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The Coronavirus Vaccine Explained | COVID-19

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The Coronavirus Vaccine Explained | COVID-19

The truth about the race to a coronavirus vaccine
Are Vaccines Causing Magnetism?
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Coronavirus Update 118: AstraZeneca DNA COVID 19 Vaccine Explained (vs. Pfizer / BioNTech, Moderna)

Professor Roger Seheult, MD discusses the AstraZeneca and Oxford DNA COVID-19 Vaccine: How it works, and what we know about the safety, efficacy, and side effects at this time.

Dr. Seheult illustrates the differences and similarities between the AstraZeneca / Oxford vaccine candidate and those from Moderna and Pfizer / BioNTech.

The complete data from each of these SARS CoV 2 vaccine trials have not been released nor peer-reviewed at this time, and none of the COVID 19 vaccines have received FDA authorization to date.

Dr. Sheult explains some of the potential advantages of the AstraZeneca Oxford vaccine candidate including a lower cost and that it only requires regular refrigeration. (This video was recorded on November 24, 2020).

Roger Seheult, MD is the co-founder and lead professor at
He is Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine and an Associate Professor at the University of California, Riverside School of Medicine.


LINKS / REFERENCES:

Johns Hopkins Tracker |

Worldometer |

AstraZeneca press release |

AstraZeneca-Oxford Covid-19 Vaccine Up to 90% Effective in Late-Stage Trials (Wall Street Journal) |

Why the AstraZeneca-Oxford Covid-19 vaccine is different (Vox) |

Why the Pfizer and BioNTech vaccine is a cause for optimism — and skepticism (Vox) |

AstraZeneca Registered Trial in US |

Pfizer claims its Covid-19 vaccine is 90 percent effective so far. Here’s what we actually know. (Vox) |

These Covid-19 vaccine candidates could change the way we make vaccines — if they work (Vox) |

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RECENT PREVIOUS COVID-19 UPDATES:

Please visit MedCram.com for the full series:
- Coronavirus Update 117: Moderna vs. Pfizer COVID 19 Vaccine (mRNA vaccines)
- Coronavirus Update 116: Pfizer COVID 19 Vaccine Explained (Biontech)
- Coronavirus Update 115: Convalescent Plasma vs Monoclonal Antibodies for COVID 19 Treatment
- Coronavirus Update 114: COVID 19 Death Rate Drops; NAC (N acetylcysteine) Data
- Coronavirus Update 113: Remdesivir May Not Work for COVID 19
- Coronavirus Update 112: Linoleic Acid; Vaccines; UK COVID 19 Data
- Coronavirus Update 111: Masks; New Vitamin D Data and COVID 19; NAC
- Coronavirus Pandemic Update 110: Trump's Risk Factors and COVID-19 Prognosis; Interferon
- Coronavirus Pandemic Update 109: New Data From Europe As COVID 19 Infections Rise
- Coronavirus Pandemic Update 108: High Risk COVID 19 Behaviors; Cases Rise in Europe
- Coronavirus Pandemic Update 107: Monoclonal Antibodies for COVID 19 Treatment and Prevention?

All coronavirus updates are at MedCram.com (including monoclonal antibody treatment vs convalescent plasma treatment, COVID vaccine, mRNA vaccine, COVID 19 prevention, Pfizer vaccine and Moderna vaccines, Biontech, AstraZeneca Oxford coronavirus vaccine, COVID 19 treatments, COVID-19 vaccine updates, and more).
We offer over 60 medical topics (ECG Interpretation, DKA, influenza, measles, mechanical ventilation, etc.) on our website.


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MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
#COVID19 #SARSCoV2
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COVID-19 Vaccine: How Does It Affect Your Body?

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This video explains what happens in your body when you get the COVID-19 mRNA vaccine, including how the vaccine helps your immune system recognize and fight the COVID-19 virus, possible side effects from the vaccine, and how long before you are fully-vaccinated against the virus after receiving the vaccine.

Hash tags: #CoronavirusVaccine #COVID19Vaccine #CoronavirusImmunization
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Coronavirus Update 116: Pfizer COVID 19 Vaccine Explained (Biontech)

Professor Roger Seheult, MD discusses the Pfizer / Biontech COVID-19 mRNA vaccine: How it works and what we know about the safety and efficacy at this time.

