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Splicing and Dicing DNA: Genome Engineering and the CRISPR Revolution

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CRISPR in Context: The New World of Human Genetic Engineering

It’s happened. The first children genetically engineered with the powerful DNA-editing tool called CRISPR-Cas9 have been born to a woman in China. Their altered genes will be passed to their children, and their children’s children. Join CRISPR’s co-discoverer, microbiologist Jennifer Doudna, as we explore the perils and the promise of this powerful technology. It is not the first time human ingenuity has created something capable of doing us great good and great harm. Are we up to the challenge of guiding how CRISPR will shape the future?

PARTICIPANTS: Jennifer Doudna, Jamie Metzl, William Hurlbut

MODERATOR: Guy McKhann

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PARTICIPANTS:

TOPICS
0:00 - Introduction
1:55 - Jennifer Doudna introduction
2:25 - How do we learn to use CRISPR technology wisely?
3:29 - The basics of understanding CRISPR
6:04 - Genetic engineering explainer film
7:39 - How can CRISPR help the worldwide food chain?
9:57 - Genetic disease treatment
14:25 - Improving quality of life
15:55 - Designer babies
17:55 - The gene drive
19:25 - Confronting the ethical implications of CRISPR
23:55 - Jennifer’s childhood in Hawaii
28:25 - Patents
32:08 - Importance of accuracy
32:40 - Germ cells vs somatic cells
35:58 - He Jiankui controversy
40:05 - What makes CRISPR dangerous?
43:48 - How do we enforce regulation of CRISPR use?
53:50 - The aftermath of He Jiankui’s work
1:09:25 - How do we make CRISPR technology accessible globally?
1:14:00 - How do we balance natural biology and CRISPR?
1:18:44 - How will CRISPR impact our future as a species?

PROGRAM CREDITS
- Produced by Nils Kongshaug
- Associate Produced by Emmalina Glinskis
- Music provided by APM
- Additional images and footage provided by: Getty Images, Shutterstock, Videoblocks.
- Recorded at the Simons Foundation's Gerald D. Fishbaum Auditorium

The Kavli Prize recognizes scientists for their seminal advances in astrophysics, nanoscience, and neuroscience. The series, “The Big, the Small, and the Complex,” is sponsored by The Kavli Foundation.

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What is CRISPR & How Could It Edit Your DNA?

Gene-editing tool CRISPR is everywhere in the news, but what is it and could it eliminate disease?

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Should We Make Designer Babies? ►►►►

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CRISPR: A game-changing genetic engineering technique

Have you heard? A revolution has seized the scientific community. Within only a few years, research labs worldwide have adopted a new technology that facilitates making specific changes in the DNA of humans, other animals, and plants.

CRISPR gene therapy: Scientists call for more public debate around breakthrough technique

The technique, known as CRISPR, could revolutionise human gene therapy and genetic engineering because it allows scientists for the first time to make the finest changes to the DNA of the chromosomes with relative ease.
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Meet the biohacker using CRISPR to teach everyone gene editing

Meet the biohacker who wants to teach everyone how to edit genes

Josiah Zayner is a biohacker who thinks everyone should be able to change their DNA with biotechnology called CRISPR. That’s why he founded a company called The ODIN, which sells do-it-yourself biotech kits that teach people how to genetically modify bacteria and frogs. It's DIY gene therapy.

His company has sold tens of thousands of experiments using CRISPR, an inexpensive and precise gene-editing technology that has revolutionized the field.

Find more on CRISPR at Quartz

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Quartz is a digital news outlet dedicated to telling stories at the intersection of the important and the interesting. Visit us at to read more.

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MUTANT MENU | The Ethics of Gene Editing

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If you could, would you design your DNA? And should you be able to?

Gene editing technologies, including CRISPR, have the potential to save lives and cure disease; but using them also comes with risk. In this documentary, I talk to experts around the world to explore the scientific potential and societal implications – and let you come to your own conclusions about this technology. So, would you like to place an order?

