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The electrical blueprints that orchestrate life | Michael Levin

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The electrical blueprints that orchestrate life | Michael Levin

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DNA isn't the only builder in the biological world -- there's also a mysterious bioelectric layer directing cells to work together to grow organs, systems and bodies, says biologist Michael Levin. Sharing unforgettable and groundbreaking footage of two-headed worms, he introduces us to xenobots -- the world's first living robots, created in his lab by cracking the electrical code of cells -- and discusses what this discovery may mean for the future of medicine, the environment and even life itself. (This conversation, hosted by TED's Chris Anderson, was recorded June 2020.)

The TED Talks channel features the best talks and performances from the TED Conference, where the world's leading thinkers and doers give the talk of their lives in 18 minutes (or less). Look for talks on Technology, Entertainment and Design -- plus science, business, global issues, the arts and more. You're welcome to link to or embed these videos, forward them to others and share these ideas with people you know.

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The innovations we need to avoid a climate disaster | Bill Gates

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The single most important thing for avoiding a climate disaster is cutting carbon pollution from the current 51 billion tons per year to zero, says philanthropist and technologist Bill Gates. Introducing the concept of the green premium -- the higher price of zero-emission products like electric cars, artificial meat or sustainable aviation fuel -- Gates identifies the breakthroughs and investments we need to reduce the cost of clean tech, decarbonize the economy and create a pathway to a clean and prosperous future for all. (This virtual conversation, hosted by TED Global curator Bruno Giussani, was recorded in March 2021.)

Countdown is TED's global initiative to accelerate solutions to the climate crisis. The goal: to build a better future by cutting greenhouse gas emissions in half by 2030, in the race to a zero-carbon world. Get involved at

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TED's videos may be used for non-commercial purposes under a Creative Commons License, Attribution–Non Commercial–No Derivatives (or the CC BY – NC – ND 4.0 International) and in accordance with our TED Talks Usage Policy ( For more information on using TED for commercial purposes (e.g. employee learning, in a film or online course), please submit a Media Request at
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The value of your humanity in an automated future | Kevin Roose

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To futureproof your job against robots and AI, you should learn how to code, brush up on your math skills and crack open an engineering textbook, right? Wrong. In this surprisingly comforting talk, tech journalist Kevin Roose makes the case that rather than trying to compete with the machines, we should instead focus on what makes us uniquely human.

The TED Talks channel features the best talks and performances from the TED Conference, where the world's leading thinkers and doers give the talk of their lives in 18 minutes (or less). Look for talks on Technology, Entertainment and Design -- plus science, business, global issues, the arts and more. You're welcome to link to or embed these videos, forward them to others and share these ideas with people you know.

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TED's videos may be used for non-commercial purposes under a Creative Commons License, Attribution–Non Commercial–No Derivatives (or the CC BY – NC – ND 4.0 International) and in accordance with our TED Talks Usage Policy ( For more information on using TED for commercial purposes (e.g. employee learning, in a film or online course), please submit a Media Request at
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Enhancing Healthy Adolescent Development

Enhancing Healthy Adolescent Development
Dr. Dawn-Elise Snipes PhD, LPC-MHSP, LMHC


CEUs are available for this presentation at AllCEUs


Want to listen to it as a podcast instead? Subscribe to Counselor Toolbox Podcast

Objectives
 Identify the developmental tasks of adolescents and what can be done to facilitate those
 Review unique points to remember when dealing with adolescents
 Identify protective factors
 Identify antecedents to high risk behaviors
 Brainstorm ways to address antecedents with the individual, in school, in communities and in families
Developmental Tasks of Adolescence
Points to Remember
 Adolescents are competent individuals with strengths and potential
 Adolescents are diverse in their developmental stages and their abilities to comprehend and respond to specific tasks and expectations.
 Adolescent behavior is meaningful to the adolescent.
 Adolescents desire a sense of belonging, wish to participate in decisions, and have a voice about issues that affect their lives.
Points to Remember
 Build on adolescent’s strengths
 Much of the morbidity and mortality during adolescence is related to unhealthy or risky behaviors (e.g. smoking, drinking and
driving, unprotected sex, drug use, violence)
 Adolescents who engage in one risky behavior are more likely to engage in others
 Focus on the antecedents of high-risk behavior instead of the behavior itself

