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Importance of Vitamin D to fight against Corona

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Vitamin D and COVID 19: The Evidence for Prevention and Treatment of Coronavirus (SARS CoV 2)

Professor Roger Seheult, MD explains the important role Vitamin D may have in the prevention and treatment of COVID-19. Dr. Seheult illustrates how Vitamin D works, summarizes the best available data and clinical trials on vitamin D, and discusses vitamin D dosage recommendations.

Roger Seheult, MD is the co-founder and lead professor at
He is an Associate Professor at the University of California, Riverside School of Medicine and Assistant Prof. at Loma Linda University School of Medicine
Dr. Seheult is Quadruple Board Certified: Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine

Interviewer: Kyle Allred, Producer and Co-Founder of MedCram.com

REFERENCES:

The National Human Activity Pattern Survey (NHAPS)... (J. of Exposure A. and Env. Epidem.) |

Aging decreases the capacity of human skin to produce vitamin D3 (The J. of Clin. Invest.) |

Racial differences in the relationship between vitamin D... (Osteoporosis Int.) |

Decreased bioavailability of vitamin D in obesity (The American J of Clin. Nutrition) |

Vitamin D Insufficiency and Deficiency and Mortality from Respiratory Diseases ... (Nutrients) |

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis... (BMJ) |

Randomized trial of vitamin D supplementation to prevent seasonal influenza A... (The American J.of Clin. Nutrition) |

Vitamin D and SARS-CoV-2 infection... (Irish J. of Med. Sci.) |

Factors associated with COVID-19-related death... (Nature) |

Editorial: low population mortality from COVID-19 ... (Alimentary Pharm. & Therap.) |

The role of vitamin D in the prevention of coronavirus ... (Aging Clin. & Exper. Res.) |

25-Hydroxyvitamin D Concentrations Are Lower in Patients with ... SARS-CoV-2 (Nutrients) |

Vitamin D deficiency in COVID-19: Mixing up cause and consequence (Metabolism) |

Low plasma 25(OH) vitamin D level... increased risk of COVID-19... (The FEBS J.) |

The link between vitamin D deficiency and Covid-19... |

SARS-CoV-2 positivity rates... with circulating 25-hydroxyvitamin D levels (PLOS One) |

Vitamin D status and outcomes for... COVID-19 (Post. Med. J.) |

Vitamin D Deficiency and Outcome of COVID-19... (Nutrients) |

“Effect of calcifediol treatment...” (J. of Steroid Bio. Molec. Bio.) |

Vitamin D and survival in COVID-19 patients... (J. of Steroid Bio. Molec. Bio.) |

Effect of Vitamin D3 ... vs Placebo on Hospital Length of Stay...: A Multicenter, Double-blind, RCT |

Short term, high-dose vitamin D... for COVID-19 disease: RCT [SHADE study] (Postgrad. Med. Journal) |

Association of Vitamin D Status... With COVID-19 Test Results (JAMA Network Open) |

Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline (JCEM) |

Vitamin D Fortification of Fluid Milk ... A Review (Nutrients) |

Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients... (Scientific Reports from the Journal Nature) |

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Does Supplemental Vitamin D Help Prevent Covid-19?

Ah, Vitamin D, back again. We’ve made our case on how unnecessary Vitamin D supplements are for outcomes like diabetes, cardiovascular and musculoskeletal health, and overall mortality. But what about its effect on viral infections like Covid-19? Can it reduce symptom severity, or perhaps even reduce your odds of becoming infected in the first place?

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Can vitamin D help fight COVID-19?

Former trauma surgeon Dr. L. Ray Matthews discusses research looking into the potential impact of vitamin D in the fight against the coronavirus.

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Can vitamin D help prevent COVID-19?

Dr. Jen Ashton has the latest information on the potential benefits of vitamin D.
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How Does Vitamin D Help Us Fight COVID?

Dr. David Meltzer from the University of Chicago joins to share about the findings of his recent study, which found that patients who were vitamin D deficient were about 77% more likely to test positive for COVID than patients who weren’t. There are many ways to get vitamin D, including the sun, vitamin D fortified foods, and supplements.

