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Vitamin D3 (Cholecalciferol) and Vitamin D2 (Ergocalciferol) and Calcitriol

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Vitamin D3 (Cholecalciferol) and Vitamin D2 (Ergocalciferol) and Calcitriol

The Vitamin D supplement that I take:


Vitamin D3, Cholecalciferol, Vitamin D2, Ergocalciferol, Calcidiol, Calcitriol.

What are all of these things? They are all referring to the various forms of vitamin D in our body, or in the food we eat. Vitamin D3 is also known as cholecalciferol, this is the form made naturally by the body in response to sunlight. Vitamin D2 is also known as Ergocalciferol and comes from plants. Vitamin D supplements come in the form of either Vitamin D3 or Vitamin D2. Calcitriol, or 1,25-Dihydroxyvitamin D if you prefer, is the active form of vitamin D in our body. When sunlight contains ultraviolet B (UVB) radiation, and when it hits your skin cells, it turns 7-dehydrocholesterol into vitamin D3, meaning cholecalciferol. Vitamin D3 in turn binds to vitamin D-binding protein (VDBP) and is transported to the liver, where it gets converted to calcidiol, aka 25-hydroxyvitamin D.

Calcidiol is the storage form of vitamin D in the body. Calcidiol is later converted to the active form of vitamin D in the body, meaning calcitriol, or 1,25-Dihydroxyvitamin D. This conversion of calcidiol into calcitriol mainly occurs in the kidney. But it also takes place in different tissues and cells of the immune system, such as lymph nodes and alveolar macrophages. And not only in alveolar macrophages, but the alveoli themselves.

Vitamin D3 is only found naturally in a few different food sources, mainly fatty fish, like cod, swordfish, tuna, and salmon. Milk doesn’t naturally contain vitamin D3, but it has been fortified with it for almost 100 years now. But other dairy products made from milk like cheese and ice cream aren’t typically fortified with vitamin D and contain only small amounts. For older adults to meet the RDA of 800 IU, they would have to drink about 4 cups of fortified milk per day. Vitamin D3 mainly comes from sunlight though, not food. But the skin’s production of vitamin D depends on a number of factors, only some of which you have control of.

Depending on the season, where you live, where you travel, the time of day, the clothing you wear, the umbrella that you use, all of these factors determine how much UVB light hits your skin. The sun’s rays are most direct between 10 a.m. and 3 p.m. However, the farther you live from the equator, the less UVB radiation you receive. People who live north of about 37° latitude can’t make any vitamin D from sunlight from November to March, even if they spend all day outside bare naked. Why is this the case? During the winter months, the earth tilts away from the sun, ultimately leading to less sun rays hitting the earth. Having darker skin means less UVB absorption, which means less vitamin D3 production. Also, as we age, our body become less efficient at converting UVB light into vitamin D3. This is why older people, as well as darker skin people, are more prone to have lower vitamin D levels. To make matters worse, many older people have reduced exposure to sunlight for different reasons, and may not be getting enough vitamin D in their diet.

Vitamin D signals the intestines to absorb calcium into the bloodstream.
This happens even if you have enough calcium in your diet. Besides strengthening bones, vitamin D helps reduce fractures in the elderly by preventing muscle deterioration, and reducing the chances of falling.

The official definition of a vitamin deficiency means that specific health problems arise as a direct result of not having enough of a specific nutrient. True vitamin D deficiency in children causes rickets, a bone disease where the legs become bowed. This is rare in the United States. Vitamin D deficiency in adults can lead to osteomalacia and osteoporosis, leading to bone fractures. So what if you don’t have deficiency per se, but you have less-than-ideal levels of a specific vitamin? Well, this can increase your risk of various health issues, even though they are not solely responsible for these problems. This is what we call “Insufficiency.”

Most medical societies consider someone vitamin D insufficiency if their level is between 12 to 20 ng/mL (30 to 50 nmol/L), and Vitamin D deficiency is a level less than 12 ng/mL (30 nmol/L). Most experts consider normal levels being above 20 and less than 50 ng/ml. Most people in the United States have values around 20 ng/ml.

