not specific to any foreign invader and as a result, works quickly to destroy pathogens entered in our body. The key question is that how vitamin D is linked with infection. The simple answer is that the deficiency of vitamin D has been linked to increased risk or severity of viral infections, including HIV. Low levels of vitamin D appear to be a risk factor for other serious infections like tuberculosis. In addition to that, research support that the vitamin D Supplementation may slightly reduce the severity and risk of respiratory tract infections. More specifically, the research studies during COVID-19 pandemic raised concerns that, as vitamin D deficiency is a risk factor in respiratory infection. In addition to that it is also suggested that incidence, severity and outcomes of COVID-19 infection could be related with variances in vitamin D levels. There are several published reports of case series showing direct associations between vitamin D deficiency, COVID-19 infection and severity. The possible benefits by the vitamin D supplementation has been encouraged by various health professionals. howerver there was insufficient evidence at that time to support taking vitamin D supplements specifically to prevent or treat COVID‑19, health professionals recommended all people should continue to follow advice on daily vitamin D supplementation during the COVID‑19 pandemic. All these facts and findings motivates us to know the functions of vitamin D in detail. Before understanding Vitamin D, let’s first understand the vitamin. A vitamin is an organic molecule that is an essential micronutrient. An organism needs a vitamin in small quantities for the proper functioning of its metabolism. Vitamin D is a fat-soluble vitamin and it helps in intestinal absorption of calcium, magnesium, and phosphate, and have multiple other biological effects on our body. In humans, the most important Vitamin D compounds are vitamin D3 (also known as cholecalciferol) and vitamin D2 (ergocalciferol).The major natural source for humans is the synthesis of vit D in the lower layers of skin through a chemical reaction that is dependent on sun exposure. Cholecalciferol and ergocalciferol can be acquired from the diet and from supplements. Only a few foods, such as the flesh of fatty fish, naturally contain significant amounts of vitamin D. In the U.S. and other countries, cow's milk, and plant-derived milk substitutes are fortified with vitamin D. Vitamin D from skin synthesis or from the diet is biologically inactive. Means it has no function in this form. It needs activation. It is activated by two enzyme hydroxylation steps, the first in the liver and the second in the kidneys. As vitamin D can be synthesized in adequate amounts by most mammals if exposed to sufficient sunlight, it is important to know that it is not essential, so technically not a vitamin. Instead, it can be considered a hormone, with activation of the vitamin D pro-hormone resulting in the active form, calcitriol, which then produces effects via a nuclear receptor in multiple locations. Cholecalciferol is converted in the liver to 25-hydroxy cholecalciferol); and ergocalciferol is converted to 25-hydroxy ergocalciferol. These two vitamin D metabolites (called 25-hydroxyvitamin D can be measured in serum to determine a person's vitamin D status. Based on this information the vitamin deficiency can be detected in any patient. 25-hydroxy cholecalciferol is further hydroxylated by the kidneys to form calcitriol (also known as 1,25-dihydroxycholecalciferol), the biologically active form of vitamin D.


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How Does Vitamin D Help Us Fight COVID?

Dr. David Metzler from the University of Chicago joins to share about the findings of his recent study, which found that patients who were vitamin D deficient were about 77% more likely to test positive for COVID than patients who weren’t. There are many ways to get vitamin D, including the sun, vitamin D fortified foods, and supplements.

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Vitamin D: Boost Your Immune System

Dr. Jawad talks about how vitamin D will give your immune system a boost.

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Vitamin D3's role in immune function | Rhonda Patrick

Vitamin D is a steroid hormone that is a major regulator of immune function and plays a particularly important role in preventing respiratory tract infections. Vitamin D activates the innate immune system, which elicits an early antiviral response. The vitamin binds to receptors on neutrophils, macrophages, and natural killer cells and stimulates them to produce microbial peptides that have antiviral activity. Vitamin D also increases T-regulatory cells, which play a major role in keeping the immune system in check, particularly when it comes to autoimmune diseases. Vitamin D inhibits the production of proinflammatory cytokines, which can play a role in a cytokine storm. In this clip, Dr. Rhonda Patrick details the critical role that vitamin D plays in the immune response.

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Needed: Zinc, Magnesium, Vitamin D & Vitamin C- Immune System Health

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We NEED Zinc, Magnesium, Vitamin D & Vitamin C for Our Immune System Health- Thomas DeLauer
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Immune cells need vitamin C, but without vitamin D T cells remain dormant. However, taking vitamin D will deplete magnesium stores. Zinc also has a positive influence on the immune system, as does copper.Iron does have a role in immune system function, but you cannot excrete excess, which can cause damage to organs, and it competes with magnesium for oxygen. So, in theory, taking too much iron could reduce magnesium, which could then render vitamin D useless, which would ultimately mean taking vitamin C would be pointless in regards to T cells as they wouldn't be able to activate and utilize vitamin C.

