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Importance of Vitamin D to fight against Corona

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कोरोना पर असरदार Vitamin D | Importance of Vitamin D to fight against Corona | #CORONA

Importance of Vitamin D to fight against Corona

As the Corona pandemic goes on increasing it is important for us to take care of ourselves and boost our immune system.
One such important aspect to have a good immune system is the presence of Vitamin D in our body.

Dr. Amol Annadate has discussed the importance of Vitamin D for increasing immunity and also ways by which we can obtain this important Vitamin in the right proportion.

00:30 How does vitamin D help in fighting Corona?
1:40 What part of the body or process does Vitamin D help in a human body?and what all disease it can help against?
2:15 How should we take Vitamin D naturally?
3:25 How much Vitamin D should we take and what tablet to take?
4:32 When should we eat the tablet?

#StayHomeStaySafe #coronavirus #latestnews

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Importance of Vitamin D in small children.
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Vitamin D, Immune System & SARS-CoV-2 (COVID-19) | Mechanism of Vit D Immune Regulation & Overview

Vitamin D, Immune System & SARS-CoV-2 (COVID-19) | Mechanism of Vit D Immune Regulation, Overview of Evidence

In this lesson, I discuss the vitamin D its immune system regulation, specifically with regards to how vitamin D can help protect against respiratory tract infections like SARS-CoV-2 (COVID-19).

1) Brief Introduction to Vitamin D and SARS-CoV-2

2) Vitamin D deficiency and increased risk of infections

3) Vitamin D supplementation and protection against acute respiratory tract infections

4) Vitamin D and Immune System Regulation (including cytokines like IL-6)

5) Vitamin D and SARS-CoV-2 (COVID-19), comorbidities and associations

3) Summary of some Remdesivir data in in-vitro and in-vivo (mice and rhesus monkeys) studies used in treatment of other coronaviruses like SARS-CoV and MERS-CoV

****EXCLAIMER: The content (ex. images) used in this lesson are used in accordance with Fair Use laws and is intended for educational purposes only.****

*DISCLAIMER* Although there has been a meta-analysis showing reduced risk of acute respiratory tract infections with daily/weekly recommended doses of Vitamin D, WE DON’T have enough evidence to say that Vitamin D is protective against SARS-CoV-2 (COVID-19) – WE ONLY HAVE ASSOCIATIONS/CORRELATIONS at this point.

***This video is merely here to PRESENT INFORMATION from the studies quoted in this video - if people have an issue with the data, I would suggest they read over these studies and contact the experimenters/authors****

I hope you find this lesson helpful! If you do, please give this video a thumbs up and consider subscribing to the channel – all of your support is greatly appreciated!
JJ

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Check out some of my other lessons.

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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*
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Could Vitamin D Help Fight COVID-19?

My opinion is that you keep the correct levels of vitamin D in your body. Now a days, due to staying indoors, it is possible that you will develop the deficiency of vitamin D. Get this checked by your doctor and use the correct dose to stay healthy.

Looking to support my work? Here is the link to donate:

Here are my notes:
Daily 10 microgram or 400 IU/Day

Lippincott’s Biochemistry Review 4th Edition. Page 388
Daily 5 mg of cholecalciferol or 200 IU of Vitamin D.

However, 800 IU/Day is shown to reduce the incidence of osteoporotic fractures.
800 IU/Day recommended by the Institute of Medicine to maintain bone health.

Frank deficiency is when the levels of 25-hydroxycholecalciferol (25OHD) is less than 20 ng/mL (50 mmol/L)


No consensus that the oral vitamin D supplements are helpful

Ergocalciferol from plants is called Vitamin D2
Cholecalciferol from the animal tissue is called Vitamin D3

7 deidro-cholesterol to (UV light) to cholecalciferol (D3) to 25 hydroxylase in liver to 25 OH D to -hydroxycholecalciferol 1-hydroxylase in kidney to 1,25 DiOH D3




Vitamin D Receptors are abbreviated to VDR in the notes. These are cytosolic receptors.