Antecedents to High Risk Behaviors
 Adverse Childhood Experiences
 Abuse, neglect or victimization—Experienced or witnessed IPV
 Divorce and separation
 Mental health or substance abuse issues in the household
 Undiagnosed learning disabilities
 School failure
 Academic failure was a greater risk factor for later adolescent drinking than adolescent drinking was for later academic failures

Addressing Antecedents Adolescent Brain Development
 The brain matures from “back” to “front. ” Adolescent decision-making behaviors are more influenced by the amygdala than the prefrontal cortex:
 Decision-making is influenced by emotional/gut responses vs. higher order cognitions
 The pre-frontal cortex is responsible for planning, strategizing, judgment, impulse control and regulation of emotions
 Initial “growth spurt” at 11-12 years and continues through 25 years
 From 12-12 there is a pruning process of unused neuronal connections
 The temporal gap between the development of the socio-emotional and cognitive control systems of the brain underlies some aspects of adolescent reckless behavior and risk-taking
Comprehensive Health
 Healthy young people learn better and achieve more.
 Schools can directly influence students’ health and behaviors.
 Schools and communities can encourage healthy lifestyle choices, and promotes adolescent health and well-being.
 Health literacy can be incorporated into all aspects of school as well as recreation
 Schools, families and communities need to collaborate with youth to develop workable strategies

Strategies
 Enhance cognitive “wise mind” processing during adolescence to retain those synapses
 Actively engage youth by providing opportunities for meaningful participation and sustained involvement in protective activities
 Develop resiliency skills
 Enhance protective factors
Protective Factors
 Family support
 Positive family communication
 Clear and consistent boundaries and expectations
 Other adult relationships
 Encouragement to develop relationships
 Connection to the family, school and community
 Youth are provided opportunities to be useful resources (meaningful participation)
 Youth feel emotionally and physically safe
 Planning and decision making
 Resiliency:
 Problem solving
 Efficacy
 Social support
 Communication skills
 Mindfulness/self-awareness
 Self-esteem
 Distress tolerance
 Resistance and refusal skills
 Positive view of the future
 Cultural competence


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#addiction and #mentalhealth #counselors, #socialworkers and marriage and family therapists can earn #CEUs for this and other presentations at AllCEUs.com

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Michael Levin: Anatomical decision-making by cellular collectives

Anatomical decision-making by cellular collectives: Bioelectrical pattern memories, regeneration, and synthetic living organisms.

A key question for basic biology and regenerative medicine concerns the way in which evolution exploits physics toward adaptive form and function.  While genomes specify the molecular hardware of cells, what algorithms enable cellular collectives to reliably build specific, complex, target morphologies?  Our lab studies the way in which all cells, not just neurons, communicate as electrical networks that enable scaling of single-cell properties into collective intelligences that solve problems in anatomical feature space. By learning to read, interpret, and write bioelectrical information in vivo, we have identified some novel controls of growth and form that enable incredible plasticity and robustness in anatomical homeostasis. In this talk, I will describe the fundamental knowledge gaps with respect to anatomical plasticity and pattern control beyond emergence, and discuss our efforts to understand large-scale morphological control circuits. I will show examples in embryogenesis, regeneration, cancer, and synthetic living machines. I will also discuss the implications of this work for not only regenerative medicine, but also for fundamental understanding of the origin of bodyplans and the relationship between genomes and functional anatomy.

Dr. Michael Levin - Tufts University - Reading and Writing the Bio-Electric Morphogenetic Code

Dr. Michael Levin is a Tufts University professor who holds the Vannevar Bush endowed Chair in the Biology department, and who serves as both the Director of the Tufts Center for Regenerative and Developmental Biology and Director, Allen Discovery Center at Tufts.


Dr. Levin’s group's focus is on understanding the bio-physical mechanisms that implement decision-making during complex pattern regulation, and harnessing endogenous bio-electric dynamics toward rational control of growth and form.


The lab's current main directions are:


• Understanding how somatic cells form bio-electrical networks for storing and recalling pattern memories that guide morphogenesis;


• Creating next-generation AI tools for helping scientists understand top-down control of pattern regulation (a new bioinformatics of shape);


and


• Using these insights to enable new capabilities in regenerative medicine and engineering.


