Do Your Genes Make You Fat? - with Giles Yeo
Are your genes to blame when your jeans don't fit? Giles Yeo explores the role of genetics in appetite control and obesity.
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While the obesity epidemic is a contemporary problem, undoubtedly due to changes in our lifestyle and in the types of food we eat, differences in our genetic make-up mean some of us eat more than others. Join geneticist and neuroscientist Giles Yeo as he discusses how we use genetics as a tool to understand the biological variation in appetite control.
Giles Yeo is a neuroscientist and geneticist at the University of Cambridge. He is a Principal Research Associate and group leader at the University Metabolic Research Labs, studying brain control of food intake and bodyweight. He is also director of the Genomics and Transcriptomics core facility.
This talk and Q&A were filmed in the Ri on 26 January 2018.
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Weight Gain: Can you Store Fat in Specific Areas
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Weight Gain: Can you Store Fat in Specific Areas- Thomas DeLauer… Can you store body fat in a specific area of your body? That's a big question, and a lot of people ask me, Hey, Thomas, I store body fat in my legs, or I store body fat in my arms or in my abdomen. Is there any way that I can change that? Well, the short answer is kind of yes and no. You see, a lot of it ends up being dictated, of course, by our genetics, but I know that's not the answer that you want to hear.
So, in this video, I'm going to break it down beyond genetics. I'm going to break it down to some hormones. I'm going to help you understand why you might be storing fat in a specific area and maybe a couple things that you can start to control that might help that situation out. Hey, if you haven't already, I do encourage you to subscribe to my channel so that you can make sure you see all the videos that I post every single week, and please turn that little bell on so you can turn on notifications to know whenever I post a new video.
All right, so first and foremost, we do have to look at DNA. I want to get this out of the way. First off, we have to understand that over 50% of the actual fat storage different that occurs in our body is truly dictated by our genetics, and when it comes down to gender differences, sometimes it can be as much as 70% dictated by our genetics with that remaining 30% having to do with age, having to do with ethnicity and a number of other, still, genetic factors. So the reality is, yes genes play a big role in it, but we do have some other catalysts at play.
One in particular is one that you know of, cortisol. You see, cortisol is a stress hormone. We all hear the ads, we've seen the marketing that talks about cortisol and belly fat, but the reality is, it is kind of true and here's how it works. You see, cortisol exerts a very powerful effect on adipose tissue metabolism, and it's all because of something known as glucocorticoid receptors. You see, cortisol is a glucocorticoid, and we have specific receptors that are in our fat cells called glucocorticoid receptors.
These glucocorticoid receptors receive a message from cortisol and then store fat in a specific way. Well, since fat already has a glucocorticoid receptor in it, the more fat that we accumulate, the more glucocorticoid receptors we have, and the more cortisol we receive and the more fat we deposit. So, since cortisol acts via the glucocorticoid receptor, it actually triggers something known as a lipoprotein lipase, and when lipoprotein lipase acts within this continuum of glucocorticoids, it has a variable density in different areas of the body in which it deposits fat.
So it goes through a specific order. It actually starts with visceral adipose tissue, which is the fat that is underneath our skin, but even one step further, surrounding our organs at the very far interior of our body. Then, the next place that [replaces 00:02:32] it is good old fashion abdominal subcu fat, which is traditional abdominal fat. Then, the next order of business after that is going to be femoral subcu fat, so that's more fat that's going to be stored in the legs. There's actually an order, so when it comes down to proving the relationship between hormones and where we store fat, cortisol is really the only one that is tried and true, and proven, to really cause body fat to be stored in a specific area.
1) Hormonal control of regional fat distribution. BjÃ¶rntorp P. Hum Reprod. 1997 Oct;12 Suppl 1:21-5.