No mRNA vaccine has ever been approved by the FDA, but Pfizer and BioNTech hope to receive emergency approval based on preliminary data from their ongoing vaccine trial.

This two-dose vaccine regimen has limitations including the need for -70 C refrigeration and many questions remain:
Will the vaccine prevent transmission and asymptomatic spread?
How long will immunity last?
Will “90% effective” hold up to peer-review and additional data when it is gathered?

(This video was recorded on November 12, 2020).

Dr. Seheult is the co-founder and lead instructor at


LINKS / REFERENCES:

Johns Hopkins Tracker |

Worldometer |

COVID-19 vaccine tracker (RAPS) |

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates (NEJM) |

A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates (bioRxiv) |

Pfizer and BioNTech Announce Vaccine Candidate Against COVID-19 Achieved Success in First Interim Analysis from Phase 3 Study (BioNTech) |

Why mRNA represents a disruptive new drug class {BioNTech) |


THE MEDCRAM WEBSITE:

Visit us for videos on over 60 medical topics and CME / CEs for medical professionals:


SUBSCRIBE TO THE MEDCRAM YOUTUBE CHANNEL:


Get notified of new videos by hitting the bell icon:


RECENT PREVIOUS COVID-19 UPDATES:

Please visit MedCram.com for the full series:
- Coronavirus Update 115: Convalescent Plasma vs Monoclonal Antibodies for COVID 19 Treatment
- Coronavirus Update 114: COVID 19 Death Rate Drops; NAC (N acetylcysteine) Data
- Coronavirus Update 113: Remdesivir May Not Work for COVID 19
- Coronavirus Update 112: Linoleic Acid; Vaccines; UK COVID 19 Data
- Coronavirus Update 111: Masks; New Vitamin D Data and COVID 19; NAC
- Coronavirus Pandemic Update 110: Trump's Risk Factors and COVID-19 Prognosis; Interferon
- Coronavirus Pandemic Update 109: New Data From Europe As COVID 19 Infections Rise
- Coronavirus Pandemic Update 108: High Risk COVID 19 Behaviors; Cases Rise in Europe
- Coronavirus Pandemic Update 107: Monoclonal Antibodies for COVID 19 Treatment and Prevention?
- Coronavirus Pandemic Update 105: FDA Authorized Treatments; COVID 19 Vaccine Update
- Coronavirus Pandemic Update 103: Convalescent Plasma Treatment & the FDA; College Campuses Close

All coronavirus updates are at MedCram.com (including monoclonal antibody treatment vs convalescent plasma treatment, COVID vaccine, COVID 19 prevention, Pfizer vaccine, Biontech, coronavirus vaccine, COVID 19 treatments, COVID-19 vaccine updates, and more).
We offer over 60 medical topics (ECG Interpretation, DKA, influenza, measles, mechanical ventilation, etc.) on our website.


MEDCRAM WORKS WITH MEDICAL PROGRAMS AND HOSPITALS:

MedCram offers group discounts for students and a variety of medical programs, hospitals, and other institutions. Contact us at customers@medcram.com if you are interested.


MEDIA CONTACT:

Roger Seheult, MD
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.
Associate Professor at the University of California, Riverside School of Medicine

Media Contact: customers@medcram.com
Media contact info:

Video Produced by Kyle Allred

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DISCLAIMER:

MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
#COVID19 #SARSCoV2
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COVID-19 coronavirus vaccine: everything you need to know

The Cambridge scientists developing a COVID-19 coronavirus vaccine

Professor Jonathan Heeney explains why we need a vaccine against the new COVID-19 coronavirus and how his team is using new technology developed for influenza and Ebola viruses to target the new infection.
Thumbnail Credit - Fusion Animation

What Is An mRNA Coronavirus Vaccine?

More than 30 biotech and pharmaceutical companies around the world are racing to develop a safe Covid-19 vaccine. The process is moving quickly with several vaccine candidates entering late-stage trials in a matter of months. Two of the companies developing a vaccine — Pfizer and Moderna — are utilizing a promising new technology called messenger RNA. Watch the video to learn why experts believe this vaccination method could be a game-changer for getting back to normal.

