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Lung immune cells as drivers of influenza outcomes

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Cytokine Storm Syndrome in the Lungs

What happens when the body’s own immune system mounts an uncontrolled response to infection? Watch as we explore this phenomenon known as cytokine storm syndrome with a focus on how it occurs in the context of viral infections, like coronaviruses, in the lungs.
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Vaccines and Related Biological Products Advisory Committee – 9/17/2021

Join us for a Vaccines and Related Biological Products Advisory Committee meeting to discuss Pfizer-BioNTech’s supplemental Biologics License Application for administration of a third dose, or “booster” dose, of the COVID-19 vaccine, Comirnaty, in individuals 16 years of age and older.

Watch live captions here:
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How COVID-19 Turns Your Immune System Against You

Learn more about the Yale School of Medicine's response to COVID-19, visit:

Dr. Akiko Iwasaki is an Investigator of the HHMI and Waldemar Von Zedtwitz Professor of Department of Immunobiology, and of Department of Molecular Cellular and Developmental Biology. Her laboratory is actively engaged in both surveillance and research efforts to understand viral prevalence and in studying the immune response that leads to protective versus pathologic consequences of COVID-19.

Faculty across Yale, including at the School of Medicine, School of Nursing, School of Public Health, School of Engineering & Applied Science and Faculty of Arts and Sciences are actively engaged in research, innovation, and clinical efforts to combat COVID-19.

Attribution:


flickr.com/photos/navymedicine
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Vitamin D and COVID 19: The Evidence for Prevention and Treatment of Coronavirus (SARS CoV 2)

Professor Roger Seheult, MD explains the important role Vitamin D may have in the prevention and treatment of COVID-19. Dr. Seheult is the lead professor at
Dr. Seheult illustrates how Vitamin D works, summarizes the best available data and clinical trials on vitamin D, and discusses vitamin D dosage recommendations.

Roger Seheult, MD is Co-Founder of MedCram and an Associate Professor at the University of California, Riverside School of Medicine and Assistant Prof. at Loma Linda University School of Medicine. He is Quadruple Board Certified: Internal Medicine, Pulmonary Disease, Critical Care, & Sleep Medicine

Interviewer: Kyle Allred, Producer & Co-Founder of MedCram.com

REFERENCES:

The National Human Activity Pattern Survey (NHAPS)... (J. of Exposure A. and Env. Epidem.) |

Aging decreases the capacity of human skin to produce vitamin D3 (The J. of Clin. Invest.) |

Racial differences in the relationship between vitamin D... (Osteoporosis Int.) |

Decreased bioavailability of vitamin D in obesity (The American J of Clin. Nutrition) |

Vitamin D Insufficiency and Deficiency and Mortality from Respiratory Diseases ... (Nutrients) |

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis... (BMJ) |

Randomized trial of vitamin D supplementation to prevent seasonal influenza A... (The American J.of Clin. Nutrition) |

Vitamin D and SARS-CoV-2 infection... (Irish J. of Med. Sci.) |

Factors associated with COVID-19-related death... (Nature) |

Editorial: low population mortality from COVID-19 ... (Alimentary Pharm. & Therap.) |

The role of vitamin D in the prevention of coronavirus ... (Aging Clin. & Exper. Res.) |

25-Hydroxyvitamin D Concentrations Are Lower in Patients with ... SARS-CoV-2 (Nutrients) |

Vitamin D deficiency in COVID-19: Mixing up cause and consequence (Metabolism) |

Low plasma 25(OH) vitamin D level... increased risk of COVID-19... (The FEBS J.) |

The link between vitamin D deficiency and Covid-19... |

SARS-CoV-2 positivity rates... with circulating 25-hydroxyvitamin D levels (PLOS One) |

Vitamin D status and outcomes for... COVID-19 (Post. Med. J.) |

Vitamin D Deficiency and Outcome of COVID-19... (Nutrients) |

“Effect of calcifediol treatment...” (J. of Steroid Bio. Molec. Bio.) |

Vitamin D and survival in COVID-19 patients... (J. of Steroid Bio. Molec. Bio.) |

Effect of Vitamin D3 ... vs Placebo on Hospital Length of Stay...: A Multicenter, Double-blind, RCT |

Short term, high-dose vitamin D... for COVID-19 disease: RCT [SHADE study] (Postgrad. Med. Journal) |

Association of Vitamin D Status... With COVID-19 Test Results (JAMA Network Open) |

Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline (JCEM) |

Vitamin D Fortification of Fluid Milk ... A Review (Nutrients) |

Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients... (Scientific Reports from the Journal Nature) |

MEDCRAM.COM

Visit us for videos on over 60 medical topics and CME / CEs for clinicians:
All coronavirus updates are at MedCram.com (COVID-19 developments, cholecalciferol, vitamin d benefits, vitamin D biochemistry, vitamin B12 etc.)