2) Hormones and body-fat distribution. (2017, May 12). Retrieved from
3) Woodhouse LJ , et al. (n.d.). Dose-dependent effects of testosterone on regional adipose tissue distribution in healthy young men. - PubMed - NCBI. Retrieved from
4) Ho KY , et al. (n.d.). Effects of gender and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations. - PubMed - NCBI. Retrieved from
5) BL, W. (n.d.). Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. - PubMed - NCBI. Retrieved from
6) P, B. (n.d.). Hormonal control of regional fat distribution. - PubMed - NCBI. Retrieved from
7) De Pergola G , et al. (n.d.). Free triiodothyronine and thyroid stimulating hormone are directly associated with waist circumference, independently of insulin resistance, metabo... - PubMed - NCBI. Retrieved from
HOW I CHANGED MY FACE ?!
Ive been focusing on losing fat off of my face for the past 3 years and im really proud of the results i want to share with you guys my journey. on my channel i have a series called Road to Cheekbones in the beginning alot of people were skeptical and couldnt see what I see but I knew i could transform my face by losing fat and dialing in on my nutrion and exercise. Im going to share with you my journey and what I did so that you can do the same. I hope this helps you and encourages you to be the best version that you can be!. Cheers to Road to Cheekbones Season Finale 2.5 !
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What Does Starvation Do To The Body?
We all know what hunger feels like, but what happens to our bodies if we stop eating? What exactly is the science behind starvation?
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How Long Can a Person Survive Without Food?
“The duration of survival without food is greatly influenced by factors such as body weight, genetic variation, other health considerations and, most importantly, the presence or absence of dehydration. For total starvation in healthy individuals receiving adequate hydration, reliable data on survival are hard to obtain.”
The Psychology of Hunger
“In November 1944, 36 young men took up residence in the corridors and rooms of the University of Minnesota football stadium. They were not members of the football team. Rather, they were volunteers preparing for a nearly yearlong experiment on the psychological and physiological effects of starvation. Known as the Minnesota Starvation Experiment, the study was a project of the newly established Laboratory of Physiological Hygiene at the University of Minnesota, an interdisciplinary research institution with an emphasis on nutrition and human biology.”
Brain Foods: The Effects of Nutrients on Brain Function
“It has long been suspected that the relative abundance of specific nutrients can affect cognitive processes and emotions. Newly described influences of dietary factors on neuronal function and synaptic plasticity have revealed some of the vital mechanisms that are responsible for the action of diet on brain health and mental function. Several gut hormones that can enter the brain, or that are produced in the brain itself, influence cognitive ability.”
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BAD GENETICS AREN'T AN EXCUSE
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What Happens to Your Body on Steroids?
What happens inside your body when you take steroids? Find out all the benefits and side effects of steroid use. If you're wondering if you do lose muscle when you stop taking steroids or testosterone injections this video will help. Whether you're trying to learn more about anabolic steroids or the effects that large doses of testosterone and sarms have on your body, this video will help.
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Steroids can help you build a massive amount of muscle, increase your strength, and drastically speed up your recovery. But they can also come with some serious side effects, especially for many beginners that rush in without knowing what they're doing. So today i want to go over exactly what happens to the human body on steroids based on science. Now before we jump in I want to mention that I don't personally have any first-hand experience with steroids, but I have spent countless hours researching the topic, so I'll do my absolute best to give you a non-bias science-based summary of the effects that steroids have on your body.
Now the first thing you have to know is that not all steroids are the same. The term “steroid” refers to a biologically active organic compound with four rings arranged in a specific molecular configuration. So even a corticosteroid is still considered a steroid since it has this same kind of four ring structure and corticosteroids are considered relatively safe. They're even routinely prescribed by doctors to help lower inflammation in the body, caused by things like swelling due to an injury, allergic reactions, and even asthma. Although many of you already know about corticosteroids, it may surprise you to learn that both cholesterol and estrogen are actually also considered steroids because they have the same four rings, but for the rest of the video when I say steroids I'm referring to the type of steroids that are predominantly used for enhancement purposes known as an anabolic-androgenic steroid. This is a type of steroid that mimics the effects of testosterone in your body.