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Vitamin D, Immune System & SARS-CoV-2 (COVID-19) | Mechanism of Vit D Immune Regulation & Overview

Vitamin D, Immune System & SARS-CoV-2 (COVID-19) | Mechanism of Vit D Immune Regulation, Overview of Evidence

In this lesson, I discuss the vitamin D its immune system regulation, specifically with regards to how vitamin D can help protect against respiratory tract infections like SARS-CoV-2 (COVID-19).

1) Brief Introduction to Vitamin D and SARS-CoV-2

2) Vitamin D deficiency and increased risk of infections

3) Vitamin D supplementation and protection against acute respiratory tract infections

4) Vitamin D and Immune System Regulation (including cytokines like IL-6)

5) Vitamin D and SARS-CoV-2 (COVID-19), comorbidities and associations

3) Summary of some Remdesivir data in in-vitro and in-vivo (mice and rhesus monkeys) studies used in treatment of other coronaviruses like SARS-CoV and MERS-CoV

****EXCLAIMER: The content (ex. images) used in this lesson are used in accordance with Fair Use laws and is intended for educational purposes only.****

*DISCLAIMER* Although there has been a meta-analysis showing reduced risk of acute respiratory tract infections with daily/weekly recommended doses of Vitamin D, WE DON’T have enough evidence to say that Vitamin D is protective against SARS-CoV-2 (COVID-19) – WE ONLY HAVE ASSOCIATIONS/CORRELATIONS at this point.

***This video is merely here to PRESENT INFORMATION from the studies quoted in this video - if people have an issue with the data, I would suggest they read over these studies and contact the experimenters/authors****

I hope you find this lesson helpful! If you do, please give this video a thumbs up and consider subscribing to the channel – all of your support is greatly appreciated!
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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*

Could Vitamin D Help Fight COVID-19?

My opinion is that you keep the correct levels of vitamin D in your body. Now a days, due to staying indoors, it is possible that you will develop the deficiency of vitamin D. Get this checked by your doctor and use the correct dose to stay healthy.

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Here are my notes:
Daily 10 microgram or 400 IU/Day

Lippincott’s Biochemistry Review 4th Edition. Page 388
Daily 5 mg of cholecalciferol or 200 IU of Vitamin D.

However, 800 IU/Day is shown to reduce the incidence of osteoporotic fractures.
800 IU/Day recommended by the Institute of Medicine to maintain bone health.

Frank deficiency is when the levels of 25-hydroxycholecalciferol (25OHD) is less than 20 ng/mL (50 mmol/L)


No consensus that the oral vitamin D supplements are helpful

Ergocalciferol from plants is called Vitamin D2
Cholecalciferol from the animal tissue is called Vitamin D3

7 deidro-cholesterol to (UV light) to cholecalciferol (D3) to 25 hydroxylase in liver to 25 OH D to -hydroxycholecalciferol 1-hydroxylase in kidney to 1,25 DiOH D3




Vitamin D Receptors are abbreviated to VDR in the notes. These are cytosolic receptors.


Deficiency of vitamin D makes people more susceptible to respiratory tract infections.
Vitamin D supplement can reduce these infections by 12%
Keep in mind, this is for those who are deficient in this vitamin. If you are not deficient, then it will not make a difference. Because, you are already good.
Evidence is not sufficient to say that vitamin D helps prevent respiratory infections.

2018 Study

People with autoimmune diseases commonly have hypovitaminosis D

What are cathelicidins?


What are beta defensins?



2011 Study


Activation of TLR and PAMPs on macrophages increases the production of 1, alpha hydroxylase and the VDR. This in turn causes more production of cathelicidine and beta defensins 4.

Vitamin D also affects monocytes to reduce production of IL1, IL6, IL8, IL12, and TNF. Regulating the immune response.

Vitamin D acts on the dendritic cells to inhibit/reduce their differentiation and maturation. It reduces their MHCII expression, co-stimulatory molecules like CD40, CD80, CD86, decreased production of IL-12 etc.