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MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
#COVID19 #SARSCoV2 #VitaminD
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SBI.ImunoTalks “Innate immune response in COVID-19”

SBI.ImunoTalks “Innate immune response in COVID-19”, com os pesquisadores Amanda Jamieson (Brown University – USA), Dario Zamboni (FMRP/USP - Brazil) e Cristina Cardoso (SBI).

- Role of the lung epithelium in directing COVID-19 - induced pathology: Amanda Jamieson (Brown University – USA);

- Inflammasome activation in COVID-19 patients: Dario Zamboni (FMRP/USP - Brazil)

Chair: Cristina Cardoso (SBI)

Transmissão em: 24 de setembro de 2020.

First Responders: SARS-CoV-2 & the Immune System

Angela Rasmussen and Ya-Chi Ho explore the positive and negative aspects of the host immune response to SARS-CoV-2 infection and discuss how this knowledge influences therapeutic benefits.

The immune system fights SARS-CoV-2 infection, but it also causes serious clinical symptoms when it rages out of control. In this webinar, Angela Rasmussen and Ya-Chi Ho will discuss how the immune system reacts to SARS-CoV-2, whether these responses are beneficial or deleterious, and the mechanisms by which immune responses determine COVID-19 severity and patient outcomes.

Topics to be covered

- The nature of the host response to SARS-CoV-2
- Understanding adaptive immune responses to SARS-CoV-2 using high-dimensional single-cell profiling

COVID-19 and The Immune Response with Dr. Donna Farber

Renowned researcher Donna L. Farber, PhD of the Columbia Center for Translational Immunology brings us up-to-date on current knowledge about the virus and shares her insights on what this means for ongoing management.

Webinar recorded on January 20, 2021.

Paul Thomas - Influenza Webinar Series - September 2018

Dr. Paul Thomas (St. Jude Children's Research Hospital) gives a talk on host immune and genetic factors which regulate outcomes in influenza vaccination, hosted by the Human Vaccines Project and Vanderbilt University Medical Center.

Kiran Krishnan -- The Microbiome’s Control of Immune Function

The world has lived through an unprecedented time with the pandemic spread of Covid-19. In an effort to decrease our susceptibility to other harmful viral infections, this is an opportunity to collectively educate your patients (the public) on the power of preventative healthcare and to get a better understanding of our natural defenses. The microbiome and the immune system are inextricably connected and the immune system would cease to function without the microbiome. The microbiome acts as the “Neighborhood Watch” for the immune system allowing for effective surveillance of a mucosal system that is over 3000 sq ft in surface area and inhabited by over 40 trillion microbes. This presentation will provide a review on the components of the immune system, the kinetics of our immune response and the critical support and check-points managed by the microbiome. One of our most powerful tools in fighting invading pathogens is having a healthy microbiome and this talk will illustrate what exactly that means.

From the 2021 Soil & Nutrition Conference -
Hosted by the Bionutrient Food Association -

Genomic Response to the Social Environment: Implications for Health Outcomes

The goal of the Workshop is to build the knowledge of the genomic mechanisms underlying the contribution of the social environment to health outcomes and to exchange ideas on advancing a social genomics research strategy that will further elucidate gene-environment influences on the burden of disease and inform future intervention approaches.
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Targeting host metabolism in respiratory viral infections

Presented By: Heather Smallwood, PhD

Speaker Biography: Heather is an Assistant Professor in the Department of Pediatrics and the Institute for the Study of Host-Pathogen Systems at the University of Tennessee Health Science Center. She is a cell biologist trained in biochemistry and infectious disease. She received her doctorate of philosophy in Biochemistry and Applied Environmental Toxicology through the University of Washington-Pacific Northwest National Laboratory Distinguished Graduate Research Program.

Webinar: Targeting host metabolism in respiratory viral infections

Webinar Abstract: Targeting host metabolism in respiratory viral infections: can we exploit viral metabolic reprogramming with drug interventions to ameliorate disease symptoms and severity or even prevent the virus from taking hold?

COVID 19 Vaccine Deep Dive: Safety, Immunity, RNA Production, (Pfizer Vaccine / Moderna Vaccine)

Professor Shane Crotty, PhD joins MedCram to answer a series of COVID vaccine questions including what are the chances of long-term side effects? How safe is RNA vaccine (i.e. Pfizer / BioNTech and Moderna Vaccines) technology? How long does mRNA from a vaccine stay in our cells? What else goes in vaccines? How long does immunity last? Why are T-Cells so important? Why does Pfizer's vaccine need to stay SO cold?