Normally your testes will produce four to nine milligrams of testosterone per day in an average healthy male. But by taking synthetic testosterone, you'll vastly increase the amount of testosterone that flows through your veins. Your body then treats that exogenous testosterone in the same way as if it were your body's own testosterone. So the testosterone enters your cells and binds to what's known as androgen receptors. From there, it binds to the nucleus of the cell and attaches to DNA. This process activates hundreds of genes involved in stimulating protein synthesis and reducing protein breakdown.
So as a result, your muscles are more likely to stay in a positive protein turnover rate,” which benefits muscle growth because to build muscle, more protein needs to be built up compared to the amount that gets broken down. And this is how steroids assist with muscle growth, and why they're so popular amongst bodybuilders.
Now aside from improving protein turnover rate anabolic steroids also increase the number of nuclei that are found within muscle cells. Those nuclei, which are actually called myonuclei, happen to be the control center of each muscle. So having more nuclei is beneficial because the number of nuclei you have within a muscle is actually one of the primary factors that determine your potential for growth. To put it simply the more myonuclei, the bigger the muscle can become. (3) And this is actually one reason why some people have better muscle-building genetics because they naturally have more myonuclei, while others don't. (4) You see, the nuclei in your muscle fibers are limited to a maximum region of the cell that they can control. This is an area known as the myonuclear domain. Once the growth of a particular muscle fiber exceeds this domain, the only way to further grow is to add new nuclei to that cell. And that process is called 'myonuclear addition.'
Now the problem is that normally, it takes a lot of time to add new nuclei to a muscle. That’s why you can’t gain 20 pounds in let's say one month. But by taking steroids, you can gain muscle much faster because it significantly increases the speed at which your body can add new nuclei to muscle tissue. And once it's there the new nuclei remain in your muscle tissue for the rest of your life. We can see this play out in studies in which steroids were given to mice. 3 months after stopping the use of steroids, the mice had their muscle mass return to normal, but the extra nuclei stayed there. (5) That’s why taking steroids not only increases muscle mass in the short term, but it can also increase the amount of muscle that you can build and maintain for the rest of your life. So even if someone that once took steroids stopped taking steroids, they would most likely lose some mass, but their muscles would still have a higher number of nuclei.
Understanding Your Genetics | Muscle Genetics Science Explained feat. My Mom!
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These Genes Determine How Your Body Regulates & Distributes Fat
These Genes Determine How Your Body Regulates & Distributes Fat.
We all know that our DNA can influence our health in myriad ways. This is true in the case of allergies—which you are more likely to have if someone in your family has them—and diseases like breast cancer. The connection is also present when it comes to metabolism and ability to maintain a healthy weight—although there's still a lot we don't know about the specifics of this connection.
But now, a new study published in Nature Genetics takes our knowledge a step further, by identifying multiple genetic variants that determine how the body regulates and distributes fat tissue.
The study, authored by scientists from the Genetic Investigation of Anthropometric Traits consortium, identified 24 positions on chromosomes—15 of which are common and nine of which are rare—that predispose a person to a higher waist-to-hip ratio, which is considered a good way to detect obesity. These genes affected metabolism, regulation of body fat, bone growth, and a hormone that helps control glucose levels and fat breakdown.
You might wonder how locating these genetics variants will help us. The short answer is that understanding the science of these variants can help explain why obesity so often leads to diseases like type 2 diabetes and heart disease. The long answer is that in the future, we might be able to develop therapies that target these variants, especially the common ones, in some way to prevent or treat obesity.
But what about the ones that aren't common? For the first time, we were able to examine, on a large scale, how low-frequency and rare variants influence body fat distribution, explained Kari E. North, lead author of the study and professor of epidemiology at UNC Chapel Hill (where many of the scientists in the consortium are based). These variants are rarer in the population, but the effects they have on individuals are much larger, possibly making them more clinically relevant.
In other words: They affect very few people but for those people, treatments that target these variants could be life-altering.
The more we know about how our DNA affects our ability to maintain a healthy weight, the closer we are to helping the two out of three adults that are considered to be overweight or have obesity. It's going to be a long road, but this study brings us one step closer to solving the puzzle and makes clear that when it comes to obesity, both nature and nurture matter.