Deficiency of vitamin D makes people more susceptible to respiratory tract infections.
Vitamin D supplement can reduce these infections by 12%
Keep in mind, this is for those who are deficient in this vitamin. If you are not deficient, then it will not make a difference. Because, you are already good.
Evidence is not sufficient to say that vitamin D helps prevent respiratory infections.

2018 Study

People with autoimmune diseases commonly have hypovitaminosis D

What are cathelicidins?


What are beta defensins?



2011 Study


Activation of TLR and PAMPs on macrophages increases the production of 1, alpha hydroxylase and the VDR. This in turn causes more production of cathelicidine and beta defensins 4.

Vitamin D also affects monocytes to reduce production of IL1, IL6, IL8, IL12, and TNF. Regulating the immune response.

Vitamin D acts on the dendritic cells to inhibit/reduce their differentiation and maturation. It reduces their MHCII expression, co-stimulatory molecules like CD40, CD80, CD86, decreased production of IL-12 etc.

2013 Study

Vitamin D improves immune system by helping produce cathelicidine and by helping modulate inflammatory cascade. Especially for the respiratory infections.
It also helps produce NFk-B (nuclear factor kappa light chain for activated B cells.)

(
Notes about the NFkB

Helps with cytokine production and cell survival.
NFk-B factor becomes active when T and B cell receptors become active. Its activation causes the gene expressions that allow T cell development, maturation, and proliferation.
T and B cells have Vitamin D receptors that help them produce NFk-B
)

Continuing the notes from the study:
In pulmonary infections. Lung epithelial cells are able to convert inactive vitamin D to its active form. This active Vitamin D then helps produce cathelicidine. Which helps kill the pathogens.

Vitamin D seems to favor TH2 and TH17 cell activation which is anti-inflammatory profile.
Vitamin D seems to reduce the activation of TH1 cells which are pro inflammatory by their IFN-gamma action.
A deficiency of vitamin D may dysregulate the inflammatory response of the body.

Vitamin B also increases the IkBa. This leads to inhibition of NFkB. This helps reduce the production of IL6 and IL8 by inhibiting the production of NFkB.
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Explained: Does Vitamin D protect against coronavirus disease?

As Covid-19 cases surge across the world, data from 20 European countries showed that nations with low levels of Vitamin D had higher Covid related death rates. So how exactly does Vitamin D aid in the battle against Covid and is it enough to protect one from being infected by coronavirus? Watch this video to find out.
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Vitamin D can be deficient in COVID-19 hospitalized patients

Millions of people in various countries are spending time indoors due to coronavirus pandemic.

Lack of sunlight on the skin may mean that many of us may not be getting enough vitamin D.

Public Health England recently asked people to consider taking vitamin D supplements.

They recommend taking 10 micrograms of vitamin D a day. This advice includes pregnant and lactating women.

Babies up to the age of 1 year need 8.5 to 10 micrograms of vitamin D a day.

Vitamin D helps regulate calcium and phosphate levels in our bodies.

Appropriate calcium levels help keep our bones, teeth, and muscles healthy.

Vitamin D is also critical for a balanced immune response to infections.

...

Vitamin D and COVID 19 | COVID Vitamin D Relationship | Does Vitamin D prevent Coronavirus

Does Vitamin D protect against SARS CoV-2 - A detailed Analysis and what to do?
This Topic and Video was inspired by my dear Elder Brother and Friend Dr Adil Haroon Khan. Who has numerous other ideas on how to deal with the COVID 19 situation.

He is proposing use of Antihistamines, vitamin D 800-2000 units, inhaler (salbutamol & ipratropium) and montelukast for early management of respiratory symptoms in Covid patients.

He is always an inspiration - Ckeck out his video

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Vitamin D might just save you from getting Covid-19

There may be a cheap and effective way to help prevent getting infected with Covid-19 and fighting it if you’ve already been infected. Taha Meli Arvas explains, In Brief.

All other episodes of ‘In Brief’
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#Covid19 #VitaminD #Coronavirus

Vitamin D for respiratory infections: Coronavirus Pandemic—Daily Report with Rishi Desai, MD, MPH

For more info and resources:

#RaiseTheLine #FlattenTheCurve

Stay on top of the latest COVID-19 news with the Osmosis Coronavirus Pandemic Daily Report. In each report, Osmosis Chief Medical Officer Rishi Desai, MD, MPH, will deliver a short, focused explanation of a specific COVID-19 topic, and provide updates on the current status of the pandemic, both within the US and globally.