But having too high levels can cause other health issues. In one study, levels above 32 ng/ml resulted in people getting less quality sleep. The risk of vitamin D toxicity typically occurs at levels over 100 ng/mL in adults who are also ingesting substantial amounts of calcium. Vitamin D toxicity, whether it's from vitamin D3 or vitamin D2, generally occurs after inappropriate use of vitamin D. It’s especially important to avoid excess vitamin D in pregnancy because that can cause calcium levels to rise to the point of causing seizures in the mother and developmental problems in the baby.

Doctor Mike Hansen
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Dosage For Vitamin D, K2, and Calcium

Doses For Vitamin D, K2, and Calcium
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The correct RDA is 8,800 IU per day for vitamin D (according to this article)


Coimbra Protocol for high dose vitamin D



4 ounces of cooked salmon contains approximately 600 IU of vitamin D


Ergocalciferol



Cholecalciferol or Calcifediol in the Management of Vitamin D Deficiency


How to adjust the vitamin D dose for overweight or obese persons?
The Importance of Body Weight for the Dose Response Relationship of Oral Vitamin D Supplementation and Serum 25-Hydroxyvitamin D in Healthy Volunteers

How much K2, vitamin D, and vitamin A to take together?
Are You Taking Vitamin K2 With Your Vitamin D? - Murray Avenue Apothecary - Blog




How much calcium to add?
Vitamin D and calcium supplements: Take them or leave them? - Harvard Health

Are You Taking Too Many Calcium Supplements? – Health Essentials from Cleveland Clinic


Who should receive calcitriol?
calcitriol (vitamin D3) oral/injection | Michigan Medicine
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Vitamin D - Synthesis, Activation, Functions and Deficiency Manifestations || Vitamin D Biochemistry

Vitamin D - Synthesis, Activation, Functions and Deficiency Manifestations - This is the video on vitamin D which is fat soluble vitamin along with examples of theory questions and NEET PG biochemistry MCQs.
00:00 - Introduction
00:40 - Examples of theory questions that can be asked from vitamin D
01:26 - Vitamin D as a hormone
02:04 - Vitamin D structure
02:26 - Synthesis of Vitamin D/Formation of Vitamin D
03:37 - Vitamin D Activation/ Vitamin D Active Forms
05:32 - Vitamin D Sources
06:00 - RDA of Vitamin D
06:13 - Biochemical Functions of Vitamin D
07:37 - Role of Vitamin D in calcium and phosphorus metabolism
09:24 - Causes of vitamin D Deficiency
10:19 - Rickets
10:32 - Characteristic features of Rickets
11:55 - Osteomalacia
12:28 - Renal Rickets (Renal Osteodystrophy)
13:01 - Vitamin D resistant rickets
13:56 - Hypervitaminosis D
14:39 - NEET PG Biochemistry MCQs.

Vitamin D (Cholecalciferol)

Vitamin D is also known as calciferol because of its role in calcium metabolism and antirachitic factor because it prevents rickets.
Other name is SUNSHINE Vitamin

Cholecalciferol is an inactive form of vitamin D.
It needs further metabolism to produce the active form of the vitamin.
1, 25 dihydroxycholecalciferol also known as calcitriol is the active form of vitamin D.

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Vitamin D and Calcium Absorption - Biochemistry Lesson

Lesson on the role and importance of Vitamin D (calcitriol) in calcium absorption and why we actually need vitamin D for proper absorption and utilization of calcium.

Hey everybody! Here is a lesson on the metabolism of vitamin D, the role of vitamin D calcitriol in calcium absorption and why we actually need vitamin D to absorb calcium in our diet!

Topics discussed in this video:

How is calcium absorbed in the body?

What is Vitamin D Calcitriol?

What is the role of Vitamin D Calcitriol in calcium absorption?

Why do we need to eat Vitamin D?

I hope you find this lesson helpful! If you do, please consider liking, subscribing and clicking the notification bell to help support the channel.