Dr. Levin he got dual B.S. degrees, in Computer Science and in Biology and then received a PhD from Harvard University. He did post-doctoral training at Harvard Medical School, where he began to uncover a new bio-electric language by which cells coordinate their activity during embryogenesis. His independent laboratory (2000-2007 at Forsyth Institute, Harvard; 2008-present at Tufts University) develops new molecular-genetic and conceptual tools to probe large-scale information processing in regeneration, embryogenesis, and cancer suppression.


Recent honors include the Scientist of Vision award and the Distinguished Scholar Award.

Bio-Electricity For Regeneration and Cancer Control

Ira Pastor, ideaXme life sciences ambassador and founder of Bioquark, interviews Dr. Michael Levin, Tufts University Professor who holds the Vannevar Bush endowed Chair in the Biology Department, and who serves as both the Director of the Tufts Center for Regenerative and Developmental Biology and Director of the Allen Discovery Center at Tufts.

Ira Pastor comments:

Form is generally defined as the shape and structure of something as distinguished from the materials that it’s constructed from, and the branch of biology that deals with the form of living organisms, and with the relationships between their structures, is known as morphology.

Every level of the human body requires complex form control mechanisms to be functional throughout a lifetime, across the body's many hierarchies (at the levels of DNA, cells, tissues, organs, limbs, and body segments), in order to accomplish a range of biologic outputs from embryogenesis, to growth, repair and regeneration, to preventing everything from tumor formation to transitions into a range of degenerative disease, to even neuro-plasticity in the human brain.

Yet, when it comes to topics like shape, size, polarity, position, where the properties and characteristics of the component parts of a system and the reciprocal interplay of all the components on each across these hierarchies are required, researchers need to go well beyond studying an individual gene or protein or stem cell, to a range of fascinating top-down control processes which control complex biological morphology.

Today, we have the honor of being joined by a true thought leader of this space, Dr. Michael Levin, Tufts University Professor who holds the Vannevar Bush endowed Chair in the Biology Department, and who serves as both the Director of the Tufts Center for Regenerative and Developmental Biology and Director of the Allen Discovery Center at Tufts.

Dr. Levin Researches the Utilization of Bio-electricity for Regeneration:

Dr. Levin’s group's focus is on understanding the biophysical mechanisms that implement decision-making during complex pattern regulation and harnessing endogenous bioelectric dynamics toward rational control of growth and form.

Dr. Levin's lab current focus:

• Understanding how somatic cells form bioelectrical networks for storing and recalling pattern memories that guide morphogenesis.

• Creating next-generation AI tools for helping scientists understand top-down control of pattern regulation (a new bioinformatics of shape).

• Using these insights to enable new capabilities in regenerative medicine and engineering.

Dr. Levin's recent honors include the Scientist of Vision award and the Distinguished Scholar Award.

On this episode we will hear from Dr. Levin about:

His background and how he became interested in computer science, biology, and the extremely frontier science space of biological morphology control. The introductory concept of a “Morphogenetic Field.” An introduction to the theme of Developmental Bioelectricity which refers to the regulation of cell, tissue, and organ-level patterning and behavior as the result of endogenous electrically-mediated signaling.

A general theme of the ability of morphogenetic fields and developmental bioelectricity to organize in/out required cells, as well as modify the diseased phenotype, as seen in his experiments in “normalizing” cancer. A general theme of the ability of morphogenetic fields and developmental bioelectricity to accomplish complex regeneration. His views on developmental bioelectricity modulating drugs versus using electroceuticals. His model of Variational Free-Energy Minimization as a way for human bodies to store complex pattern information.

His work in non-CNS information processing, storage, and cognition - such as in aneural organisms which do not possess brains, in non-neural human tissues, and in single cell organisms that agglomerate to form multi-cellular structures, like slime moulds. His experiences in fundraising for frontier sciences, such as with The Paul G. Allen Frontiers Group (the late Microsoft co-founder) whose mission is to uncover and make visible the emerging frontiers of science, identifying pioneering explorers to create new knowledge, and produce important solutions that make the world better.