Vitamin C

Immune cells have active vitamin C transporter molecules embedded in their membranes that actively pump the vitamin into the cells when more vitamin C is required

Vitamin C produces beneficial effects on virtually all of the immune system’s cells

Study - Nutrients

In 2014, a study of vitamin C published in the journal Nutrients found that vitamin C supplementation can reduce the incidence of the common cold in otherwise healthy people with chronic stress or obesity

During the study, 85% of placebo recipients experienced a cold compared with just 47% of supplemented subjects



Vitamin D

When a T cell is exposed to a foreign pathogen, it extends a signaling device (vitamin D receptor) with which it searches for vitamin D

This means that the T cell must have vitamin D or activation of the cell will cease - if the T cells cannot find enough vitamin D in the blood, they won't activate

Vitamin C Needed to Convert Vitamin D into its Active Form

A study published in the Journal of Nutrition revealed that Vitamin C plays a critical role in Vitamin D metabolism

It was found that while Vitamin C deficiency “potentiated effects of Vitamin D deprivation and impaired a restorative action of Vitamin D”

Vitamin C has been shown to specifically to influence the activity of 25(OH)D3-1-hydroxylase, the enzyme responsible for the transformation of 25(OH)D3 to 1,25(OH)2D3 (active form of D3)




Magnesium

A review published in The Journal of the American Osteopathic Association found Vitamin D can't be metabolized without sufficient magnesium levels

Magnesium is involved in hundreds of biological reactions, including the enzymes that play a role in vitamin D metabolism - vitamin D can't be converted into its active form, calcitriol, without sufficient amounts of magnesium





Zinc

When a pathogen is recognized, NF-κB is activated and enters the nucleus, a gene is expressed that produces a zinc transporter called ZIP8

After cell entry, zinc is then directed to and binds to a different protein in the NF-κB pathway - when this happens, it halts any further activity in that process
In other words, zinc helps prevent excess inflammation

It’s essentially a feedback loop, stopping the process getting out of hand





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VITAMIN D RICH FOOD TO BOOST YOUR IMMUNE SYSTEM - Corona virus(COVID 19)

Today, I want to introduce you the importance of Vitamin D.

As I have already introduced, Japanese people love mushrooms of all kind.

I've been told that eat mushroom everyday if you don't want to catch a cold since I was a child.

This study shows how Japanese Moms are right:


A Review of Mushrooms as a Potential Source of Dietary Vitamin D

Place Mushrooms in Sunlight to Get Your Vitamin D

※It's very common way to treat mushrooms in Japan.

As you already know, we live long, and the mortality rate of COVID 19 is relatively lower in our country.

I think our immune system is stronger than the other county based on the traditional diet.

I hope the video is helpful!

Stay safe!

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TOP 10 ZINC RICH FOOD TO BOOST YOUR IMMUNE SYSTEM -You should take now and forever! (EP182)


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Vitamin D Update

Vitamin D and Covid-19

Press release from the French National Academy of Medicine 22 May 2020



Vitamin D is a prohormone

Synthesized in the dermis under the effect of ultraviolet light

Transported to the liver and kidneys, where it is transformed into an active hormone

Responsible for intestinal absorption of calcium and bone health.

Modulates the functioning of the immune system by stimulating macrophages and dendritic cells

Role in regulating and suppressing the cytokine inflammatory response

Acute respiratory distress syndrome

A significant correlation between low serum vitamin D levels and mortality from Covid- 19

This phenomenon follows a North-South gradient

Exceptions are Nordic countries, vitamin D supplementation

Not a preventive or a therapeutic

By mitigating the inflammatory storm and its consequences, considered as an adjunct to any form of therapy.

Simple and inexpensive measure

Confirms its recommendation to ensure vitamin D supplementation in the French population

Recommends the rapid serum vitamin D (i.e. 25 OHD) testing in people over 60 years of age with Covid-19

Loading dose of 50,000 to 100,000 IU in case of deficiency, which could help limit respiratory complications;

Recommends vitamin D supplementation of 800 to 1000 IU/day in people under 60, as soon as the diagnosis of Covid-19 is confirmed.


Vitamin D: A Low-Hanging Fruit in COVID-19? (Medscape)



Observational data from various countries suggest inverse links;

Severity of COVID-19 responses
Mortality

No randomized controlled trial

Having adequate vitamin D is important, especially for those at the highest risk of COVID-19

No role
Simply a marker
A causal factor

Spain and northern Italy, high rates of vitamin D deficiency

Spain and Italy not formally fortify foods or recommend supplementation

Norway, Finland, and Sweden had higher vitamin D levels

European countries, P = .046, 95.4% confidence, (4.6% chance this result arose by chance)

Correlation is not causality

Optimizing vitamin D status to recommendations by national and international public health agencies will certainly have, potential benefits for COVID-19 (Irish Medical Journal),

Immune Modulation


Data from China, France, Germany, Italy, Iran, South Korea, Spain, Switzerland, United Kingdom, United States

Risk of severe COVID-19

Vitamin D deficiency was 17.3%

Normal Vitamin D level was 14.6%
(a reduction of 15.6%).