In the meantime, it's important to focus on how we can prevent obesity from an environmental or nature perspective, instead of a genetic one. Regularly moving your body, eating a plant-based diet full of healthy fats, lean proteins and healthy carbs, and managing stress are all science-backed ways to maintain a healthy weight.
Here are some good weight loss programs, completely natural.
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Everything Body Fat Distribution Tells You About You
Watch the full video for the tips and tricks on what does your body fat distribution tells you about you.
Everything you need to know about fat types, location, and keeping it off.
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Why You're Fat and He's Lean | What The Science Says
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0:00 - The Hypothalamus Mystery
1:42 - Bodyweight Regulation Mechanisms
3:28 - Leptin Explained
7:22 - Variation In Humans
8:40 - How To Change Your Bodyweight Set Point
11:51 - Are we screwed?
What is ANDROID FAT DISTRIBUTION? What does ANDROID FAT DISTRIBUTION mean?
What is ANDROID FAT DISTRIBUTION? What does ANDROID FAT DISTRIBUTION mean? ANDROID FAT DISTRIBUTION meaning - ANDROID FAT DISTRIBUTION definition - ANDROID FAT DISTRIBUTION explanation.
Source: Wikipedia.org article, adapted under license.
Android fat distribution describes the distribution of human adipose tissue mainly around the trunk and upper body, in areas such as the abdomen, chest, shoulder and nape of the neck. This pattern may lead to an apple-shaped body or central obesity, and is more common in males than in females. Thus, the android fat distribution of men is about 48.6%, which is 10.3% higher than that of premenstrual women. In other cases, an ovoid shape forms which does not differentiate between men and women.Generally during early adulthood, females tend to have a more peripheral fat distribution such that their fat is evenly distributed over their body. However, it has been found that as females age, bear children and approach menopause, this distribution shifts towards the android pattern of fat distribution resulting in a 42.1% increase in android body fat distribution in postmenstrual women. This is to help centre a woman's gravity making her more stable when carrying offspring.
Android fat distribution is contrasted with gynoid fat distribution; fat around the hips, thighs and bottom, causing a pear-shape. This more female-patterned fat distribution has been linked to risk factors for cardiovascular disease, in both males and females. Android fat tends to be associated with cellulite, and lumpy appearance of the skin - usually undesired by women. This article will look at cosmetic implications of such subcutaneous fat such as liposuction.
Jean Vague, a physician from Marseilles, was one of the first individuals to bring to attention the increased risk of developing certain diseases in individuals with an android distribution compared to a gynoid distribution. For example, Diabetes and Gout. There are other health consequences beyond these, including psychological consequences.
Android fat is readily mobilized by deficits in energy balance. It is stored in different depots to gynoid fat.
Android fat cells are mostly visceral - they are large, deposited deep under the skin and are highly metabolically active. The hormones they secrete have direct access to your liver. The presence of fat in the trunk and upper body in males is facilitated by testosterone. Testosterone circulation causes fat cells to deposit around the abdominal and gluteofemoral region, whereas in women oestrogen circulation leads to fat deposits around areas such as thighs, breasts and buttocks. Therefore, measuring a person's oestrogen to testosterone ratio can reveal their predicted gynoid to android fat distribution. Android fat develops as a back-up source of energy when the male body is experiencing an imbalance, whereas gynoid fat develops after puberty, in order to better prepare the body for supporting a potential infant. 50% of the variance in abdominal fat mass observed in humans is due to genetic factors
The cellular characteristics of adipose tissue in android and obese women are different. Android type have larger fat (Hypertrophy) cells whereas gynoid type have increased number of fat cells (Hyperplasia). This allows for hypertrophic obesity and hyperplastic obesity. Two different receptors, alpha and beta fat cell receptors, vary in their ability to facilitate or inhibit fat mobilization. Alpha-receptors are predominately in the lower body thus more abundant in gynoid patterns and Beta-receptors are predominantly in the upper body and so more abundant in android patterns.