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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

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COVID19 and Vit D immunity | Vit D and COVID19 | Coronavirus and Vit D | Basic Science Series

COVID19 and Vitamin D | Immunity and vitamin D | Role of Vitamin D in viral infection | COVID19 and Vit D immunity | Vit D and COVID19 | Coronavirus and Vit D

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The innate immune system consists of physical barriers such as skin mucous membranes, and various cell types like, monocytes and macrophages, cytokines, and the complement. In contrast to the adaptive immune response, the innate response is not specific to any foreign invader and as a result, works quickly to destroy pathogens entered in our body. The key question is that how vitamin D is linked with infection. The simple answer is that the deficiency of vitamin D has been linked to increased risk or severity of viral infections, including HIV. Low levels of vitamin D appear to be a risk factor for other serious infections like tuberculosis. In addition to that, research support that the vitamin D Supplementation may slightly reduce the severity and risk of respiratory tract infections. More specifically, the research studies during COVID-19 pandemic raised concerns that, as vitamin D deficiency is a risk factor in respiratory infection. In addition to that it is also suggested that incidence, severity and outcomes of COVID-19 infection could be related with variances in vitamin D levels. There are several published reports of case series showing direct associations between vitamin D deficiency, COVID-19 infection and severity. The possible benefits by the vitamin D supplementation has been encouraged by various health professionals. howerver there was insufficient evidence at that time to support taking vitamin D supplements specifically to prevent or treat COVID‑19, health professionals recommended all people should continue to follow advice on daily vitamin D supplementation during the COVID‑19 pandemic. All these facts and findings motivates us to know the functions of vitamin D in detail. Before understanding Vitamin D, let’s first understand the vitamin. A vitamin is an organic molecule that is an essential micronutrient. An organism needs a vitamin in small quantities for the proper functioning of its metabolism. Vitamin D is a fat-soluble vitamin and it helps in intestinal absorption of calcium, magnesium, and phosphate, and have multiple other biological effects on our body. In humans, the most important Vitamin D compounds are vitamin D3 (also known as cholecalciferol) and vitamin D2 (ergocalciferol).The major natural source for humans is the synthesis of vit D in the lower layers of skin through a chemical reaction that is dependent on sun exposure. Cholecalciferol and ergocalciferol can be acquired from the diet and from supplements. Only a few foods, such as the flesh of fatty fish, naturally contain significant amounts of vitamin D. In the U.S. and other countries, cow's milk, and plant-derived milk substitutes are fortified with vitamin D. Vitamin D from skin synthesis or from the diet is biologically inactive. Means it has no function in this form. It needs activation. It is activated by two enzyme hydroxylation steps, the first in the liver and the second in the kidneys. As vitamin D can be synthesized in adequate amounts by most mammals if exposed to sufficient sunlight, it is important to know that it is not essential, so technically not a vitamin. Instead, it can be considered a hormone, with activation of the vitamin D pro-hormone resulting in the active form, calcitriol, which then produces effects via a nuclear receptor in multiple locations. Cholecalciferol is converted in the liver to 25-hydroxy cholecalciferol); and ergocalciferol is converted to 25-hydroxy ergocalciferol. These two vitamin D metabolites (called 25-hydroxyvitamin D can be measured in serum to determine a person's vitamin D status. Based on this information the vitamin deficiency can be detected in any patient. 25-hydroxy cholecalciferol is further hydroxylated by the kidneys to form calcitriol (also known as 1,25-dihydroxycholecalciferol), the biologically active form of vitamin D.


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Vitamin D Deficiency (Part 2) | Clinical Features (ex. Osteoporosis), Diagnosis, Treatment

Vitamin D Deficiency (Part 2) | Hyperparathyroidism, Clinical Features (ex. Osteoporosis), Diagnosis, Treatment

This is part 2 in a series on Vitamin D deficiency. In this lesson, we continue with our discussion on Vitamin D deficiency, including hypocalcemia and secondary hyperparathyroidism, clinical features including myalgias & arthralgias, and complications like rickets and osteoporosis. We also discuss methods to diagnose (mild, moderate and severe vitamin D deficiency), and ways to treat it.