2013 Study

Vitamin D improves immune system by helping produce cathelicidine and by helping modulate inflammatory cascade. Especially for the respiratory infections.
It also helps produce NFk-B (nuclear factor kappa light chain for activated B cells.)

(
Notes about the NFkB

Helps with cytokine production and cell survival.
NFk-B factor becomes active when T and B cell receptors become active. Its activation causes the gene expressions that allow T cell development, maturation, and proliferation.
T and B cells have Vitamin D receptors that help them produce NFk-B
)

Continuing the notes from the study:
In pulmonary infections. Lung epithelial cells are able to convert inactive vitamin D to its active form. This active Vitamin D then helps produce cathelicidine. Which helps kill the pathogens.

Vitamin D seems to favor TH2 and TH17 cell activation which is anti-inflammatory profile.
Vitamin D seems to reduce the activation of TH1 cells which are pro inflammatory by their IFN-gamma action.
A deficiency of vitamin D may dysregulate the inflammatory response of the body.

Vitamin B also increases the IkBa. This leads to inhibition of NFkB. This helps reduce the production of IL6 and IL8 by inhibiting the production of NFkB.

Vitamin D might just save you from getting Covid-19

There may be a cheap and effective way to help prevent getting infected with Covid-19 and fighting it if you’ve already been infected. Taha Meli Arvas explains, In Brief.

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#Covid19 #VitaminD #Coronavirus

Vitamin D & COVID-19: Dr. David Meltzer discusses benefits

Dr. David Meltzer of the University of Chicago joins WGN Evening News to discuss how a proper Vitamin D level can help play a role in reducing one's risk to COVID-19.

Vitamin D and COVID 19 | COVID Vitamin D Relationship | Does Vitamin D prevent Coronavirus

Does Vitamin D protect against SARS CoV-2 - A detailed Analysis and what to do?
This Topic and Video was inspired by my dear Elder Brother and Friend Dr Adil Haroon Khan. Who has numerous other ideas on how to deal with the COVID 19 situation.

He is proposing use of Antihistamines, vitamin D 800-2000 units, inhaler (salbutamol & ipratropium) and montelukast for early management of respiratory symptoms in Covid patients.

He is always an inspiration - Ckeck out his video

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Vitamin C, Vitamin D and COVID - Prevention of COVID

Vitamin C, Vitamin D and COVID - Prevention of COVID

Does colder temperature make you more prone to getting a cold Or COVID?
Most health experts agree that people spend more time indoors and in close contact with other people when it’s cold, which likely increases germs spread.
Also, experts believe that our immune system may be more active when our body is warmer, as in during the summer months.

⏩ Timestamps, click to skip ahead!
00:00 - Introduction
00:38 - Do Colder Temperatures make you more prone to getting COVID?
02:52 - Why COVID are more likely to cause infections in winter?
03:20 - Vitamin D and COVID
07:20 - Vitamin C and COVID
09:47 - Zinc and COVID

This is the Vitamin D that I take:


COVID Update Today by Doctor Mike Hansen (YouTube Video Playlist)


Back in 2007, there was this study…

- In this one particular study looking at the spread of the influenza virus, they put guinea pigs together in a chamber and carried out different environmental experiments on them. They found that low relative humidities of 20%–35% were most favorable for infection, while the transmission was completely blocked at high humidity of 80%.
They also found that when guinea pigs were kept at 5 °C, transmission occurred with greater frequency than at 20 °C, while at 30 °C, no transmission was detected.
The authors concluded that low relative humidities produced by indoor heating and cold
temperatures favored the spread of the influenza virus.

I also want to add that cold weather, by itself, can cause a runny nose without necessarily
having a cold allows for the virus to be carried in those secretions, which probably facilitates transmission.
40% of common colds are caused by rhinoviruses. The second most common cause of cold is the coronavirus, the normal one, not this novel coronavirus.
Its been shown that the rhinovirus reproduces more quickly at cooler temperatures means you might catch a cold more quickly if you’re chilly.