BrainCraft was created by Vanessa Hill (@nessyhill) and is brought to you by PBS Digital Studios. Talking psychology, neuroscience & why we act the way we do.

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Mutant Menu was supported by Screen Australia and YouTube through the Skip Ahead initiative.
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Into the Future with CRISPR Technology with Jennifer Doudna

(4:54 - Main Presentation, 54:36 - Q&A)
Jennifer Doudna, co-discoverer of CRISPR-Cas9, discusses how genome editing with CRISPR technology is transforming biology. CRISPR-Cas9, an RNA-guided enzyme with remarkable abilities to recognize and cleave DNA, operates by mechanisms that both explain its biological function and provide insights into technology development. Doudna covers research into this amazing family of proteins: where they came from, how they work and how CAS-9-based technologies are revolutionizing research, biomedicine and agriculture. Recorded on 10/07/2019. [11/2019] [Show ID: 35215]

UCTV is the broadcast and online media platform of the University of California, featuring programming from its ten campuses, three national labs and affiliated research institutions. UCTV explores a broad spectrum of subjects for a general audience, including science, health and medicine, public affairs, humanities, arts and music, business, education, and agriculture. Launched in January 2000, UCTV embraces the core missions of the University of California -- teaching, research, and public service – by providing quality, in-depth television far beyond the campus borders to inquisitive viewers around the world.
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DNA Science - Human Race and Genetics Documentary

Splicing and Dicing DNA: Genome Engineering and the CRISPR Revolution

CRISPR: It’s the powerful gene editing technology transforming biomedical research. Fast, cheap and easy to use, it allows scientists to rewrite the DNA in just about any organism—including humans—with tests on human embryos already underway. The technique’s potential to radically reshape everything from disease prevention to the future of human evolution has driven explosive progress and heated debate. Join the world’s CRISPR pioneers to learn about the enormous possibilities and ethical challenges as we stand on the threshold of a brave new world of manipulating life’s fundamental code.

This program is part of the Big Ideas Series, made possible with support from the John Templeton Foundation.

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Original Program Date: June 3 2016
MODERATOR: Richard Besser
PARTICIPANTS: George Church, Luke Dow, Josephine Johnston, Ben Matthews, Harry Ostrer, Noel Sauer

What is CRISPR? 00:05

Introduction by Richard Besser 3:58

Participant Introductions. 5:02

What is so powerful about CRISPR? 7:25

How is CRISPR is used? 13:00

How will CRISPR help eliminate Zika Virus? 20:45

Modifying 60 genes at once in a pig. 26:02

What are potential agricultural advantages from CRISPR? 28:44

If you have eaten CRISPR cells? 35:00

Using a gene drives to eliminate virus? 37:40

Creating an off switch for CRISPR 40:27

How is it ethical to not rid the world of malaria? 42:55

What is the difference between editing a germ line and editing a cancer cell? 48:27

Why would the first CRISPR baby create backlash? 58:48

How do we regular CRISPR used in military applications? 1:06:33

What is the regulation to be expected from CRISPR? 1:13:09

What does a CRISPR-ised world look like? 1:16:00

Splicing and Dicing DNA: Genome Engineering and the CRISPR Revolution

CRISPR: The Revolution in Genetics

CRISPR is a revolutionary new technique that allows scientists to precisely edit the activity of genes and thus influence the characteristics of all manner of organisms, from microscopic bacteria to humans. Should we use this technology to prevent harmful diseases in humans being passed on between generations? And should we go even further and use it to enhance our offspring, making them fitter, healthier and more intelligent?

In the last episode of this series of the Life Science Broadcast, zoology professor Matthew Cobb and renowned bioethicist John Harris discuss the applications of CRISPR technology and just how far we should go in using it to change our genomes.

Filmed and produced by Edward Bains, The University of Manchester.