Hormonal disorders or fluctuations can lead to the formation of a lot of visceral fat and a protruding abdomen. Medications such as protease inhibitors that are used to treat HIV and AIDS also form visceral fat. Android fat can be controlled with proper diet and exercise. A poor diet with lack of exercise is likely to increase android fat level.
The Truth About Genetics
Hi babes ???? I hope this video explains some of the questions you have and gives you hope towards your own journeys. We can all win ????
Just to clarify- this is NOT a video @ my haters. This video is for those who needed a reminder that working out will change your body. It is possible. I wish I would have had this reminder a few years back ????
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Study Finds Link To Stubborn Fat In Genes
CBS2's Dr. Max Gomez has the latest on a study explaining why some people's genes are to blame for making it harder to lose weight.
Low Body Fat But No Abs? (3 REASONS WHY!)
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Low Body Fat But No Abs? (3 REASONS WHY!)
Lean but no abs? There are a few main reasons why this might be the case...
Reason #1: Your body fat percentage is not as low as you think.
Most people way over-estimate how lean they truly are. In my experience, if you take most people's estimated body fat percentage and add 3-5% extra to it, that's usually closer to what they actually are.
Many people complain about having a low body fat percentage but no abs, when in reality they're well above the 15% body fat level needed in order to simply START seeing six pack abs poking through.
Just how lean to see abs clearly? For well defined six pack abs (when flexing) you'll likely need to be somewhere between 10-12% body fat, which is quite lean and not easy to accomplish for most.
In most cases, if you think you have low body fat but no abs, the simple truth is that you don't actually have low body fat to begin with.
Reason #2: Your body stores a higher percentage of fat on your stomach.
Everyone stores their fat a bit differently throughout their body (this is mostly determined by genetics), and this will affect just how low your body fat percentage needs to be in order to see your abs.
If your body preferentially stores a much higher amount of your adipose tissue as belly fat (such as in my own case) getting clearly defined six pack abs is going to be a longer road and a bigger challenge.
14% body fat but no abs? 12% body fat but no abs? Assuming you're truly at those body fat levels, it could just be that your individual fat distribution does not flavor having a very lean stomach.
You can certainly still get there with enough effort if you truly want to, but you're going to need to lower your overall body fat percentage lower than the average person.
Reason #3: Your abdominal muscles are not sufficiently developed.
If you truly have low body fat but no abs, part of the reason may just be that you need to perform a higher amount of direct ab exercises and ab workouts in order to really get them to show through.
Compound movements provide some stimulation, but it's not enough to maximize abdominal development and really carve out that clear separation you're after.
High rep ab circuits are not ideal - the abs should be treated just like any other muscle and trained through progressive resistance training in the same way. I recommend 10-15 reps per set going within a few reps of failure.
Some of my favorite ab exercises include kneeling rope crunches, hanging leg raises, reverse crunches and plank variations.
So, if you have low body fat but no abs, those are the 3 things to examine. If all 3 are taken care of then you'll be on the proper path toward your goals. Hope you found this helpful.
How Body Recomposition ACTUALLY works (And how to know if YOU can do it)
Many people have certain misconceptions about body recomposition and about the prospect of losing fat and building muscle at the same time.
Contrary to popular belief, it's not about turning fat into muscle, but rather, simply achieving muscle growth without having as many conditions optimized for muscle growth (such as in the case of bulking)
In this video we will discuss this and many other topics on the theme of body recomposition and building muscle while losing fat
0:55 - What people think body recomposition means and what it actually is
1:15 - Breaking down what needs to happen for muscle growth
2:15 - What things determine whether you can recomp
4:35 - Talking about caloric deficit amounts and body recomp
7:13 - Who can and who cannot build muscle in a deficit
10:08 - Examples of people who can recomp realistically
18:00 - What about recomping at caloric maintenance?
20:08 - Being more or less advanced in specific body-parts
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How to Lose Stubborn Body Fat
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Are Your Genetics KILLING Your Gains?
Ever wondered if you have good enough genetics to actually build muscle? If so, this is the video you need to watch. Jeff Cavaliere and Jesse Laico dive into the viewer mailbox to answer the question of what can be done if your genetics for building muscle just aren’t so great.