This is a very complex topic that definitely requires more discussion! Again, I’m not entirely satisfied with this lesson, so please let me know if you found it helpful!

References (StatPearls, 2020):


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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for EDUCATIONAL PURPOSES ONLY, and information presented here is NOT TO BE USED as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

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Vitamin D3 (Cholecalciferol) - Vitamin D2 (Ergocalciferol) - Calcitriol: Sources, Uses, Dosage ...

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- This is lesson n# 41 in A DRUG IN BRIEF Series. In this video I'm gonna discuss almost all you need to know about Vitamin D3 (Cholecalciferol) - Vitamin D2 (Ergocalciferol) - Calcitriol - Calcidiol: Sources, Uses, Dosage, Side Effects, Mechanism of action, Deficiency, and Contraindications

- In less than 6 minutes you'll learn:

- What is Vitamin D 3?

Vitamin D belongs to the family of fat-soluble vitamins, which include vitamins A, D, E and K. These vitamins are absorbed well with fat and are stored in the liver and fatty tissues.

There are two main forms of vitamin D in the diet:

Vitamin D2 (ergocalciferol): Found in plant foods like mushrooms.
Vitamin D3 (cholecalciferol): The flesh of fatty fish (such as salmon, tuna, and mackerel) and fish liver oils are among the best sources. Small amounts of vitamin D are found in beef liver, cheese, and egg yolks.
Natural sources of vitamin D are limited, especially if you're vegetarian or don't like fish.
Foods such as cow's milk, soy milk, orange juice, cereals, and oatmeal are sometimes fortified with vitamin D.

However, sunlight is the best natural source of vitamin D3. The UV rays from sunlight convert cholesterol in your skin into vitamin D3

- Learn more about Vitamin D mechanism of action, uses, dosage, side effects, and precautions in this video...

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Vitamin D (calciferol): Sources, Synthesis, Metabolism, Functions, RDA, Regulation and Deficiency

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Vitamin D (calciferol): Sources, Synthesis, Metabolism, Functions, RDA, Regulation and Deficiency

Vitamin D (calciferol)

Characteristics
-------------------------
Active form: 1,25-dihydroxyvitamin D (1,25-(OH)2 D3, calcitriol)

Sources:
--------------
Ergocalciferol (vitamin D2): mushrooms, fortified foods (e.g., milk, breakfast cereals, formula), yeast (from ergosterol)
Cholecalciferol (vitamin D3)
Synthesized in the skin (stratum basale) when exposed to UV light
Fortified foods (e.g., milk, breakfast cereals, formula), fatty fish (liver), egg yolks

Vitamin D synthesis
--------------------------------
Liver: cholesterol → 7-dehydrocholesterol (provitamin D3)
Enzyme: cholesterol dehydrogenase
Skin
Storage of 7-dehydrocholesterol
Cleavage of 7-dehydrocholesterol via irradiation with UV light → cholecalciferol (in the stratum basale of the skin)
Liver: hydroxylation of cholecalciferol to 25-hydroxyvitamin D (25-OH D3, calcidiol; activated vitamin D2)
Kidneys: 1α-hydroxylase hydroxylates 25-hydroxyvitamin D → 1,25-dihydroxyvitamin D

Transport to target cells: vitamin D-binding protein (DBP)

Storage: mainly in adipose tissue as 25-hydroxycholecalciferol

Regulation of vitamin D synthesis: via regulation of 1α-hydroxylase activity in proximal convoluted tubule
↓ Calcium, ↓ phosphate, and ↑ PTH → ↑ 1α-hydroxylase activity → ↑ 1,25-dihydroxyvitamin D biosynthesis
↑ Calcium, ↑ phosphate, and ↑ 1,25-dihydroxyvitamin D → ↓ 1α-hydroxylase activity → ↓ 1,25-dihydroxyvitamin D biosynthesis

#vitamind #vitamindbiochemistry #vitamindsources #vitamindbenefits #vitamindsynthesis #vitamindfunctions #vitamindfoods #vitaminddosage #vitaminDrichfoods #vitamindfoods #vitaminDbiology #vitamindmetabolism #vitaminDusmle #vitamindvideo #vitamindlecture #vitamindanimation

Vitamin D VS Vitamin D3

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In this episode, you will learn the difference between Vitamin D and Vitamin D3.