CRISPR Science: DNA, RNA, and Gene Editing

This video provides a quick refresher on DNA before introducing gene-editing. In five minutes you get both a lesson on DNA and CRISPR, which is pronounced crisp-er. If you already know the basics of DNA you can jump to the CRISPR section at 3:22. To learn more about this tool you can visit the companion story on Ask A Biologist -
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It's Alive, But Is It Life: Synthetic Biology and the Future of Creation

For decades, biologists have read and edited DNA, the code of life. Revolutionary developments are giving scientists the power to write it. Instead of tinkering with existing life forms, synthetic biologists may be on the verge of writing the DNA of a living organism from scratch. In the next decade, according to some, we may even see the first synthetic human genome. Join a distinguished group of synthetic biologists, geneticists and bioengineers who are edging closer to breathing life into matter.

This program is part of the Big Ideas Series, made possible with support from the John Templeton Foundation.

Original Program Date: June 4, 2016
MODERATOR: Robert Krulwich
PARTICIPANTS: George Church, Drew Endy, Tom Knight, Pamela Silver

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Synthetic Biology and the Future of Creation
00:05

Participant Intros 3:25

Ordering DNA from the internet 8:10

How much does it cost to make a synthetic human? 13:04

Why is yeast the best catalyst 20:10

How George Church printed 90 billion copies of his book 26:05

Creating synthetic rose oil 28:35

Safety engineering and synthetic biology 37:15

Do we want to be invaded by bad bacteria? 45:26

Do you need a human gene's to create human cells? 55:09

The standard of DNA sequencing in utero 1:02:27

The science community is divided by closed press meetings 1:11:30

The Human Genome Project. What is it? 1:21:45

Hack your DNA with CRISPR - VPRO documentary - 2018

You won't be able to blame it on your genetics anymore: with CRISPR, it's so easy to hacn into your DNA. CRISPR technology is our future, and experiments with DNA hacking are booming. CRISPR biotechnology is not science fiction anymore, it is our very near future. Would you hack and reprogram your own DNA with CRISPR? Breaking the code of life, hacking DNA at home.

Welcome to the world of a new nature. We can now literally cut and paste DNA with the new CRISPR technology. There is a revolutionary development going on that will have major consequences for humans, plants and animals. The new biotechnology is here.

'Bio is the New Digital'. We are able to accurately reprogram the genetic code of our body cells, embryos, bacteria, viruses and plants. With the CRISPR technology we can adjust the characteristics of each organism to our needs. This allows us to permanently ban diseases, improve our body conditions and adapt plants to our food needs.

The special feature of CRISPR technology is that it is relatively simple. In the past year, the number of experiments and applications has exploded. Around the world, people have been tinkering with CRISPR: experimenting at home with the 'Do it Yourself CRISPR kits'.

Scientists call for new ethical frameworks. The demand for the (un)desirable so-called designer babies is imminent. Although this is not yet the case, we can put an end to hereditary diseases in the short term. We may also want to make bacteria that can eat oil or plastic, pigs in which human organs can grow or bring extinct animals back to life.
It looks like science fiction but it is now closer to our reality than ever.
With: Emmanuelle Charpentier (geneticist), John van der Oost (microbiologist), Andrew Hessel (biotechnologist), Niels Geijsen (cell biologist), Josiah Zayner (biohacker) and Ivan van der Meij (FSHD patient).

Originally broadcasted by VPRO in 2018.
© VPRO Backlight Mars 2018

On VPRO broadcast you will find nonfiction videos with English subtitles, French subtitles and Spanish subtitles, such as documentaries, short interviews and documentary series.
VPRO Documentary publishes one new subtitled documentary about current affairs, finance, sustainability, climate change or politics every week. We research subjects like politics, world economy, society and science with experts and try to grasp the essence of prominent trends and developments.

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Credits:
Director: Rob van Hattum
Research: William de Bruijn
English, French and Spanish subtitles: Ericsson.
French and Spanish subtitles are co-funded by European Union.