The reality is, far too often people try and simplify one of the most complicated phenomena in the human body - genetics. It is not as simple as having either good genetics or bad genetics. Instead, you may have elements of your genetics that are favorable for building muscle and getting ripped while others are not nearly as gifted.
Instead of looking at yourself as either a Lamborghini or a Prius you have to realize that no matter what model car your body resembles at the moment you can quickly improve it - just as if you were to upgrade to a better package on the model you have now.
As with any discussion of genetics however, there are intangibles and outside factors that influence that way your genetics express themselves. If you do these things right, the expression of your genes can wind up with an entirely different outcome than you would expect.
Let’s discuss some of the things that are hard coded however and not likely to be influenced by anything other than picking your parents. These are called anthropometric factors. Things that influence your body structure, dimensions and proportions. Bone structure and skeletal width are very important factors. Let’s face it, if you are 5 foot 7 and have narrow shoulders you will never have the muscle mass like the Rock.
He simply has a much wider, broader skeleton that allows him to pack on much more muscle than you do. Now that doesn’t mean that you can’t optimize the amount of muscle that you can put on your frame and look amazing at the end of the day.
Other things like the torso to lower body ratio can dramatically impact leverages and your ability to lift strongly. It leads to reason that if you have better leverage to perform more powerful lifts that you will have an easier time building muscle through overload than someone who has very unfavorable limb lengths.
It goes even further…
If you have poor distribution of androgen receptors within your muscle bellies you simply won’t respond hormonally to training as a stimulus as someone who has a greater density of them. Likewise, if your muscles are made up of a much higher proportion of type I fibers rather than type II, your ability to be explosive and carry more muscle as a result will be lower.
These are things that you cannot change much, if at all, so it doesn’t merit much focus in your training.
The things that can be changed however are your willpower and consistency of training. I don’t care what your genetics look like, if you are willing to commit to a consistent workout program or schedule and get yourself in the gym on a regular basis to train hard and smart - you will have better results than most who don’t or aren’t willing to do the same.
Likewise, if you have a greater capacity to remain focused during a session or have a higher threshold for pain and training discomfort you will likely be able to push yourself harder than the next person and get a greater stimulus for growth from your workouts.
Of course, what you do outside the gym matters immensely in other areas as well.
What does your nutrition look like? Are you eating well enough to support your hard training in the gym? Are you getting adequate sleep to promote optimal recovery from your workouts which will help you to recover faster and see better gains because of it.
The bottom line is this, instead of looking to others and idolizing their results in comparison to yours, focus on yours alone and look for ways to optimize them. I promise you this, if you do, the results you achieve will be nothing short of amazing and better than you ever could have imagined. If you’re looking for your question to be answered in a future episode of AX JEFF, be sure to leave a comment below this video and you might be selected next.
For a step by step muscle building program and meal plan to help you get the most out of your genetics, be sure to visit athleanx.com via the link below and remember to use the program selector to find the workout plan that best matches your current goals.
For more videos on how to build muscle and how much genetics has to do with the size of your biceps, be sure to subscribe to our channel here on youtube via the link below and remember to turn on your notification so you never miss a new video when it’s published.
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Is GENETICS STOPPING Your FAT LOSS & MUSCLE BUILDING
Tired of blaming Your Genetics..Can Genetics Influence Your rate of fat loss or muscle building? Lets find out..
Presented By - Dr.Sathish
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Checkout attribution for Creative Commons Images used in this video in the description Below.
FAT CELL - Blausen.com staff (2014). Medical gallery of Blausen Medical 2014. WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN 2002-4436.
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VITRUVIAN PHYSIQUE || Model of Genetics
Welcome to my channel. My name is Harlenee and today I will be talking about the Vitruvian Model of Genetics by Vitruvian Physique (
#Vitruvianphysique #vitruvianmodelofgenetics #genetics #bodyfatdistribution #bonestructure #musclecomposition #fatloss #spotreduction #bodypositivity #selflove #selfcompassion