And this probably applies to the coronavirus as well.

It's likely that with the combination of all of these 5 factors, meaning cooler temp, lower humidity, people staying indoors more often in winter months, cold weather causing runny noses, and our immune system is more active when it's warmer, these combinations of factors likely explain why colds, flu, and COVID are more likely to cause infections in the winter months.
But there is likely a 6th factor as well. And that is vitamin D. Our bodies don’t normally make vitamin D unless we get sunlight. In the winter months, for most of us in this world, we don’t get enough sunlight to make enough vitamin D. Unless you live in a warm, maybe you are the exception. So if you aren’t getting enough sunlight in the winter months, that means you have to get enough vitamin D in your diet. And if you don’t do that, you will have low vitamin D levels. Vitamin D helps regulate or Calcium levels and is important for bone and muscle health. It also plays a role in regulating our immune system, but its exact role is not known.

Why is this important for the common cold, flu, and perhaps with this novel, the coronavirus that’s causing COVID? Well, vitamin D doesn’t affect these viruses themselves. Instead, it affects our immune systems.

So what is my recommendation for taking Vitamin D?
The best thing to do is check with your doctor to see if you might have low vitamin D, and if it is low, you’ll def need to get more vitamin D, especially during the winter months.

Vitamin C is a water-soluble vitamin. It is vital to white blood cells that help to fight infections and overall immune system health. Vitamin C is also important for iron absorption, and being deficient in iron can make you more vulnerable to infections in general.
The normal, recommended daily intake of vitamin C for adults from the diet and/or supplements is 75 to 120 mg. You can get about 80 to 90 mg from a cup of orange juice or sliced orange, or even more from kiwi fruit or a cup of sweet peppers.

Zinc has become one of the most popular suggestions for reducing symptoms of COVID.
Some studies showed that zinc reduces the duration of a cold by half, while others showed no effect. Another study found that the type of zinc taken determined the result—zinc gluconate lozenges that provided 13.3 milligrams (mg) of zinc lessened the duration of colds, but zinc acetate lozenges that provided 5 mg or 11.5 mg of zinc did not.

Note: Please watch the whole video to get the proper details. For the youtube description character limitations, I couldn't provide the whole details, so I suggest watching the whole video.

Doctor Mike Hansen, MDInternal Medicine | Pulmonary Disease | Critical Care MedicineWebsite: Account: #covid19 #coronavirus

Does VITAMIN D Protect Against COVID-19? | Doctor ER

Does VITAMIN D Protect Against COVID-19? | Doctor ER. Vitamin D and COVID 19: Board-Certified Emergency Medicine Physician, Dr. Jordan Wagner explains the latest COVID news and the important role vitamin D may have in the prevention and treatment of coronavirus. What is the link between COVID-19 and vitamin D? Vitamin D deficiency has been associated with rickets, however, 120 health, science, and medical experts from the United States and Europe say there is scientific evidence that vitamin D reduces infections, hospitalizations, and deaths during the COVID-19 pandemic. Can I take any vitamins or supplements to prevent COVID-19? Is vitamin D important for the immune system? What is the best way to reduce the spread of COVID-19? The role of vitamin D in preventing viral infections, including COVID-19, is gaining attention as more studies are released. A new study that looked at 216 people with COVID-19 found that 80% did not have adequate levels of vitamin D (vitamin D3) in their blood. Doctor Jordan Wagner is always sharing his experience coping with the COVID-19 pandemic and what he's learned first hand treating COVID-19 patients. If you have any medical questions, COVID-19 questions, or even a funny quarantine vlog, send it my way! Thanks so much for watching. Stay healthy, my friends!

