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Fasted State


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Fed State of Metabolism Vs Fasted State Metabolism MCAT (EVERYTHING YOU NEED TO KNOW BIOCHEMISTRY)

Video that goes into more details on the Fed State of Metabolism

Video that goes into more details on the Fasted State of Metabolism

Below is a video link that goes over every single major metabolic pathway you need to know for the MCAT!!



Dr. Jason Fung explains why weightloss cannot result from exercise alone and the benefits of training in a fasted state.

Dr. Jason Fung Audio Book:

The Obesity Code Cookbook by Dr. Jason Fung:

#jasonfung #fasting #intermittentfasting

Fasting Fuel:

The Complete Guide to Fasting: Heal Your Body Through Intermittent, Alternate-Day, and Extended Fasting

The Obesity Code: Unlocking the Secrets of Weight Loss

The Diabetes Code: Prevent and Reverse Type 2 Diabetes Naturally

The Longevity Solution: Rediscovering Centuries-Old Secrets to a Healthy, Long Life

The Obesity Code Cookbook: Recipes to Help You Manage Insulin, Lose Weight, and Improve Your Health

Innotech Nutrition Intermittent Fasting Drink Mix

Obesity code, the beginners guide to intermittent fasting 3 books collection set

Dr. Jason Fung is a Canadian nephrologist. He’s a world-leading expert on intermittent fasting and low carb, especially for treating people with type 2 diabetes. He has written three best-selling health books and he co-founded the Intensive Dietary Management program.
Dr. Fung has his own website at

Fasting benefits are immense, in terms of physical and spiritual health.

Dr. Fung works with Team Diet Doctor to make it simple for people to understand and implement intermittent fasting, to improve their health.
Dr. Jason Fung’s Website:

Intermittent Fasting by Dr. Jason Fung

Intermittent Fasting and Breakfast Misconceptions

Keto Diet is Harmful?/Should you do Keto?

Why Should you switch to a Plant-Based Diet?

Secret Weight Loss Food/ Weight Loss Motivation

2 Steps to Control your Weight

Quit Sugar Addiction in 4 Easy Steps

Visit Blog:

Jason Fung on Obesity Epidemic

Jason Fung Fasting [Complete Guide to Fasting]
Dr. Jason Fung's Tips For Fasting
Dr. Jason Fung Guide to Fasting [ 2019]
Intermittent Fasting the Most Powerful Healing Tool [Dr. Jason Fung]
Jason Fung on Muscle Loss with Fasting
Keys to Successful Fasting Dr. Jason Fung [How to Fast]
Dr. Jason Fung on Bariatric surgery or Fasting?
Dr. Jason Fung on Getting Patients to Fast
Intermittent Fasting & Insulin Resistance (Dr. Jason Fung)
Dr. Jason Fung on Intermittent Fasting [Treating Type 2 Diabetes]

FTC: Some links mentioned above are affiliates, which means I earn a small commission if you buy a product from the specific link. Video is not sponsored.

Intermittent Fasting - How it Works? Animation

Effect of fasting on fat burn, insulin sensitivity and brain's health. Methods and tips for safe and effective fasting. This video is available for instant download licensing here :