This interview is in American English


Credits: Ira Pastor interview video, text, and audio.
Follow Ira Pastor on Twitter: @IraSamuelPastor
If you liked this interview, be sure to check out our interview with David Mittelstein
on Killing Cancer With Ultrasound!

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ideaXme is a global podcast, creator series and mentor programme. Our mission: Move the human story forward!™ ideaXme Ltd.

The Regenerative Wisdom of The Body: Michael Levin



In a short presentation that provides a wealth of critical information, Michael Levin reports on the work of his lab at Tufts University on research into how animals control growth and form. All cells, not just nerve cells, communicate electrically, and evidence is growing that it is bioelectrical circuits that play the key role in the plasticity of shape and anatomy. His lab has shown the ability to induce whole organ formation, trigger regeneration, reprogram tumors, and repair birth defects – to radically change the body plan without editing the genome.

Science And NonDuality is a community inspired by timeless wisdom, informed by cutting-edge science, and grounded in personal experience. We come together in an openhearted exploration to further our individual and collective evolution. New ways of being emerge. We embody our interconnectedness and celebrate our humanity.

Endogenous Bioelectric Networks & Regenerative Medicine

Michael Levin, PhD, Director of the Allen Discovery Center at Tufts, and Tufts Center for Regenerative and Development Biology at Tufts University, presented innovative research in the fascinating fields of bioelectric networks and regenerative medicine.

In this presentation, Dr. Levin sketched a roadmap for regenerative medicine focused on manipulating the bioelectric pattern memories in tissue (as distinct to popular approaches of micromanaging molecular pathways), and described advances in the areas of repair of birth defects, limb regeneration, and cancer reprogramming.

He first discussed some fundamental problems of cell and developmental biology that must be solved to gain complete control over growth and form.

Dr. Levin also described developmental bioelectricity and the tools his group has created to modulate voltage-based signals that orchestrate cell behavior toward building and repairing complex anatomies.

Biography
Michael Levin, PhD, originally trained in computer science and artificial intelligence. Interested in novel ways to store and process information, he moved into biology to understand how living tissue performs computation during morphogenesis. He received his PhD from the genetics department at Harvard Medical School, identifying the first genes regulating the left-right asymmetry of the embryonic bodyplan. His laboratory is at Tufts University, where he is Vannevar Bush professor of biology, and director of the Allen Discovery Center.

Levin’s group is focused on understanding the mechanisms and algorithms by which cells are harnessed toward the creation and repair of complex anatomies. His lab specializes in understanding the bioelectrical signals that all cells (not just neurons) enable coordination and decision-making at the organ level. Using a combination of molecular embryology, biophysics, and computational modeling, they develop biomedical applications and new advances in machine learning and robotics inspired by the software of life.

Picasso Tadpoles: Michael Levin on the 'Dark Matter' of Biology

Dr. Michael Levin of Tufts University crosses many disciplines: computer science, embryo development, cancer and tumor research; limb regeneration; evolutionary theory and neural networks.

If you watch Michael's fascinating talk at he'll take you down his magical rabbit hole including worms that grow new heads when you cut them in half, tumors that heal themselves and eyes planted on tails that actually work.

In this interview, Michael explodes the myth that we've got it mostly figured out.

The truth is closer to 1% understanding and 99% is Dark Matter.

Discover Michael's research at and
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Mad Money w/ Jim Cramer » Red Light On EV SPACs, Reviewing 2020 IPOs & PAR Technology CEO

Must-Hear Podcasts » Mad Money w/ Jim Cramer » Red Light On EV SPACs, Reviewing 2020 IPOs & PAR Technology CEO w/ Panera Founder
»»»»»»»»»»»»»»»»»»»»»»»»»»»

The Dow broke an all-time high today, climbing xx points, and Jim Cramer is breaking down the index's move higher and what drove the action. Then, with a plethora of EV SPACs coming public, how should investors know when to pump the brakes? Cramer's telling investors which companies might deserve the red light. Next, Cramer's going back and reviewing some of the biggest IPO debuts of 2020 and how the companies have fared since coming public. Plus, PAR Technologies CEO Savneet Singh joins Panera Founder Ron Shaich to talk about which COVID-19 changes and impact on the restaurant industry could last long after the pandemic ends.