OTHER VIDEOS ABOUT VITAMIN D AND COVID-19:

MedCram - Medical Lectures Explained CLEARLY - Vitamin D and COVID 19: The Evidence for Prevention and Treatment of Coronavirus (SARS CoV 2)


Doctor Mike Hansen - COVID 19: Should you take Vitamin C and Vitamin D to fight COVID


Doctor Mike - Doctor Reacts To Simpsons Medical Scenes


The Daily Show with Trevor Noah - The Best of Michael Kosta in the Field | The Daily Social Distancing Show


TODAY - Officials Fear ‘Surge’ In COVID-19 Cases After Christmas | TODAY


Doctor Mike Hansen - Vitamin D for SEVERE Covid 19? (And other final 2020 Thoughts)


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Coronavirus Disease 2019 (COVID-19) | CDC


Coronavirus disease (COVID-19) - World Health Organization (WHO)


Coronavirus Disease 2019 (COVID-19) | coronavirus.gov


Coronavirus (COVID-19) Response | FEMA.gov


Coronavirus Disease 2019 (COVID-19) | FDA


Vitamin D and SARS-CoV-2 infection—evolution of evidence supporting clinical practice and policy development | Irish Journal of Medical Science


The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality | Aging Clinical & Experimental Research


25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2 |
Nutrients


The link between vitamin D deficiency and Covid-19 in a large population


Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study) | Postgraduate Medical Journal


** WARNING** If you feel like you are actually experiencing a real-life medical emergency, immediately stop watching and call 9-11 or contact a medical professional. The information in this video is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace an appointment with your own personal doctor/mental health professional!

Explained: Does Vitamin D protect against coronavirus disease?

As Covid-19 cases surge across the world, data from 20 European countries showed that nations with low levels of Vitamin D had higher Covid related death rates. So how exactly does Vitamin D aid in the battle against Covid and is it enough to protect one from being infected by coronavirus? Watch this video to find out.

Vitamin D and COVID-19 || Could Vitamin D Help with COVID-19

Does Vitamin D help with Immunity? || Vitamin D and Covid 19

Does Vitamin D help with Immunity? || Vitamin D and Covid 19
#covid #covid19 #coronavirus

COVID Update Today by Doctor Mike Hansen (YouTube Video Playlist)


Hopefully, YT does not take this video down, as it's all based on medical studies. If they keep doing this, I will have to upload my videos to a different website.

The Vitamin D supplement that I take:


Mentioned Video:
Vitamin D3 (Cholecalciferol) and Vitamin D2 (Ergocalciferol) and Calcitriol
Video Link:

So what does not having enough vitamin D have to do with COVID 19? And IF insufficient vitamin D levels CAUSE more severe disease, why is that? Well, I have to first clarify that it's not proven that insufficient vitamin D levels lead to worse outcomes. But while it hasn’t been proven, it also certainly hasn’t been disproven. And there is more and more compelling evidence suggesting that lower levels lead to worse outcomes. And there’s no question that vitamin D plays an important role in our immune system. More and more studies are coming out that are sorting out its exact role in this capacity. But the link between poor vitamin D status and risk of certain infections remains cloudy. In 2017, a meta-analysis study consisted of 25 different randomized trials with about 11,000 patients in total, evaluating the incidence of acute respiratory infection.

Vitamin D supplementation reduced the percentage of patients experiencing an acute respiratory tract infection. The incidence of URTI in the vitamin D group was 40.3%, compared to 42.2% in the placebo group. In a subgroup analysis, vitamin D supplementation was most effective in patients with vitamin D levels less than 10 ng/mL and those treated daily or weekly smaller doses instead of a huge single dose. The takeaway from this meta-analysis study is that being vitamin d deficient probably makes people more prone to getting upper respiratory infections and should take supplemental vitamin D. But people who have low levels should be taking supplemental vitamin D regardless. Vitamin D has major effects on nearly all our immune system cells, including dendritic cells, macrophages, and T and B lymphocytes. These immune cells have a receptor that binds to vitamin D, called the vitamin D receptor, or VDR.

Here are some questions we still need answers to:
1) what level of vitamin D is adequate to protect against or minimize the impact of COVID 19?
2) What level of vitamin D is considered too high
3) should more and more people get their vitamin D levels checked, especially during this pandemic, when fewer and fewer people are physically going to the doctor?
4) should people just supplement themselves? If so, how much?