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- Should you take vitamin D or D3?
- Best form of vitamin D for absorption.

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Vitamin D - Activation, Regulation and Function

In this video I have explained the activation of vitamin D in the liver and kidney by hydroxylation process. Regulation of active vitamin D3 by PTH (parathyroid hormone), 24-hydroxylase and active vitamin D itself. Main function of vitamin D is to regulate calcium and phosphate levels in the blood. Other functions of vitamin D have been revealed by recent research like its role in preventing tumor formation, immune mechanism, insulin sensitivity.
Sunlight exposure is the source of vitamin D from our skin.

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Vitamin D3 vs Vitamin D2: Is There A Difference? And Should You Supplement It?

What’s Vitamin D3? Many of us know Vitamin D3 is crucial for bone health and immune system function.

But with rainy days and skin cancer concerns, getting enough Vitamin D3 straight from the source, aka the sun, may be more challenging than you’d think.

There’s Vitamin D2, Vitamin D3, and Vitamin D complex to choose from. Is there a difference between these Vitamin D sources? And how do you know which Vitamin D supplement to choose?

In this video, you’ll find out different types of Vitamin D and which is best for your health goals.

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Vitamin D3 vs Vitamin D2

I've done some research and here are the main differences between Vitamin D3 and Vitamin D2.

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VITAMIN D (CHOLECALCIFEROL) - PHARMACIST REVIEW - #232

In this episode, I discuss a medication known as Vitamin D (cholecalciferol).

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Vitamin D and its Anti-aging Benefits

Vitamin D is really not a vitamin. Vitamins are special nutrients that the body needs but cannot make.
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Vitamin D is a group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, and multiple other biological effects. In humans, the most important compounds in this group are vitamin D3 (also known as cholecalciferol) and vitamin D2 (ergocalciferol). The major natural source of the vitamin is synthesis of cholecalciferol in the lower layers of skin epidermis through a chemical reaction that is dependent on sun exposure (specifically UVB radiation). Cholecalciferol and ergocalciferol can be ingested from the diet and from supplements. Only a few foods, such as the flesh of fatty fish, naturally contain significant amounts of vitamin D. In the U.S. and other countries, cow's milk and plant-derived milk substitutes are fortified with vitamin D, as are many breakfast cereals. Mushrooms exposed to ultraviolet light contribute useful amounts of vitamin D. Dietary recommendations typically assume that all of a person's vitamin D is taken by mouth, as sun exposure in the population is variable and recommendations about the amount of sun exposure that is safe are uncertain in view of the skin cancer risk. Vitamin D from the diet, or from skin synthesis, is biologically inactive. It is activated by two protein enzyme hydroxylation steps, the first in the liver and the second in the kidneys. As vitamin D can be synthesized in adequate amounts by most mammals if exposed to sufficient sunlight, it is not essential, so technically not a vitamin. Instead it can be considered a hormone, with activation of the vitamin D pro-hormone resulting in the active form, calcitriol, which then produces effects via a nuclear receptor in multiple locations. Cholecalciferol is converted in the liver to calcifediol (25-hydroxycholecalciferol); ergocalciferol is converted to 25-hydroxyergocalciferol. These two vitamin D metabolites (called 25-hydroxyvitamin D or 25(OH)D) are measured in serum to determine a person's vitamin D status. Calcifediol is further hydroxylated by the kidneys to form calcitriol (also known as 1,25-dihydroxycholecalciferol), the biologically active form of vitamin D. Calcitriol circulates as a hormone in the blood, having a major role regulating the concentration of calcium and phosphate, and promoting the healthy growth and remodeling of bone. Calcitriol also has other effects, including some on cell growth, neuromuscular and immune functions.
#VitaminD #livelonger #DavidSinclair
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Vitamin D metabolism

This video is an overview of the synthesis and secretion of vitamin D. It starts from its precursor forms and is completed with production of calcitriol. It also reviews how forms of vitamin D maintain normal serum calcium levels.
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A NURSE REVIEWS CHOLECALCIFEROL (VITAMIN D3) FERN-D 1000 IU SOFTGEL CAPSULE | REAL TALK

#Cholecalciferol or #FernD is best to improve immunity. Na try mo na ba ito?