Regeneration & Xenobots with Dr. Michael Levin of The Levin Lab | Build The Future Podcast

In this episode of Build The Future, we talk with Dr. Michael Levin, Principal Investigator at The Levin Lab, where their goal is to understand how individual cell behaviors are orchestrated towards appropriate large-scale outcomes despite unpredictable environmental perturbations.

Links:



To listen to more episodes and to stay connected, follow along at:



Don’t forget to subscribe and click the bell to be notified when new episodes come out.

Until next time, go build!

Mike Levin - Live ALife 2020 Keynote - Robot Cancer

Michael Levin, Vannevar Bush Professor; Director, Allen Discovery Center at Tufts; Director, Tufts Center for Regenerative and Developmental Biology, Department of Biology, Tufts University; Associate Faculty, Wyss Institute for Biologically Inspired Engineering, Harvard University

Talk title: Robot Cancer: what the bioelectrics of embryogenesis and regeneration can teach us about unconventional computing, cognition, and the software of life

Talk Abstract: Today's engineered robots are often made from reliable yet dumb parts, which greatly limits their adaptive functionality but ensures that their subsystems do not defect from the overall purpose. In contrast, a key aspect of Life is that biological systems have competency at each level - they are made of collectives of cells, tissues, organs, etc. each of which has local goals, which orchestrates the noise and fragility at lower levels towards highly robust system-level behaviors. The cooperation and competition across scales in living systems results in great plasticity, and in basal cognition - memory and decision-making outside the brain that can provide essential inspiration for artificial life and robotics. In this talk, I will outline the remarkable properties of complex body regeneration in some species, in which cellular collectives remember and work toward a specific anatomical outcome. We have now uncovered some of the mechanisms by which cells represent target morphologies and execute the anatomical homeostasis that enables them to reach these goals despite radical perturbations. The mechanism of this error reduction loop and pattern memory is bioelectrical, and I will describe the new tools with which we can now directly read out these anatomical setpoints in all cell types. Best of all, we can now re-write them in vivo, producing lines of 2-headed flatworms and other drastically altered animal anatomies by brief modulation of the bioelectric patterning software running on genomically un-edited (wild-type) cellular hardware. By cracking the morphogenetic code and understanding how anatomical decisions are implemented by distribute bioelectrical computations in tissues, we get closer to our endgame: a reverse anatomical compiler that will enable top-down design of living form at the level of patterning modules, not by micromanaging the molecular machine code on which much of biology is focused today. I will conclude by sketching out the implications of this field for not only biomedicine but also for new machine learning architectures and for the creation of computer-designed living organisms. The future belongs to a deep consilience of computer science, cognitive science, and biology to understand the plasticity of multi-scale computational systems and greatly broaden the boundaries of life-as-it-could-be.

15 minutes Binary Numbers inside the Computer

Within the next 15 minutes you will …

- be able to count in binary
- know why and how computers use binary numbers
- name the main components of a CPU
- understand data and control flow
- trace the function of a simple CPU

Michael Levin (U Chicago) An introduction to string-net models @Harvard CMSA 3/25/2021

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3/25/2021

Michael Levin (U Chicago)

Title: An introduction to string-net models
Abstract: String-net models are exactly solvable lattice models that can realize a large class of (2+1)D topological phases. I will review basic aspects of these models, including their Hamiltonians, ground-state wave functions, and anyon excitations. I will also discuss the relationship between the original string-net models, proposed in 2004, and the more recent, “generalized’’, string-net models.
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Chuck Mangione (The Day After) Our First Night Together Main Squeeze (1976)