Shane Crotty, PhD is a Professor at the La Jolla Institute for Immunology, Center for Infectious Disease and Vaccine Research, Crotty Lab. Professor Crotty also has an academic appointment with the University of California San Diego. See his full bio here:
Professor Crotty on Twitter:

Interviewer: Kyle Allred, Physician Assistant, Producer and Co-Founder of MedCram.com

See our new interview with Prof. Crotty on how virus mutations (UK variant and S. African variant) may be impacting COVID-19 transmission and vaccine efficacy.

Research referenced in this video from Prof. Crotty and his team was published Jan. 6, 2021, in the prestigious Journal Science:

New York Times article highlighting Prof. Shane Crotty's research:

00:00 Introducing Prof. Shane Crotty's Research
0:35 How long does COVID-19 immune memory last?
0:57 The three primary aspects of immune memory: antibodies, killer T cells, and helper T cells
2:25 The anatomy (protein makeup) of SARS-CoV-2
3:02 Why is spike protein the primary target?
5:17 Could a mutation allow SARS-CoV-2 to infect without spike protein?
7:02 Utilizing lipid nanoparticles to deliver mRNA and the role of RNA normally
9:52 What human cells does an RNA vaccine go into?
10:36 How long does mRNA from a vaccine stay in human cells?
11:44 What else goes in vaccines besides mRNA and lipid nanoparticles? Any preservatives or adjuvants?
12:30 Why are adjuvants used in many vaccines?
14:08 Protein production from mRNA
15:00 Why utilize the extra step of mRNA to code for protein antigens?
17:28 Are mRNA vaccines the future of vaccine development?
19:18 Any chance for mRNA to enter our cells' nucleus?
20:55 The immune response to a coronavirus vaccine
23:17 Expected symptoms from immune response to a vaccine vs. vaccine side effects
25:50 Should people who've had COVID-19 get vaccinated?
27:27 Immunity from COVID vaccine vs. a natural infection
28:30 Why does the Pfizer vaccine need to be stored so cold?
29:04 What would you say to a family member who is nervous about a rushed vaccine and RNA technology?
32:37 What about the possibility of long term side effects from RNA vaccines?
33:30 What's next for Shane Crotty's research team?

(This video was recorded on December 16, 2020).

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PREVIOUS / RECENT MEDCRAM COVID-19 INTERVIEWS:

Vitamin D and COVID 19: The Evidence for Prevention and Treatment of Coronavirus (SARS CoV 2) with Professor Roger Seheult, MD

At Home COVID 19 Antigen Testing and Vaccine Update with Professor Michael Mina, MD

All coronavirus updates are at MedCram.com ad-free (including more videos on the Pfizer vaccine, Moderna vaccines, BioNTech vaccine, vaccine side effects, COVID 19 vaccine mechanism, AstraZeneca Oxford coronavirus vaccine, side effects of COVID 19 vaccine, COVID 19 treatments, and more):

We offer over 60 medical topics (ECG Interpretation, DKA, influenza, measles, mechanical ventilation, etc.) on our website and CME for clinicians.


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DISCLAIMER:

MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
#COVID19 #SARSCoV2 #Coronavaccine

October 2018 ACIP Meeting - General Recommendations; Influenza; Rabies; Meningococcal; Pertussis

Vaccine Administration – Vaccinators with conditions that are contraindications or precautions; Influenza vaccine effectiveness in preventing influenza-associated hospitalizations during pregnancy; Fluzone Quadrivalent 0.5-mL dose for children aged 6 through 35 Months; Rabies Workgroup update; Meningococcal Workgroup update; Pertussis Workgroup update; Background to current ACIP recommendations (Td and Tdap) and policy considerations for Tdap revaccination

Comments on this video are allowed in accordance with our comment policy:


This video can also be viewed at

First Responders: SARS-CoV-2 and the Immune System

The immune system fights SARS-CoV-2 infection, but it also causes serious clinical symptoms when it rages out of control. In this webinar from The Scientist, Angela Rasmussen and Ya-Chi Ho will discuss how the immune system reacts to SARS-CoV-2, whether these responses are beneficial or deleterious, and the mechanisms by which immune responses determine COVID-19 severity and patient outcomes.

Lung immune cells as drivers of influenza outcomes

Presented By: Juliet Morrison, PhD

Speaker Biography: Dr. Juliet Morrison is an Assistant Professor at the University of California Riverside. Her research combines immunological and virological methods with computational analysis to address questions at the host-pathogen interface. A major interest of the Morrison Lab is understanding how emerging and re-emerging viruses antagonize innate immune pathways to promote their replication.

Webinar: Lung immune cells as drivers of influenza outcomes

Webinar Abstract: nfluenza severity is determined by the interplay between the virus and the host response. Previously, we identified a three-pronged lung gene expression signature that predicted severe influenza outcomes in mice. We hypothesized that this signature resulted from differential activation or infiltration of immune cells in the lungs during mild versus severe influenza infection. In order to build a comprehensive model of lung immune dynamics in response to influenza virus infections

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Black In Immuno Week 2020 Innate Immunity Talks

This event will feature TEDx style talks suited for those inside and outside of academia. The talks will feature work in innate immunology work, the first line of defense in the immune system.