Ethnic Minorities Disproportionately Affected

British Association of Physicians of Indian Origin (BAPIO) to get their vitamin D levels tested.

LARGE, SINGLE-DOSE, ORAL VITAMIN D SUPPLEMENTATION IN ADULT POPULATIONS: A SYSTEMATIC REVIEW


They suggest a booster dose of 100,000 IU as a one-off

Single vitamin D3 doses ≥300,000 IU are most effective at improving vitamin D status…for up to 3 months

Daily doses of 1000 IU seem reasonable

Testing and Governmental Recommendations During COVID-19

US National Institute of Health


400 IU to 800 IU per day, will result in blood levels that are sufficient to maintain bone health and normal calcium metabolism in healthy people

Public Health England (PHE)


There is not sufficient evidence to support recommending Vitamin D for reducing the risk of COVID-19 (PHE)

Using VITAMIN D to Boost Your Immune System

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Dr. Sanda Moldovan explains how to use Vitamin D to boost your immune system! Make sure to subscribe and smash that notification bell to stay up to date with our new series on strengthening your immune system!

ABOUT

Dr. Sanda Moldovan is an award-winning periodontist and nutritionist as seen on CBS' renowned TV show The Doctors. With a firm belief in health from the inside out, Dr. Moldovan identifies health issues that originate in the mouth to empower patients towards a healthier life. She is a Diplomate of the American Academy of Periodontology and a member of Laser Dentistry and American College of Nutrition. Smile to a healthy future and stay connected with Dr. Moldovan!

8 Signs Your Body Is Begging for Vitamin D

What are the signs of vitamin D deficiency? Vitamin D greatly influences the systems of our body from ensuring calcium supply to our bones to strengthening our immune system. We normally get this vitamin from foods, supplements, and the sun’s rays, but when something goes wrong and we face vitamin D deficiency, our body systems may break.


For example, sweating that seems a little excessive or not brought on by anything particularly obvious, however, can be a sign that you’re lacking vitamin D. So what other signs show a deficiency, how serious is the problem, and what can you do to get more of it? Here at Bright Side, we’ve studied the most common symptoms of low vitamin D levels and we want to tell you what we’ve found.

TIMESTAMPS:
You sweat excessively 1:01
Your bones often ache 1:35
You have muscle pain 2:11
You get sick all the time 2:47
You can’t seem to stay energized 3:26
When you get cuts or bruises, they take forever to heal 4:03
You notice more hair falling out of your head than usual 4:52
You can’t shake the feeling of sadness 5:25
What can you do to get more of vitamin D? 6:26

#vitamind #vitamindeficiency #lackofvitamins

Preview photo credit:

FORT MEADE, Md. Sweat drips down the face of a U.S. Army Reserve Soldier from the 200th Military Police Command during a Spin class as part of a Performance Triad program organized by the command and hosted on Fort Meade, Maryland, May 9, 2017. The three-week fitness program took place from May 5-25 to help Soldiers who had either failed the Army Physical Fitness Test or had been on the Army Body Fat Composition program. The camp focused on the triad of overall health: physical fitness, nutrition and sleep, by providing education and personalized coaching to Soldiers in all three of those phases of life and more: By Master Sgt. Michel Sauret/U.S. Army Reserve,
Animation is created by Bright Side.

Music by Epidemic Sound

SUMMARY:
- Without vitamin D, your bones can’t absorb the necessary amount of calcium to create healthy bone tissue, causing a weakening of the bones known as osteomalacia.
- In addition to aching bones and muscles, a lack of vitamin D can cause chronic pain throughout the entire body. This debilitating condition is known as fibromyalgia, and it makes life a living nightmare for those who suffer from it!
- Suffering from your 4th or 5th virus this year? It may be because a lack of vitamin D is causing your immune system to work poorly.
- It’s 4 pm and you feel like you have two bricks as eyelids and barely have the strength to get up from your desk. Sound familiar? There could be quite a few reasons for this feeling. But it can also be due to a lack of vitamin D.
- Does it seem like your small wounds and injuries take longer to heal than everyone else’s? But this kind of slow healing can also be because of a lack of (say it with me) vitamin D!
- The average person loses anywhere from 50 to 100 hairs from their head every day. But if you suffer from a lack of vitamin D, you can lose way more than that, at least enough to notice that something’s definitely not right.
- According to Psychology Today, vitamin D is the only vitamin that is also a hormone. In studies on the relationship between vitamin D and depression, scientists discovered traces of the vitamin on cells found in the regions where depression resides.
- Vitamin D can be attained by spending time outside. According to The Arthritis Foundation, spending 10-15 minutes in the sun every other day or so can help replenish your vitamin D levels. Even sitting by an open window can help give you more vitamin D!

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