Genetic Engineering : How Is Bacteria Used in Genetic Engineering?

Bacteria is used abundantly in genetic engineering to study life, disease and medicine. Understand how scientists use bacteria on a regular basis with information from a biochemistry professor in this free video on genetic engineering.

Expert: M. Rahman
Bio: M. Rahman is a professor of bio chemistry at University of California San Diego.
Filmmaker: Bing Hugh

Transgenics and Gene Splicing modification LK 17;26 as it was in the days of NOE

Promise and peril of gene-editing technology CRISPR

CRISPR could help rid of diseases like cystic fibrosis, muscular dystrophy and even HIV and cancer. But many scientists, including Jennifer Doudna who is credited with developing the gene-editing technology, are calling for a moratorium on its use. Only on “CBS This Morning,” Doudna tells Norah O'Donnell why, for all its promise, CRISPR is surrounded by controversy.
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What is CRISPR? Jennifer Doudna on cutting and pasting DNA

2015 Breakthrough Prize laureate Jennifer Doudna talks about the medical promise and ethical challenges of the CRISPR-Cas9 gene-editing technology.

CRISPR Makes Biology the New Digital

CRISPR gene editing is one of the most powerful discoveries of our time. It will transform our future by creating or curing disease, creating or killing species, and effecting anything that we manufacture. CRISPR is set to change everything.




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XPRIZE is an educational (501c3) nonprofit organization whose mission is to bring about radical breakthroughs for the benefit of humanity, thereby inspiring the formation of new industries and the revitalization of markets that are currently stuck due to existing failures or a commonly held belief that a solution is not possible. XPRIZE addresses the world's Grand Challenges by creating and managing large-scale, high-profile, incentivized prize competitions that stimulate investment in research and development worth far more than the prize itself. It motivates and inspires brilliant innovators from all disciplines to leverage their intellectual and financial capital.

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VIDEO CREDITS

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U.S. scientists try 1st gene editing in the body to change a person's DNA to cure a disease

Scientists for the first time have tried editing a gene inside the body to permanently change a person’s DNA to cure a disease.

What if we could rewrite the human genome?

Berkeley biochemist and CRISPR expert Sam Sternberg shares the thrilling story of how basic science research in the immune responses of bacteria led to an incredible tool to edit human DNA.

Genetically modified dogs: Chinese scientists use CRISPR to create muscly freaks - TomoNews

GUANGZHOU, CHINA — Scientists of the Key Laboratory of Regenerative Biology at the Guangzhou Institutes of Biomedicine and Health claim to be the first to use genome modification to double the muscle mass of dogs.

Their findings, recently published in the latest edition of the Journal of Molecular Cell Biology, have broken new ground in the field of genetic engineering. For this new research, the scientists used 65 beagle dog embryos, focusing in on genes encoded for myostatin, a protein that inhibits muscle growth. By injecting the enzyme complex CRISPR-Cas9 into the embryos, the objective was to knock out the myostatin genes in the DNA of the canines. With myostatin deleted, the beagles would be able to reach new levels of muscle growth.

The breakthrough study resulted in the births of 27 beagle puppies. The scientists report only two of them, a boy they named Hercules and a girl they named Tiangou, had disruptions in their myostatin genes. The researchers say that the gene editing turned out to be incomplete in Hercules, allowing for a percentage of his muscle cells to continue to produce myostatin. But with Tiangou, the gene editing was indeed complete, resulting in her thigh muscles growing to be significantly larger than those of her litter mates. The scientists say the dogs have more muscles and are expected to have stronger running ability, which could make for freakishly powerful hunting dogs and military canines.

In the past, the Chinese have performed gene editing on goats, rabbits, rats, monkeys and even human embryos. While the scientists say this particular study was undertaken to learn more about gene modification for human disease treatments, such as Parkinson’s and muscular dystrophy, it’s hard not to wonder what else they might do.

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