Today's update focuses on COVID-19 and the use of Vitamin D for respiratory infections.

For more on today's episode please refer to:





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Medical disclaimer: Knowledge Diffusion Inc (DBA Osmosis) does not provide medical advice. Osmosis and the content available on Osmosis's properties (Osmosis.org, YouTube, and other channels) do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed health care provider. Always seek the advice of a physician or other qualified healthcare provider with any questions you have regarding a medical condition.

Vitamin D & COVID-19: Dr. David Meltzer discusses benefits

Dr. David Meltzer of the University of Chicago joins WGN Evening News to discuss how a proper Vitamin D level can help play a role in reducing one's risk to COVID-19.

Vitamin D and coronavirus: Sunlight and nutrition could help boost immunity | ABC7

Some studies have found that patients who were hit hardest by COVID-19 had low levels of vitamin D in their bodies. A SoCal doctor is explaining why this might be the case and what we can do to boost our vitamin D levels. Details:
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How Does Vitamin D Help Us Fight COVID?

Dr. David Metzler from the University of Chicago joins to share about the findings of his recent study, which found that patients who were vitamin D deficient were about 77% more likely to test positive for COVID than patients who weren’t. There are many ways to get vitamin D, including the sun, vitamin D fortified foods, and supplements.

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The Doctors is an Emmy award-winning daytime talk show hosted by Dr. Ian Smith. The Doctors helps you understand the latest health headlines, delivers exclusive interviews with celebrities dealing with health issues, debates and investigates health and safety claims, explains the latest viral videos and how you can avoid emergency situations, and serves up celebrity chefs to share the hottest and healthiest recipes and foods.

Why Vitamin D Combats COVID-19 | Amanda Cuocci

As the pandemic continues across the U.S. how can you better position yourself to fight the virus? Our Jessica Stone talks with Health and Wealth Bulletin’s Amanda Cuocci for her thoughts on what can help.

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Vitamin D and COVID-19 || Could Vitamin D Help with COVID-19

Should you take Vitamin C and Vitamin D for Coronavirus | COVID

Should you take Vitamin C and Vitamin D for Coronavirus | COVID-19

⏩ Timestamps, click to skip ahead!
00:00 - Introduction
00:38 - Does Colder Temperatures make you more prone to getting COVID?
02:52 - Why COVID are more likely to cause infections in winter?
03:20 - Vitamin D and COVID
07:20 - Vitamin C and COVID
09:47 - Zinc and COVID

This is the Vitamin D that I take:


Coronavirus | COVID-19 YouTube Video Playlist:


Does colder temperature make you more prone to getting a cold Or COVID-19?
Most health experts agree that when it’s cold, people spend more time indoors and in close contact with other people, and this likely increases the spread of germs.
Also, experts believe that our immune system may be more active when our body is warmer, as in during the summer months.

Back in 2007, there was this study…


In this one particular study looking at the spread of the influenza virus, they put guinea pigs together in a chamber and carried out different environmental experiments on them. They found that low relative humidities of 20%–35% were most favorable for infection, while the transmission was completely blocked at high humidity of 80%.
They also found that when guinea pigs were kept at 5 °C, transmission occurred with greater frequency than at 20 °C, while at 30 °C, no transmission was detected.
The authors concluded that low relative humidities produced by indoor heating and cold
temperatures favored the spread of the influenza virus.

I also want to add, that cold weather, by itself, can cause a runny nose without necessarily
having a cold, and this allows for the virus so be carried in those secretions, which probably facilitates transmission.
40% of common colds are caused by rhinoviruses. The second most common cause of cold is the coronavirus, the normal one, not this novel coronavirus, aka SARS-CoV-2.
Its been shown that the rhinovirus reproduces more quickly at cooler temperatures means you might catch a cold more quickly if you’re chilly.

And this probably applies to the coronavirus as well.