These are all tough questions to answer, especially because we won’t have RCT results for vitamin D anytime soon. Given that low dose, vitamin D is pretty darn safe, it seems quite reasonable for people to take a low dose supplement, especially if they think they might not be getting enough from sunlight or their diet. Of course, ideally, you want to have a discussion with your doctor if possible.

A common question is, How much Vitamin D should I take a day?
Personally, I take 1,000 IU per day. I know that I’m not going to run anywhere near toxic levels of vitamin D with that dose, while at the same time, I know that I won’t be vitamin D deficient.

Doctor Mike Hansen, MD
Internal Medicine | Pulmonary Disease | Critical Care Medicine
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Could Vitamin D Help Protect You From The Virus? | This Morning

As the forecast turns towards scorching sunshine, new reports this week have suggested a link between vitamin D deficiency and the severity of the Coronavirus. Dr Chris separates fact from fiction when it comes to this important vitamin, and gives his advice on how to make sure you’re getting the right amount.
Broadcast on 20/05/20
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Coronavirus Pandemic Update 97: Vitamin D & COVID-19 Immunity, The Endothelium, & Deficiencies

The role of vitamin D in preventing viral infections, including COVID-19, is gaining attention as more studies are released. In this video, Dr. Seheult of discusses a recent vitamin D review article published in the peer-reviewed journal Nutrients which has compelling implications for COVID-19 and overall vascular and endothelial health. (This video was recorded July 16, 2020).

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- Coronavirus Pandemic Update 83: High Fructose, Vitamin D, & Oxidative Stress in COVID-19
- Coronavirus Pandemic Update 82: Racial Disparities with COVID-19 & Vitamin D
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#COVID19 #SARSCoV2 #FOAMed

New Study - Vitamin D High Dose and COVID-19

New Study - Vitamin D High Dose and COVID-19

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2% of the patients taking high dose calcifediol were admitted to ICU.
50% of the patients not taking calcifediol were admitted to ICU.

Effect of calcifidiol (25(OH)D) on severity and disease progress of COVID-19


Effect of vitamin D receptor activation


Vitamin D deficiency in the US population


Obesity and vitamin d deficiency. A study of their relationship


What is cholecalciferol?


What is calcifediol?


Active Vitamin D synthesis pathway


Should you always take calcium and vitamin K2 with vitamin D?


Cathelicidins

Vitamins to Prevent COVID???

Dr. Christy looks at the data on several vitamins, minerals and supplements and provides recommendations on all.

REFERENCES:
EVMS/Dr. Marik COVID Protocols:




VITAMIN C:


1. Douglas RM, Hemilä H, Chalker E, Treacy B. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev 2007;(3):CD000980. [PubMed abstract]
Vitamin D:
BMJ Article:



Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 2017;356:i6583.
Zhou YF, Luo BA, Qin LL. The association between vitamin D deficiency and community-acquired pneumonia: A meta-analysis of observational studies. Medicine (Baltimore). 2019;98:e17252.


ZINC:






B VITAMINS:




MELATONIN:

Reiter RJ, Abreu-Gonzalez P, Marik PE, Dominguez-Rodriguez A. Therapeutic algorithm for use of melatonin in patients with COVID-19. Front Med 2020; 7:226.

कोरोना पर असरदार Vitamin D | Importance of Vitamin D to fight against Corona | #CORONA

Importance of Vitamin D to fight against Corona

As the Corona pandemic goes on increasing it is important for us to take care of ourselves and boost our immune system.
One such important aspect to have a good immune system is the presence of Vitamin D in our body.

Dr. Amol Annadate has discussed the importance of Vitamin D for increasing immunity and also ways by which we can obtain this important Vitamin in the right proportion.

00:30 How does vitamin D help in fighting Corona?
1:40 What part of the body or process does Vitamin D help in a human body?and what all disease it can help against?
2:15 How should we take Vitamin D naturally?
3:25 How much Vitamin D should we take and what tablet to take?
4:32 When should we eat the tablet?

#StayHomeStaySafe #coronavirus #latestnews

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Importance of Vitamin D in small children.

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