©Alila Medical Media. All rights reserved.
Voice by: Ashley Fleming
All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
Intermittent fasting refers to eating plans that alternate between fasting and eating periods. The goal is to systematically starve the body long enough to trigger fat burning. While research is still underway and the method may not be suitable for everyone, there is evidence that, when done correctly, intermittent fasting can help lose weight, lower blood pressure and cholesterol, prevent or control diabetes, and improve brain’s health.
During a meal, carbohydrates in food are broken down into glucose. Glucose absorbs through the intestinal wall into the bloodstream and is transported to various organs, where it serves as the major energy source. Excess glucose is stored for later use in the liver and adipose tissue, in the form of glycogen and fats. In between meals, when the body is in the fasted state, the liver converts glycogen back to glucose to keep supplying the body with energy. Typically, an inactive person takes about 10 to 12 hours to use up the glycogen stores, although someone who exercises may do so in much less time. Once the reserve of glycogen in the liver is depleted, the body taps into energy stores in adipose tissues. This is when fats are broken down into free fatty acids which are then converted into additional metabolic fuel in the liver. Thus, if the fasted state lasts long enough, the body burns fat for energy and loses that extra fat. Losing the extra fat is translated into a range of associated health benefits.
Insulin is the hormone required for driving glucose into cells. Insulin level is regulated to match the amount of glucose in the blood, that is, high after a meal and low between meals. Because insulin is secreted after each meal, eating throughout the day keeps insulin levels high most of the time. Constant high insulin levels may de-sensitize body tissues, causing insulin insensitivity - the hallmark of prediabetes and diabetes type 2. Fasting helps keep insulin levels low, reducing diabetes risks.
Fasting also has beneficial effect on the brain. It challenges the brain the same way physical or cognitive exercise does. It promotes production of neurotrophic factors, which support the growth and survival of neurons.
Fasting, however, is not for everyone.
Fasting can also be unsafe if overdone, or if not done correctly.
There are several approaches to intermittent fasting, but the easiest to achieve is perhaps the one that simply extends the usual nighttime fast. A daily cycle of 16-hour fast followed by a 8-hour eating window is usually sustainable.
For intermittent fasting to be safe and effective, it must be combined with balanced meals that provide good nutrition. It is important to stay hydrated, and know your physical limits while fasting. The fast must be broken slowly. Overeating after fast, especially of unhealthy foods, must be avoided.

Metabolic Changes During Fasting and Starvation

In this video I have explained the metabolic changes that occur during fasting and starvation. i have specially emphasized on the catabolic changes that occur in relation to glycogen breakdown, lipolysis, gluconeogenesis and ketone body synthesis.

My other videos on the related topics are as below:

Integration of metabolic pathways - fed state metabolism

Integration of metabolic pathways - Fasting state and Starvation

Precursors of gluconeogenesis and regulation

Gluconeogenesis precursors and important enzymes

Glycolysis and gluconeogenesis regulation

Propionyl CoA to glucose

Gluconeogenesis question and explanation

Glycolysis and gluconeogenesis regulation

Glucose-alanine cycle

Transamination reaction

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Metabolism in Fasting and Starvation. #neetpg#aiims#mednerd#usmle

A. The fasting state:
The blood-glucose level begins to drop several hours after a meal, leading to a decrease in insulin secretion and a rise in glucagon secretion.The main target organ of glucagon is the liver.
During fasting the blood-glucose level is kept at or above 80 mg/dl by three major factors:
(1) the mobilization of glycogen and the release of glucose by the liver,
(2) the release of fatty acids by adipose tissue, and 
(3) the shift in the fuel used from glucose to fatty acids by muscle and the liver.

B. Starvation
Under starvation conditions, the blood-glucose level must be maintained above 2.2 mM (40 mg/dl).
 1) The first priority of metabolism in starvation is to provide sufficient glucose to the brain and other tissues (such as red blood cells) that are absolutely dependent on this fuel. 
After 3 days of starvation, about a third of the energy needs of the brain are met by ketone bodies. After several weeks of starvation, ketone bodies become the major fuel of the brain .
2) The second priority of metabolism in starvation is to preserve protein, which is accomplished by shifting the fuel being used from glucose to fatty acids and ketone bodies

How Intermittent Fasting Affects Your Body and Brain | The Human Body

Stars like Beyonce and Hugh Jackman have spoken out about following intermittent fasting plans to get in shape. How does intermittent fasting work? Here's what actually happens to your body and brain when you fast. Following is a transcript of the video.

How long has it been since you last ate? People who fast intermittently often eat within an 8-hour block, leaving 16 hours of fasting in between. During that 16-hour stretch, their bodies undergo an important change that sets them apart from non-fasters.