It's likely that with the combination of all of these 5 factors, meaning, cooler temp, lower humidity, people staying indoors more often in winter months, cold weather causing runny noses and our immune system is more active when it's warmer, these combinations of factors likely explain why colds, flu,, and COVID-19 are more likely to cause infections in the winter months.
But there is likely a 6th factor as well. And that is vitamin D. Our bodies don’t normally make vitamin D unless we get sunlight. In the winter months, for most of us in this world, we don’t get enough sunlight to make enough vitamin D. Unless you live in a warm climate, then maybe you are the exception. So if you aren’t getting enough sunlight in the winter months, that means you have to get enough vitamin D in your diet. And if you don’t do that, you will have low vitamin D levels. Vitamin D helps regulate or Calcium levels and is important for bone and muscle health. It also plays a role in regulating our immune system, but its exact role is not known.

Why is this important when it comes to the common cold, flu, and perhaps with this novel the coronavirus that’s causing COVID-19? Well, vitamin D doesn’t affect these viruses themselves. Instead, it affects our immune systems.

So what is my recommendation for taking Vitamin D?
The best thing to do is check with your doctor to see if you might have low vitamin D, and if it is low, you’ll def need to get more vitamin D, especially during the winter months.

Vitamin C is a water-soluble vitamin that is vital to the function of white blood cells that help to fight infections, and overall immune system health. Vitamin C is also important for iron absorption, and being deficient in iron can make you more vulnerable to infections in general.
The normal, recommended daily intake of vitamin C for adults from the diet and/or supplements is 75 to 120 mg. You can get about 80 to 90 mg from a cup of orange juice or sliced orange, or even more from kiwi fruit, or a cup of sweet peppers.

Zinc has become one of the most popular suggestions for reducing symptoms of coronavirus.
Some studies showed that zinc reduces the duration of a cold by half, while others showed no effect. Another study found that the type of zinc taken determined the result—zinc gluconate lozenges that provided 13.3 milligrams (mg) of zinc lessened the duration of colds, but zinc acetate lozenges that provided 5 mg or 11.5 mg of zinc did not.

Note: Please watch the whole video to get the proper details, for the character limitation of the youtube description, I couldn't provide the whole details, so I suggest you, watch the whole video.

Dr. Mike Hansen, MD
Internal Medicine | Pulmonary Disease | Critical Care Medicine

Could Vitamin D Help Protect You From The Virus? | This Morning

As the forecast turns towards scorching sunshine, new reports this week have suggested a link between vitamin D deficiency and the severity of the Coronavirus. Dr Chris separates fact from fiction when it comes to this important vitamin, and gives his advice on how to make sure you’re getting the right amount.
Broadcast on 20/05/20
Subscribe now for more!

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Vitamin D in the times of Covid 19

Understand the nuances of vitamin D and its role in COVID 19.
Dr. Anurag Bajpai, MD, FRACP, SCE, Pediatric Endocrinologist,
Depura Talkies, Sanofi Aventis Webinar
MedEClasses Online Course in Pediatric Endocrinology

Does Vitamin D help with Immunity?

Hopefully YT does not take this video down, as its all based on medical studies. If they keep doing this, I will have to upload my videos to a different website.

The Vitamin D supplement that I take:


So what does not having enough vitamin D have to do with COVID? And IF insufficient vitamin D levels CAUSE more severe disease, why is that? Well, I have to first clarify that it's not proven that insufficient levels of vitamin D lead to worse outcomes. But while it hasn’t been proven, it also certainly hasn’t been disproven. And there is more and more compelling evidence suggesting that lower levels lead to worse outcomes. And there’s no question that vitamin D plays an important role in our immune system. More and more studies are coming out that are sorting out its exact role in this capacity. But the link between poor vitamin D status and risk of certain infections remains cloudy. Back in 2017, there was a meta-analysis study that consisted of 25 different randomized trials with about 11,000 patients in total, evaluating the incidence of acute respiratory infection.