CORRECTION At 0:30, this video misstated the number of companies chosen by the White House to receive ‘fast track’ designation from Operation Warp Speed. Vaccine projects from Sanofi, in partnership with GSK, and Novavax also received fast-track status.

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What Is An mRNA Coronavirus Vaccine?

Coronavirus Update 117: Moderna vs. Pfizer COVID 19 Vaccine (mRNA vaccines)

Professor Roger Seheult, MD discusses the Moderna COVID-19 mRNA vaccine: How it works and what we know about the safety, efficacy, and side effects at this time.

No mRNA vaccine has ever been approved by the FDA, but Moderna and Pfizer/BioNTech hope to receive emergency approval based on preliminary data from their ongoing vaccine trials.

Moderna's two-dose vaccine regimen does not require special refrigeration (the Pfizer vaccine is supposed to be stored at -70 Celcius) but a variety of questions remain:
Will the vaccine prevent transmission and asymptomatic spread?
How long will immunity last?
Will “94.5% effective” hold up to peer-review and additional data when it is gathered?

(This video was recorded on November 17, 2020).

Dr. Seheult is the co-founder and lead instructor at


LINKS / REFERENCES:

Johns Hopkins Tracker |

Worldometer |

Outcomes for Out-of-Hospital Cardiac Arrest in the United States During the Coronavirus Disease 2019 Pandemic (JAMA Cardiology) |

Moderna’s Covid-19 vaccine is strongly effective, early look at data show (STAT) |

mRNA Platform: Enabling Drug Discovery & Development (Moderna) |

What is mRNA? (Moderna) |

Moderna’s COVID-19 Vaccine Candidate Meets its Primary Efficacy Endpoint in the First Interim Analysis of the Phase 3 COVE Study (Moderna) |


THE MEDCRAM WEBSITE:

Visit us for videos on over 60 medical topics and CME / CEs for medical professionals:


SUBSCRIBE TO THE MEDCRAM YOUTUBE CHANNEL:


Get notified of new videos by hitting the bell icon:


RECENT PREVIOUS COVID-19 UPDATES:

Please visit MedCram.com for the full series:
- Coronavirus Update 116: Pfizer COVID 19 Vaccine Explained (Biontech)
- Coronavirus Update 115: Convalescent Plasma vs Monoclonal Antibodies for COVID 19 Treatment
- Coronavirus Update 114: COVID 19 Death Rate Drops; NAC (N acetylcysteine) Data
- Coronavirus Update 113: Remdesivir May Not Work for COVID 19
- Coronavirus Update 112: Linoleic Acid; Vaccines; UK COVID 19 Data
- Coronavirus Update 111: Masks; New Vitamin D Data and COVID 19; NAC
- Coronavirus Pandemic Update 110: Trump's Risk Factors and COVID-19 Prognosis; Interferon
- Coronavirus Pandemic Update 109: New Data From Europe As COVID 19 Infections Rise
- Coronavirus Pandemic Update 108: High Risk COVID 19 Behaviors; Cases Rise in Europe
- Coronavirus Pandemic Update 107: Monoclonal Antibodies for COVID 19 Treatment and Prevention?
- Coronavirus Pandemic Update 105: FDA Authorized Treatments; COVID 19 Vaccine Update
- Coronavirus Pandemic Update 103: Convalescent Plasma Treatment & the FDA; College Campuses Close

All coronavirus updates are at MedCram.com (including monoclonal antibody treatment vs convalescent plasma treatment, COVID vaccine, mRNA vaccine, COVID 19 prevention, Pfizer and Moderna vaccines, Biontech, coronavirus vaccine, COVID 19 treatments, COVID-19 vaccine updates, and more).
We offer over 60 medical topics (ECG Interpretation, DKA, influenza, measles, mechanical ventilation, etc.) on our website.


MEDCRAM WORKS WITH MEDICAL PROGRAMS AND HOSPITALS:

MedCram offers group discounts for students and a variety of medical programs, hospitals, and other institutions. Contact us at customers@medcram.com if you are interested.