Here's how it works.

When you eat, you store some of that energy in the liver as glycogen. But after 10-12 hours of not eating, your glycogen reserves will be extremely low. As a result, you may feel more irritable than normal, a term scientists call hangry.

The upside is — with little glycogen left — fat cells in your body release fats into your bloodstream. The fat cells head straight to your liver, where they're converted to energy for your body and brain. So, you are literally burning fat to survive.

Blood samples show that people who had fasted for 12-24 hours experienced a 60% increase in energy from fat, with the biggest change occurring after 18 hours. This is the benefit to intermittent fasting because it puts you in a state called ketosis. And it's why researchers think intermittent fasting could be the key to a longer, healthier life.

The process of burning fat releases chemicals called ketones. In the brain, ketones trigger the release of an important molecule called BDNF. BDNF helps build and strengthen neurons and neural connections in areas of the brain responsible for learning and memory. Which could explain why a boost in ketone production has been shown to improve memory in people with early signs of dementia in as soon as 6 weeks. Increasing ketones in the body is also a common treatment for patients with severe epilepsy.

You don't necessarily have to fast to boost your ketone levels. Introducing more fatty foods into your diet and cutting back on carbs can have a similar effect. A group of people who tried this method for 3 months not only lost weight and body fat, but also saw a decrease in blood pressure and a hormone (IGF-1) that is related to aging and disease.

But scientists have discovered that fasting increases ketone levels more. Ketogenic diets can increase ketones 4-fold whereas fasting has been shown to increase ketones by up to 20-fold. As a result, fasting — compared to a ketogenic diet — may have a stronger, more beneficial effect on overall health.

Yet many Americans who eat three meals a day with snacks in between never reach ketosis, and therefore aren't producing enough ketones to promote good health.

Fasting and ketosis have been a key to our survival from the beginning. They helped our ancient ancestors survive through bouts of starvation.

And today, they're becoming recognized as a way to help keep future generations mentally and physically disease-free.


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How Intermittent Fasting Affects Your Body and Brain | The Human Body

Dr. Smily Pruthi Discusses the Topic - Fasting State (Hinglish)

Watch Biochemistry Teacher, Dr. Smily Pruthi discuss the topic - Fasting State (Hinglish). For more such videos by India's Best Biochemistry faculty, Dr. Smily Pruthi, download the Biochemistry by Dr. Smily Pruthi app.

#PrepLadder #DrSmilyPruthi #Biochemistry

Fasted Training vs Eating Before Workouts: Study Compares the Difference

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Fasted Training vs Eating Before Workouts: Study Compares the Difference - Thomas DeLauer

This is the official fasted training versus non-fasted training video. What I mean by that is we're going to look at some of the science between what happens when you train in a completely fasted state, whether it's overnight or after an intermittent fast, or if you're training after eating some food.

It's a common battle that's occurring on the internet. It's a common battle that people talk about all the time. Which is better? You get a little bit more power when you're training with a little bit more energy in your system, but you might get a better response if you're training in a fasted state. So let's look at the science, and there's one particular study that I want to reference that's going to break it all down and give us some clear cut answers.

But the first thing that I want to talk about before we go into any detail on anything is I want you to stop worrying about if you're going to lose muscle or not. Here's the thing, if you work out for long enough, if you work out for long periods of time, yeah, you're going to burn up some muscle, but if you're training in a fasted state, the last thing I want you to worry about is losing muscle. Whether you're a man or woman, it doesn't matter. You're not going to lose as much muscle as you think, if any. The fact is you have way too many hormones that are skyrocketing when you're in a fasted state that far supersede the effects of catabolizing muscle.