Vitamin D supplementation reduced the percentage of patients experiencing an acute respiratory tract infection. The incidence of URTI in the vitamin D group was 40.3%, compared to 42.2% in the placebo group. In a subgroup analysis, vitamin D supplementation was most effective in patients with vitamin D levels less than 10 ng/mL and in those treated with daily or weekly smaller doses, as opposed to a huge single dose. The takeaway from this meta-analysis study is that, being vitamin d deficient probably makes people more prone to getting upper respiratory infections, and that they should take supplemental vitamin D. But people who have low levels should be taking supplemental vitamin D regardless. Vitamin D has major effects on nearly all cells of our immune system, including dendritic cells, macrophages, and T and B lymphocytes. All of these immune cells have a receptor that binds to vitamin D, called vitamin D receptor, or VDR.

Here are some questions we still need answers to:
1) what level of vitamin D is adequate to protect against, or minimize the impact, of COVID?
2) What level of vitamin D is considered too high
3) should more and more people get their vitamin D levels checked, especially during this pandemic, when less and less people are physically going to the doctor?
4) should people just supplement themselves? If so, how much?

These are all tough questions to answer, especially because we won’t have the results of RCT for vitamin D anytime soon. Given the fact that low dose vitamin D is pretty darn safe, it seems quite reasonable for people to take a low dose supplement, especially if they think they might not be getting enough from sunlight or their diet. Of course, ideally, you want to have a discussion with your doctor if possible.

A common question is, How much Vitamin D should I take a day?
Personally, I take 1,000 IU per day. I know that I’m not going to run anywhere near toxic levels of vitamin D with that dose, while at the same time, I know that I won’t be vitamin D deficient.

Dr. Mike Hansen, MD
Internal Medicine | Pulmonary Disease | Critical Care Medicine
Website:
Instagram Account:

#coronavirus #covid19 #covid_19

Coronavirus Epidemic Update 30: More Global COVID-19 Outbreaks, Vitamin D May Aid Prevention

Coronavirus (COVID-19) Update 30 with pulmonologist Dr. Seheult of

Topics include a variety of growing international coronavirus epidemics including Australia, Norway, Iceland, Iran, Italy, Poland, India, Belgium, South Korea, Canada, and the United States (Los Angeles). Dr. Seheult also discusses compelling evidence about the possible role of Vitamin D (in proper dosage) in fighting acute respiratory infections like COVID-19.

PLEASE NOTE: This video was recorded on March 4, 2020. Our more recent COVID-19 updates can be accessed free at our website or here on YouTube:

We've produced each COVID-19 video with the best information we could access at the time of recording. Naturally, some videos will contain information that has become outdated or replaced by better information or research.

That said, we believe each video contains concepts that have enduring value and reviewing how the response to COVID-19 has progressed over time may be of interest to you as well.


Previous videos from this series:

- Coronavirus Epidemic Update 29: Testing problems, mutations, COVID-19 in Washington & Iran:

- Coronavirus Epidemic Update 28: Practical Prevention Strategies, Patient Age vs. Case Fatality Rate:

- Coronavirus Epidemic Update 27: Testing accuracy for COVID-19 (CT Scan vs. RT-PCR), California Cases:

- Coronavirus Epidemic Update 26: Treatment Updates, Stock Markets, Germany & San Francisco, Pandemic?

- Coronavirus Epidemic Update 25: Vaccine Developments, Italy's Response, and Mortality Rate Trends:

- Coronavirus Epidemic Update 24: Infections in Italy, Transmissibility, COVID-19 Symptoms:

- Coronavirus Epidemic Update 23: Infections in Kids & Pregnancy, South Korea, Spillover From Bats:

- Coronavirus Epidemic Update 22: Spread Without Symptoms, Cruise Quarantine, Asymptomatic Testing:

- Coronavirus Epidemic Update 21: Antibodies, Case Fatality, Clinical Recommendations, 2nd Infections?:

- Coronavirus Epidemic Update 20: Misinformation Spread, Infection Severity, Cruise Ship, Origins:

- Coronavirus Epidemic Update 19: Treatment and Medication Clinical Trials:

- Coronavirus Epidemic Update 18: Cellphone Tracking, Increase in Hospitalizations, More Sleep Tips:

- Coronavirus Epidemic Update 17: Spike in Confirmed Cases, Fighting Infections with Sleep (COVID-19):