MEDIA CONTACT:

Roger Seheult, MD
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.
Associate Professor at the University of California, Riverside School of Medicine

Media Contact: customers@medcram.com
Media contact info:

Video Produced by Kyle Allred

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DISCLAIMER:

MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
#COVID19 #SARSCoV2

Coronavirus Update 127: Delta Variant and Vaccines

Professor Roger Seheult, MD of MedCram with an update on the effectiveness of four major vaccines against the delta variant of COVID-19: Pfizer / BioNTech, Moderna, AstraZeneca, and Johnson and Johnson Vaccine (This video was recorded on July 19, 2021).

See the video Dr. Seheult references: 10 Tips if you Get COVID-19 here:

Please see our most recent video on Previous Infection vs. The Delta Variant:


TOPICS IN THIS VIDEO INCLUDE:

00:00 General overview of SARS-CoV-2 variants
02:44 Characteristics of the SARS-CoV-2 delta variant (B.1.617.2)
03:21 Preliminary data on delta variant infection rates by age & risk of severe infection
05:14 How delta variant is affecting COVID-19 case numbers in the UK, Israel, and United States
06:55 How do the COVID-19 vaccines stack up against delta variant? Effectiveness of Pfizer-BioNTech vaccine
12:20 Data on the effectiveness of Moderna vaccine against the delta variant
12:42 Data on effectiveness of Oxford-AstraZeneca vaccine against the delta variant
13:41 Information on Johnson & Johnson vaccine effectiveness against related SARS-CoV-2 variants (no current data on delta variant)
15:29 Vaccination rates across the United States
17:04 What to do if you’re infected with COVID-19?


Roger Seheult, MD is the co-founder and lead professor at
He is Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine and an Associate Professor at the University of California, Riverside School of Medicine.


LINKS / REFERENCES:

5 Things To Know About the Delta Variant (Yale Medicine) |

REACT-1 round 12 report: resurgence of SARS-CoV-2 infections in England associated with increased frequency of the Delta variant (Imperial College) |

SARS-CoV-2 Delta VOC in Scotland: demographics, risk of hospital admission, and vaccine effectiveness (The Lancet) |

Vaccines highly effective against B.1.617.2 variant after 2 doses (GOV.UK) |

Effectiveness of COVID-19 vaccines against hospital admission with the Delta (B.1.617.2) variant (Public Health England) |

Moderna Provides a Clinical Update on the Neutralizing Activity of its COVID-19 Vaccine on Emerging Variants Including the Delta Variant First Identified in India (Moderna) |

How much protection COVID-19 vaccines give you against the Delta variant, according to the best available data (Business Insider) |

The total number and mass of SARS-CoV-2 virions (NIH) |

Covid vaccine: How many people in the UK have been vaccinated so far? (BBC News) |

All coronavirus updates are at MedCram.com (including more discussion on delta variant covid, delta plus variant COVID, COVID delta variant, and more).


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MedCram offers group discounts for students and medical programs, hospitals, and other institutions. Contact us at customers@medcram.com if you are interested.


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Media Contact: customers@medcram.com
Media contact info:

Video Produced by Kyle Allred


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DISCLAIMER:

MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.

#COVID19 #SARSCoV2 #Coronavirus

Coronavirus Vaccines vs. NON COVID-19 related deaths (New Data)

Roger Seheult, MD of MedCram discusses lower non COVID-19 death rates in COVID-19 vaccine recipients.
Interesting new data published in MMWR by the CDC. MedCram COVID 19 Update 135

(This video was recorded on November 8, 2021)

Roger Seheult, MD is the co-founder and lead professor at
He is Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine and an Associate Professor at the University of California, Riverside School of Medicine.


LINKS / REFERENCES:

COVID-19 Vaccination and Non–COVID-19 Mortality Risk — Seven Integrated Health Care Organizations, United States, December 14, 2020–July 31, 2021 (CDC) |

COVID Vaccine Myths, Questions, and Rumors with Rhonda Patrick and Roger Seheult (MedCram) |

All coronavirus updates are at MedCram.com (including more discussion on the COVID delta variant, moderna, pfizer booster, and more).