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Difference Between Vitamin D2,D3 & Alfacalcidol(One-Alpha)

Vitamin D

Types of Vitamins, Vitamin D.
Vitamin D2 ( Ergocalciferol)
Vitamin D3 ( Cholecalciferol)
Chemistry, Sources, Activation of Vitamin D.
Why Vit. D is considered a hormone?
Mode of action of calcitriol.
Functions of Vitamin D
Ricketes
Osteomalacia
Renal Ricketes
Hypervitaminosis D
Advisable Review:
( Mechanism of action of group 1 hormones )
( Calcium Metabolism)

Vitamin D and its deficiency associated disease (Ricket & Osteomalacia)

What is VITAMIN D? What does VITAMIN D mean? VITAMIN D meaning, definition & explanation

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What is VITAMIN D? What does VITAMIN D mean? VITAMIN D meaning - VITAMIN D definition - VITAMIN D explanation.

Source: Wikipedia.org article, adapted under license.

Vitamin D refers to a group of fat-soluble secosteroids responsible for enhancing intestinal absorption of calcium, iron, magnesium, phosphate, and zinc. In humans, the most important compounds in this group are vitamin D3 (also known as cholecalciferol) and vitamin D2 (ergocalciferol). Cholecalciferol and ergocalciferol can be ingested from the diet and from supplements. Very few foods contain vitamin D; synthesis of vitamin D (specifically cholecalciferol) in the skin is the major natural source of the vitamin. Dermal synthesis of vitamin D from cholesterol is dependent on sun exposure (specifically UVB radiation).

Vitamin D from the diet or dermal synthesis from sunlight is biologically inactive; activation requires enzymatic conversion (hydroxylation) in the liver and kidney. Evidence indicates the synthesis of vitamin D from sun exposure is regulated by a negative feedback loop that prevents toxicity, but because of uncertainty about the cancer risk from sunlight, no recommendations are issued by the Institute of Medicine (US) for the amount of sun exposure required to meet vitamin D requirements. Accordingly, the Dietary Reference Intake for vitamin D assumes no synthesis occurs and all of a person's vitamin D is from food intake, although that will rarely occur in practice. As vitamin D is synthesized in adequate amounts by most mammals exposed to sunlight, it is not strictly a vitamin, and may be considered a hormone as its synthesis and activity occur in different locations. Vitamin D has a significant role in calcium homeostasis and metabolism. Its discovery was due to effort to find the dietary substance lacking in rickets (the childhood form of osteomalacia).

Beyond its use to prevent osteomalacia or rickets, the evidence for other health effects of vitamin D supplementation in the general population is inconsistent. The effect of vitamin D supplementation on mortality is not clear, with one meta-analysis finding a decrease in mortality in elderly people, and another concluding no clear justification exists for recommending vitamin D.

In the liver, cholecalciferol (vitamin D3) is converted to calcidiol, which is also known as calcifediol (INN), 25-hydroxycholecalciferol (aka 25-hydroxyvitamin D3 — abbreviated 25(OH)D3). Ergocalciferol (vitamin D2) is converted in the liver to 25-hydroxyergocalciferol (aka 25-hydroxyvitamin D2 — abbreviated 25(OH)D2). These two specific vitamin D metabolites are measured in serum to determine a person's vitamin D status. Part of the calcidiol is converted by the kidneys to calcitriol, the biologically active form of vitamin D. Calcitriol circulates as a hormone in the blood, regulating the concentration of calcium and phosphate in the bloodstream and promoting the healthy growth and remodeling of bone. Calcitriol also affects neuromuscular and immune function.

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