Speakers and their talk titles:
-Antonia Cuff, a doctoral student at Imperial College London
Title: How to give babies more time in their mother's womb (8:48)
1:14:05 - Do the IL-22 knockout mice reproduce okay?
1:29:48 - Do you know if ILC3s are interacting with uterine epithelial cells or other immune cells to mediate their function? What are they doing when pregnancies are not successful?

-De'Broski Herbert, Ph.D., an Associate Professor at the University of Pennsylvania School of Veterinary Medicine
Title: Overcoming barriers, pushing limits, and dispelling imposter myth (22:02)
1:17:03 - Does your work support the divergent role for IL-33?
1:33:33 - Where did your quote come from? Did you write it? If so, what inspired you?

-Berenice Mbiribindi, Ph.D., a Senior Postdoctoral Research Fellow at Stanford University School of Medicine
Title: The impact of viral peptides on natural killer cell function (40:00)
1:14:57 - Does your work support the emerging concept of innate memory?
1:15:58 - Would the mechanisms you see arise in other viral injections, like cytomegalovirus, or is it unique to Epstein Barr Virus?
1:31:46 - How do peptides affect the interaction with NKG2C? Do their peptides make a difference with the binding?

-Juliet Morrison, Ph.D., an Assistant Professor at the University of California Riverside
Title: Innate immune drivers of influenza severity (54:06)
1:21:32 - Describe the phenotype of pleural macrophages. How are they distinct from other macrophages? Are there any emerging technologies to better characterize them?
1:32:57 - Are pleural macrophages similar to peritoneal macrophages that contribute to clot formation?

You can use #BlackInImmunoInnate to keep the conversation going and ask questions.
Transcripts are available here:

Questions timestamp (1:07:15):
1:08:14 - What is the passion for your work? (Dr. Mbiribindi, Dr. Herbert, Antonia Cuff, and Dr. Morrison)
1:23:46 - How do you see your work helping to better understand COVID-19? (Dr. Herbert, Dr. Mbiribindi, Dr. Morrison, Antonia Cuff)
1:37:03 - What is something that has given you life as you navigate being Black in immunology? (Dr. Morrison, Dr. Mbiribindi, Antonia Cuff)
1:43:00 - What does true allyship look like? (Dr. Morrison, Antonia Cuff, Dr. Mbiribindi)
1:48:21 - Share when your mentor was an incredible ally or was there a time when you wish your mentor served as an ally? (Dr. Mbiribindi, Dr. Morrison, Antonia Cuff)
1:51:47 - How can we improve our connections to the community and try to rebuild trust in science? (Dr. Morrison, Dr. Mbiribindi, Antonia Cuff)
1:56:12 - What does it mean to be Black In Immuno? (Dr. Mbiribindi, Antonia Cuff, Dr. Morrison)

Emerging Pandemic: Costs and Consequences of an Avian Influenza Outbreak

Nearly four decades have passed since the world last saw an influenza pandemic, many believe we are long overdue for another. Dr. Michael Osterholm and Helen Branswell mark the inauguration of the Global Health Initiative.

Understanding Viruses: Coronaviruses, Influenza and other Viral Pathogens

Join Professors Peter Daniel, Carol St. Angelo and Nathan Rigel from Hofstra University's Biology department for a presentation that introduces non-experts to the world of viruses. Topics covered include how different viruses infect human cells and replicate once they are inside, as well as how the immune system defends against viral attacks.

Protecting the Vulnerable During COVID-19: How to Stay Healthy this Flu Season

The Canadian Frailty Network (CFN) presents Protecting the Vulnerable During COVID-19: How to Stay Healthy this Flu Season. In this webinar experts from the healthcare field will answer your questions on why influenza impacts older adults more heavily, what vaccinations are recommended, and how getting your vaccinations can help protect you and those around you!

Host: Dr. John Muscedere, CEO and Scientific Director of the Canadian Frailty Network

Moderator: Laura Tamblyn-Watts, President and CEO of CanAge

Panelists:

Dr. Mark Loeb, Professor of Medicine, McMaster University

Dr. Melissa Andrew, Associate Professor of Medicine, Dalhousie University

Dr. Kumanan Wilson, Professor of Medicine, University of Ottawa

Tags
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Online Seminars

Online Health Seminars

#vaccination

#seniors

#vaccine

#olderadults

#frailty

#healthyaging

#covid19

#flushot

ILSI: COVID-19- Nutrition in Immune Response Against Viral Infection

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