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Get notified of new videos by hitting the bell icon

MEDCRAM WORKS WITH MEDICAL PROGRAMS AND HOSPITALS:

MedCram offers group discounts for students and medical programs, hospitals, and other institutions. Contact us at customers@medcram.com if you are interested.


MEDIA CONTACT:

Media Contact: customers@medcram.com
Media contact info:

Video Produced by Kyle Allred


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DISCLAIMER:

MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.

#COVID19 #SARSCoV2 #Coronavirus

Delta Variant Versus Previous COVID 19 Infection vs. Vaccines (Coronavirus Update 128)

Roger Seheult, MD of MedCram explains how natural immunity (from a previous COVID-19 infection) compares with vaccines (Pfizer, Moderna, AstraZeneca) VS. the Delta coronavirus variant. (This video was recorded on July 24, 2021).

Correction: Strasbourg is in France (near the German border), not in Germany.

TOPICS IN THIS VIDEO INCLUDE:

00:00 Is natural immunity from previous COVID-19 infection strong enough against Delta variant?
00:32 Research study of 50,000+ patients from the Cleveland Clinic
03:07 Qatar airport study shows previous infection with SARS-CoV gives reasonable immunity against reinfection
05:46 UK data suggests low risk of COVID-19 reinfection among population
07:04 Study on antibody response effectiveness (from vaccines and natural infection) at neutralizing several COVID-19 variants, including Delta
13:33 Monoclonal antibodies shown to have little effectiveness against Delta variant
14:31 Patients urged to get both doses of Pfizer or Moderna, especially for protection against Delta variant
14:59 MedCram resources for medical providers treating COVID-19 patients and the case for lung ultrasounds

Roger Seheult, MD is the co-founder and lead professor at
He is Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine and an Associate Professor at the University of California, Riverside School of Medicine.

See the video Dr. Seheult references about Lung Ultrasound in COVID 19:

LINKS / REFERENCES:

Can You Get Delta Variant if You Already Had COVID-19? (Healthline) |

Necessity of COVID-19 vaccination in previously infected individuals (medRxiv) |

Associations of Vaccination and of Prior Infection With Positive PCR Test Results for SARS-CoV-2 in Airline Passengers Arriving in Qatar (JAMA) |

New national surveillance of possible COVID-19 reinfection, published by PHE (GOV.UK) |

Study highlights need for full Covid vaccination to protect against Delta variant (STAT) |

All coronavirus updates are at MedCram.com (including more discussion on delta variant covid, delta plus variant COVID, COVID delta variant, and more).


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MedCram offers group discounts for students and medical programs, hospitals, and other institutions. Contact us at customers@medcram.com if you are interested.


MEDIA CONTACT:

Media Contact: customers@medcram.com
Media contact info:

Video Produced by Kyle Allred


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DISCLAIMER:

MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.

#COVID19 #Deltavariant #Coronavirus
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Inside the Lab That Invented the COVID-19 Vaccine

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Here we are, just a year after the first news of the coronavirus we now call SARS-CoV-2 and the global pandemic known as COVID-19… and scientists have already developed more than one safe & effective vaccine. How did they do that so quickly? I visited the lab whose work directly led to these first COVID vaccines, so you can learn how basic research connects to life-saving medicine. This is how to make a COVID-19 vaccine.

Coronavirus animation courtesy of: Janet Iwasa, University of Utah, with funding from the NSF, the Coronavirus Structural Task Force and the German Federal Ministery of Research

References:
Wrapp, D. et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science 367, 1260–1263 (2020) doi: 10.1126/science.abb2507

Watanabe, Y., Allen, J. D., Wrapp, D., McLellan, J. S. & Crispin, M. Site-specific glycan analysis of the SARS-CoV-2 spike. Science eabb9983 (2020) doi:10.1126/science.abb9983.

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Does a vaccine spell the end of the coronavirus pandemic? | DW Documentary

A vaccine against COVID-19 is considered the only realistic hope of overcoming the virus. Several vaccines have now been approved. But does that mean an end to the pandemic and a return to normal life are in sight?

A heated debate has broken out over whether we have enough vaccine and who will get it first: those who need it most urgently - or those who pay most? Many countries have long since reached lucrative deals with pharmaceutical companies to secure exclusive rights to millions of vaccine doses. Poorer states that cannot compete in the bidding are at risk of going empty-handed. If this is not prevented, global health apartheid will become more entrenched, driving inequality to new heights. And the pandemic will still be with us, warns Indian economist Jayati Ghosh.