Best of Steve Gadd (Discography) ... Playlist
Acoustic Guitar – Bob Mann, John Tropea
Art Direction – Roland Young (3)
Concertmaster – Gene Orloff
Design – Junie Osaki
Drums – Steve Gadd
Electric Bass – Tony Levin
Electric Guitar – Bob Mann, John Tropea
Electric Piano [Fender Rhodes] – Chuck Mangione, Don Grolnick
Engineer – Mick Guzauski
Engineer [Assistant] – Michael Frondelli
Flugelhorn, Orchestrated By – Chuck Mangione
French Horn – Bob Carlisle, Fred Griffen*, Jimmy Buffington*, John Clark (2)
Management – Tom Iannaccone
Mastered By – Frank DeLuna
Organ – Richard Tee
Percussion – Ralph MacDonald, Rubens Bassini, Steve Gadd
Photography By – Ian Patrick
Piano [Acoustic] – Don Grolnick
Producer – Chuck Mangione
Trombone – Bill Watrous, Dave Taylor*, Tom Malone, Wayne Andre
Trumpet – Alan Rubin, Jeff Tkazyik, John Faddis*, Lew Soloff

How bad data keeps us from good AI | Mainak Mazumdar

Visit to get our entire library of TED Talks, transcripts, translations, personalized talk recommendations and more.

The future economy won't be built by people and factories, but by algorithms and artificial intelligence, says data scientist Mainak Mazumdar. But what happens when these algorithms get trained on biased data? Drawing on examples from Shanghai to New York City, Mazumdar shows how less-than-quality data leads to AI that makes wrong decisions and predictions -- and reveals three infrastructural resets needed to make ethical AI possible.

The TED Talks channel features the best talks and performances from the TED Conference, where the world's leading thinkers and doers give the talk of their lives in 18 minutes (or less). Look for talks on Technology, Entertainment and Design -- plus science, business, global issues, the arts and more. You're welcome to link to or embed these videos, forward them to others and share these ideas with people you know.

Become a TED Member:
Follow TED on Twitter:
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Subscribe to our channel:

TED's videos may be used for non-commercial purposes under a Creative Commons License, Attribution–Non Commercial–No Derivatives (or the CC BY – NC – ND 4.0 International) and in accordance with our TED Talks Usage Policy ( For more information on using TED for commercial purposes (e.g. employee learning, in a film or online course), please submit a Media Request at

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Artist Name : Michael V.
Album Title : The Bubble G Anthology
Release Date: 2006
Record Label: OctoArts
Running Time: 38 Minutes
No.of Tracks: 10 Tracks

TRACKLIST :
00:00 01 Joy In My Heart
02:04 02 Hindi Ako Bakla
06:01 03 DJ Bumbay
10:16 04 'Wag Na 'Wag
14:24 05 Chaka N'ya
19:38 06 Di Na Mag-Gigisa
23:27 07 'Wag N'yo Kaming Pansinin
27:28 08 Isaw Nga
32:05 09 May B.O. Na Ako
36:06 10 Mag-Exorcist Tayo

OPM NATION
All Rights Reserved
2020

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Chuck Mangione Love The Feelin' Main Squeeze (1976)

Best of Steve Gadd (Discography) ... Playlist
Acoustic Guitar – Bob Mann, John Tropea
Art Direction – Roland Young (3)
Concertmaster – Gene Orloff
Design – Junie Osaki
Drums – Steve Gadd
Electric Bass – Tony Levin
Electric Guitar – Bob Mann, John Tropea
Electric Piano [Fender Rhodes] – Chuck Mangione, Don Grolnick
Engineer – Mick Guzauski
Engineer [Assistant] – Michael Frondelli
Flugelhorn, Orchestrated By – Chuck Mangione
French Horn – Bob Carlisle, Fred Griffen*, Jimmy Buffington*, John Clark (2)
Management – Tom Iannaccone
Mastered By – Frank DeLuna
Organ – Richard Tee
Percussion – Ralph MacDonald, Rubens Bassini, Steve Gadd
Photography By – Ian Patrick
Piano [Acoustic] – Don Grolnick
Producer – Chuck Mangione
Trombone – Bill Watrous, Dave Taylor*, Tom Malone, Wayne Andre
Trumpet – Alan Rubin, Jeff Tkazyik, John Faddis*, Lew Soloff

2/21/12: Harnessing the Bioelectric Potential of Cells for Regeneration

Michael Levin, Ph.D., Vannevar Bush Professor in the Department of Biology, Tufts University, and Director of the Tufts Center for Regenerative and Developmental Biology. Minute voltage variations in cells orchestrate crucial functions such as anatomical development in the embryo, defense mechanisms against cancer, the repair and in some organisms regeneration of damaged organs and limbs.

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