- Coronavirus Epidemic Update 16: Strengthening Your Immune Response to Viral Infections (COVID-19):

- Coronavirus Epidemic Update 15: Underreporting, Prevention, 24 Day Incubation? (COVID19)

- Coronavirus Epidemic Update 14: Hospital spread of infection, WHO allowed in China, N-95 masks:

- Coronavirus Epidemic Update 13: Li Wenliang, nCoV vs Influenza, Dip in Daily Cases, Spread to Canada:

- Coronavirus Epidemic Update 12: Unsupported Theories, Pneumonia, ACE2 & nCoV:

- Coronavirus Epidemic Update 11: Antiviral Drugs, Treatment Trials for nCoV (Remdesivir, Chloroquine):

- Coronavirus Epidemic Update 10: New Studies, Transmission, Spread from Wuhan, Prevention (2019-nCoV):

- Coronavirus Epidemic Update 9: Fecal-Oral Transmission, Recovery vs Death Rate:

- How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment:

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LINKS for references from this video:

















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Speaker: Roger Seheult, MD
Produced by Kyle Allred, PA

Note: MedCram medical videos are for medical education and exam preparation, and not intended to replace recommendations by your doctor.
#Coronavirus #COVID19 #SARSCoV2

Vitamin D deficiency and Covid-19: is there a relationship?

Prof. Andrea Giustina, Full Professor of Endocrinology, The Vita-Salute San Raffaele University, Milan, President of the European Society of Endocrinology.

Vitamin D, First clinical trial

Please share this video around, this message needs to get out there, thank you, John


About 42% of the US population is vitamin D deficient

82% in black people

70% in Hispanics

Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results, (JAMA Open, 3rd September, Chicago)



Cohort study of 489

Patients who had a vitamin D level measured in the year before COVID-19
testing

Relative risk of testing positive for COVID-19 was 1.77 times

First clinical trial on vitamin D and COVID

Therapy versus best Available Therapy on Intensive Care Unit Admission and Mortality Among Patients Hospitalized for COVID-19: A Pilot Randomized Clinical study (Spain, Journal of steroid biochemistry and molecular biology)



Objective

Vitamin D decreases Acute Respiratory Distress Syndrome

Effect of calcifediol treatment

Calcifediol can rapidly increase serum 25OHD concentration

25-hydroxyvitamin D

Intensive Care Unit Admission and Mortality

Spanish patients hospitalized for COVID-19.

Design

Parallel pilot, randomized, double-masked clinical trial

Setting

Reina Sofia University Hospital, Córdoba, Spain

Participants

76 consecutive patients hospitalized with COVID-19 infection

Clinical picture of acute respiratory infection

Confirmed by a radiographic pattern of viral pneumonia

Positive SARS-CoV-2 PCR

Procedures

All hospitalized patients received as best available therapy

Hydroxychloroquine and azithromycin

Allocated at a 2 calcifediol:1

Oral calcifediol (0.532 mg), or not

Oral calcifediol (0.266 mg) on day 3 and 7

Then weekly until discharge

End points, ICU admission and deaths.

Results

50 patients treated with calcifediol

One required admission to the ICU (2%),

Of 26 untreated patients, 13 required admission (50%)

p  less than 0.001

Of the patients treated with calcifediol, none died, and all were discharged, without complications

Of the patients not treated, 2 died

Conclusion

Calcifediol seems to be able to reduce severity of the disease

Larger trials with groups properly matched will be required to show a definitive answer

Rationale, activation of the vitamin D receptor (VDR) signalling pathway

Reduced ARDS

Cytokine/chemokine storm

Regulating the renin angiotensin system

Modulating neutrophil activity

Maintaining the integrity of the pulmonary epithelial barrier

Stimulating epithelial repair

Tapering down the increased coagulability


Ventilate

Don't abdicate
Dilute that virus
So you stay great
Ventilate
Don't complicate,
Complain or whine
You'll acclimate
Contemplate
When you congregate
Does the air here circulate
Instigate, Nominate
Educate, Motivate
I hope this message will resonate
That when we populate
Instead of isolate
Ventilate
Don't abdicate
Dilute that virus
So you stay great

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