You have high amounts of human growth hormone that stop the breakdown of muscle. Okay? But the other thing is once you've been fasted for a longer period of time, your liver starts to produce something known as BHB, Beta-Hydroxybutyrate, which is a ketone body. That ketone body stops what is called leucine breakdown or leucine oxidation. Leucine is an amino acid, and that amino acid is at the forefront of catabolism, muscle breakdown. It's very simple. If we have leucine in the equation, you're not breaking down muscle. If leucine is oxidizing, you're breaking down muscle.

In the case of fasting, when you have ketones present from a fast, it doesn't mean you have to be in ketosis, it just means you've been fasted, you have enough of this overall ketone production to make it so that you're not going to burn up that muscle, and you're not going to go into that leucine oxidation.

So now that that's out of the way, let's truly talk about the difference between training fasted and training fed, and there's one study in particular that really took a good look at this. It was published in the Journal of Physiology, and it took a look at something entirely different from what we're used to seeing.

You see, normally the argument for fasted cardio is really simple. It's kind of bro science, but it kind of makes sense at the same time. People will say that fasted cardio is good simply because you're burning through all of your glycogen. Glycogen is your stored carbohydrates in your muscle. So they say that because you're training in a fasted state, you burn through that glycogen, and your body has no choice but to start burning fat because you've already gone through the glycogen. That's a simple theory, and it kind of makes sense, but it's not the truth. That's not why fasted cardio is better. That's not how it works.

So what this study looked at is it looked at something known as intramyocellular lipids. You see inside of our muscles, we have little itty bitty, teeny, tiny bits of fat.


1) Muller AF , et al. (n.d.). Ghrelin drives GH secretion during fasting in man. - PubMed - NCBI. Retrieved from

2) Nørrelund H , et al. (n.d.). The protein-retaining effects of growth hormone during fasting involve inhibition of muscle-protein breakdown. - PubMed - NCBI. Retrieved from

3) Pan JW , et al. (n.d.). Human brain beta-hydroxybutyrate and lactate increase in fasting-induced ketosis. - PubMed - NCBI. Retrieved from

4) Very-low-carbohydrate diets and preservation of muscle mass. (n.d.). Retrieved from

5) Exercise in the fasted state facilitates fibre type-specific intramyocellular lipid breakdown and stimulates glycogen resynthesis in humans. (15, April). Retrieved from

6) Hormone-sensitive lipase - an overview | ScienceDirect Topics. (n.d.). Retrieved from

Is Fasted Training Better for You?

Get the breakdown on training fasted. HYLETE Community Captain Thomas DeLauer will explain the three main reasons why you might consider fasting while training. While debunking common fasting myths, DeLauer also explains the science and research behind fat burning. Make sure to follow these tips if you want to stay in tip top shape.

5 Reasons You should ALWAYS Workout During a Fast [Burn more fat]

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5 Reasons You should ALWAYS Workout During a Fast [Burn more fat] - Thomas DeLauer

1) More Fat Loss

You’re exercising with your insulin and leptin levels at baseline, allowing for more fat burning to occur

Perfect study for this section is the intramyocellular lipids one, which shows the big difference between the two:

Study - The Journal of Physiology

During F but not during CHO, the exercise bout decreased IMTG content in type I fibres from roughly 18% to 6% area lipid staining

2) More sensitivity Post workout in order to build muscle

You can enhance this effect by working out fasted, which results in greater increases in p70s6k


Study - European Journal of Applied Physiology

Found: Increased p70s6k phosphorylation during intake of a protein–carb drink following resistance exercise in the fasted state - fasted training group saw a bigger increase in p70s6k

3) Get to take advantage of less fat cell sensitivity

Weight Lifting & Insulin

A study from the journal Diabetes found that strength training increases protein content of GLUT4, insulin receptor, protein kinase B-alpha/beta, glycogen synthase (GS), and GS total activity

Specifically, found that strength training for only 30 min three times per week is enough to see increases in insulin action in skeletal muscle

4) Cardio Increases Autophagy

It’s well known that fasting increases markers for autophagy (don’t yet have a direct way of measuring autophagy) and cardio boosts markers for autophagy as well