The documentary takes us to some of the most important locations and centers of vaccine development and distribution – in Germany, the United States, Britain and India. Pharmaceutical developers worldwide have allowed the film team exclusive access to their research laboratories, where operations are normally kept strictly secret.

As we look at the countdown to vaccine development, we find a huge project at a crossroads: Will it prove possible not only to develop an effective vaccine against the new coronavirus but also to distribute it to the entire global population? Or will national egoisms ultimately torpedo the collective global effort?


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What The COVID Vaccine Does To Your Body

Is the coronavirus vaccine safe? Now that the first COVID19 vaccine from Pfizer is being released, how do mRNA vaccines work?
Are Vaccines Causing Magnetism?
Watch this BRILLIANT live stream on vaccines with Dr. Alex Dainis:
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There’s a lot of excitement right now around the record-speed vaccines for COVID19, some of which are already starting distribution in parts of the world. But given that these are mRNA vaccines - a relatively new technology that has not been widely used before - we wanted to explain how they work, and what happens in your body from the moment the needle touches your skin.

Written by Gregory Brown and Mitchell Moffit
Editing by Luka Šarlija

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NYC announces one of the strictest COVID vaccine mandates in U.S.

New York City Mayor Bill de Blasio announced one of the nation's strictest COVID-19 vaccination mandates, forcing all private businesses to require their workers to get their shots within the next three weeks. Nikki Battiste has more.

CBS Evening News with Norah O'Donnell delivers the latest news and original reporting, and goes beyond the headlines with context and depth. Catch the CBS Evening News every weekday night at 6:30 p.m. ET on the CBS Television Network and at 10 p.m. ET on CBSN.

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From Smallpox To The Coronavirus: The History Of Vaccinations Explained | NBC News

Dr. Josefa Steinhauer explains the history of the first human vaccine and the early days of the anti-vaxx movement.
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From Smallpox To The Coronavirus: The History Of Vaccinations Explained | NBC Nightly News
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RNA Vaccines (mRNA Vaccine) - Basis of Pfizer and Moderna COVID-19 vaccines, Animation

The basis of upcoming Pfizer and Moderna coronavirus vaccines. How it works? Pluses and minuses. For comparison of different vaccines, as well as events of immune response, role of different immune cells (T-cells, B-cells, APC), see this video:
This video is available for instant download licensing here:
©Alila Medical Media. All rights reserved.
Support us on Patreon and get early access to videos and free image downloads: patreon.com/AlilaMedicalMedia
All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
Vaccines prepare the immune system, getting it ready to fight disease-causing organisms, called pathogens. A vaccine is introduced to the body to mimic infection, triggering the body to produce antibodies against the pathogen, but without causing the illness. Conventional vaccines usually contain a weakened or inactivated pathogen; or a piece of a protein produced by the pathogen, called an antigen.
RNA vaccines are a new generation of vaccines. Instead of the antigen itself, RNA vaccines contain a messenger RNA – mRNA - that encodes for the antigen. Once inside the body’s cells, the mRNA is translated into protein, the antigen, by the same process the cells use to make their own proteins. The antigen is then displayed on the cell surface where it is recognized by the immune system. From here, the sequence of events is similar to that of a conventional vaccine.
Some RNA vaccines also contain additional mRNA coding for an enzyme, which, after being translated in host cells, can generate multiple copies of the antigen-encoding mRNA. This essentially amplifies the production of antigen from a small amount of vaccine, making the vaccine more effective. These are called self-amplifying RNA vaccines.
RNA vaccines are easier and safer to produce than conventional vaccines. This is because mRNA molecules can be synthesized in a cell-free system using a DNA template with a sequence of the pathogen; while conventional vaccines usually require a more complicated and risk-prone process of growing large amounts of infectious pathogens in chicken eggs or other mammalian cells. Without the risks of being contaminated by infectious elements or allergens from egg cultures, RNA vaccines are also safer for patients.
Because protein synthesis occurs in the cytoplasm, RNA molecules do not need to enter the nucleus, so the possibility of them integrating into the host cell genome is low. RNA strands are usually degraded by cellular enzymes once the protein is made.
The relative simplicity of the production process makes it easier to standardize and scale, enabling rapid responses to emerging pandemics. Other advantages include lower production costs, and the ease of tweaking RNA sequences to adapt to rapidly-mutating pathogens.
On the minus side, it can be challenging to deliver mRNA effectively to the cells, since RNA sequences and secondary structures may be recognized and destroyed by the innate immune system as soon as they are administered intravenously. These limitations can be overcome by optimizing codons, using modified nucleosides to avoid recognition, and packaging RNA into protective nanoparticles.
Another disadvantage is that most RNA vaccines require uninterrupted refrigeration for transportation and storage, which can be a hurdle for vaccine distribution. Research is ongoing to engineer thermostable vaccines.