A study from the journal Autophagy found that exercise induces autophagy in peripheral tissues, such as muscle, liver, pancreas and adipose tissue, and in the brain


Fasting & BDNF

BDNF levels can be different in different places - you have blood BDNF levels, CSF BDNF levels (CSF is cerebrospinal fluid; a clear, colorless body fluid found in the brain and spinal cord) and BDNF levels in various brain locations

Fasting has been shown in many studies to increase BDNF - in fact, a study published in the Journal of Neurochemistry found that intermittent fasting increased the production of BDNF by 50 to 400%, depending on the brain region

Exercise & BDNF

Exercise induces neurogenesis, or the creation of new neurons - the new neurons are created in the hippocampus, the center of learning and memory in the brain

At a cellular level, it is possible that the mild stress generated by exercise stimulates an influx of calcium, which activates transcription factors in existing hippocampal neurons

The transcription factors initiate the expression of the BDNF (Brain-Derived Neurotrophic Factor) gene, creating BDNF proteins that act to promote neurogenesis

Thus the generation of BDNF is a protective response to stress, and BDNF acts not only to generate new neurons, but also to protect existing neurons and to promote synaptic plasticity

It has been shown that physically active people recover from mild depression more quickly, and physical activity is strongly correlated with good mental health as people age


it’s been shown that HIIT leads to greater increases in BDNF than LISS as it places more stress on the body:


A study published in the journal Medicine and Science in Sports and Exercise looked at the effects of HIIT vs LISS on BDNF levels in 15 volunteers

On separate days, two subsequent 30-min endurance rides were performed at 20% below the VTh (VTh - 20) and at 10% above the VTh (VTh + 10)

BDNF values increased from baseline after exercise at the VTh + 10 (13%) and the GXT (30%). There was no significant change in BDNF from baseline after the VTh - 20. Changes in BDNF did not correlate with VO2max during the GXT, but they did correlate with changes in lactate

The fasted state (overview)

this video summarize the events happening in the fasted state

Fasted State

How do metabolites of the muscle, brain, and kidney interact in the fasted state?

Fasting State in Liver



Below is a video that goes over every major metabolic pathway that occurs in the human cell in 34 minutes!



Krebs Cycle/ETC


Lactic Acid Fermentation and the Cori Cycle

Glycogen Metabolism (Glycogenesis and Glycogenolysis)

Pentose Phosphate Pathway

Fatty Acid Oxidation (Beta Oxidation)

Fatty Acid

Cholesterol Synthesis


Amino Acid Biosynthesis Metabolism

Nucleotide Biosynthesis and Degredation Metabolism

Nitrogen Metabolism (transamination, oxidative deamination, urea cycle)

Urea Cycle

Glycolysis and Gluconeogenesis Enzyme Regulation (PFK1, PFK2, F16BPase, F26BPase)

Pathophysiology of Type 2 Diabetes (my theory on the cause and how to prevent diabetes)

Fasted State Metabolism MCAT (Gluconeogensis, Beta Oxidation, Lipolysis, Ketogensis, Glycogenolysis)

Video that was an introduction of Fed State vs Fasted State Metabolism

Video that goes into details of the Fed State of Metabolism

Below is a video link that goes over every single major metabolic pathway you need to know for the MCAT!!

Do You Walk In A Fasted State?: Intermittent Fasting Viewer Q&A

I am not sure if you’ve already answered this on your channel but do you walk in a fasted state to improve fat loss or did you walk whenever you had the time, regardless of whether you were fasting or feeding?

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Intermittent fasting for women.

How does the heart use energy? Glucose and Fatty Acids - Fasted State - Creatine

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Training in a fasted state

Should you be training in a fasted state? Are you someone who attends the morning classes at your gym? Is not eating prior to attending these classes hurting your performance gains? This week on the Knowledge Bomb Coach Nick Fowler talks about a couple of ways to find out if your body can adapt to an early training regimen



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