Why US anti-vaxxers will refuse the coronavirus vaccine

In a recent survey, 24% of Americans said they will refuse a coronavirus vaccine. Adam Gabbatt investigates the anti-vaxxer movement in the United States – and how the Covid pandemic is helping to fuel its resurgence
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WHO’s Science in 5 on COVID-19 : Vaccines explained - 12 February 2021

Science in 5 series - episode #25 / If you have had COVID-19, should you still get vaccinated ? Why are we not vaccinating children under 16? WHO’s Chief Scientist Dr Soumya Swaminathan explains these and other vaccine related questions in Science in 5 this week.

Information Regarding COVID-19 Vaccine (COVID-19 वैक्सीन के बारे में जानकारी) #vaccinesahihai ????????????????????

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Information Regarding COVID-19 Vaccine - Everything you need to know about Covaxin and Covishield

Is it mandatory to take the vaccine?
Vaccination for COVID-19 is voluntary. However, it is advisable to receive the complete schedule of COVID-19 vaccine for protecting one-self against this disease and also to limit the spread of this disease to the close contacts including family members, friends, relatives and co-workers.

Will the vaccine be safe as it is being tested and introduced in a short span of time?
Vaccines will be introduced in the country only after the regulatory bodies clear it based on its safety and efficacy.

Is it necessary for a COVID recovered person to take the vaccine?
Yes, it is advisable to receive complete schedule of COVID vaccine irrespective of past history of infection with COVID-19. This will help in developing a strong immune response against the disease.

Out of the multiple vaccines available, how is one or more vaccine chosen for administration?
The safety and efficacy data from clinical trials of vaccine candidates are examined by Drug regulator of our country before granting the license for the same. Hence, all the COVID-19 vaccines that receive license will have comparable safety and efficacy. However, it must be ensured that the entire schedule of vaccination is completed by only one type of vaccine as different COVID-19 vaccines are not interchangeable.

Will the vaccine introduced in India be as effective as the ones introduced in other countries?
Yes. The COVID-19 vaccine introduced in India will be as effective as any vaccine developed by other countries. Various phases of vaccine trials are undertaken to ensure its safety and efficacy.

If one is taking medicines for illnesses like Cancer, Diabetes, Hypertension etc, can s/he take the COVID-19 vaccine?
Yes. Persons with one or more of these comorbid conditions are considered high risk category. They need to get COVID-19 vaccination.

What about the possible side-effects from COVID-19 vaccine?
COVID vaccine will be introduced only when the safety is proven. As is true for other vaccines, the common side effects in some individuals could be mild fever, pain, etc. at the site of injection. States have been asked to start making arrangements to deal with any Covid-19 vaccine-related side-effects as one of the measures towards safe vaccine delivery among masses.

#vaccinesahihai #covid19vaccine #covidvaccine #COVAXIN #Covishield #covid #covishieldvaccine #covaxinnews #covishieldvscovaxin #covid19vaccine #coronavaccine

India scraps local trials for well-established imported COVID-19 vaccine | Coronavirus Vaccination

In an effort to boost the vaccination program, India has decided to phase out local trials for well-established foreign coronavirus vaccines. India had promised to accelerate imports last month, but a dispute over local tests and a dispute over indemnification stalled discussions with Pfizer.

#IndiaVaccination #VaccineTrials #COVID19

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